2019
Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition
Zhao W, Cao L, Ying H, Zhang W, Li D, Zhu X, Xue W, Wu S, Cao M, Fu C, Qi H, Hao Y, Tang YC, Qin J, Zhong TP, Lin X, Yu L, Li X, Li L, Wu D, Pan W. Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition. Cell Research 2019, 29: 895-910. PMID: 31501519, PMCID: PMC6889172, DOI: 10.1038/s41422-019-0229-5.Peer-Reviewed Original ResearchConceptsVEGFA stimulationEffects of VEGFAMutant zebrafishVascular morphogenesisVascular regressionSynthetase 2Bisphosphate availabilityMetabolic enzymesFOXO1 activationGenetic ablationPostnatal retinaAngiogenic endotheliumPhosphatidylinositolVEGFAPro-angiogenic factorsGrowth factorPathological conditionsVascular endothelial growth factorEndothelial cellsVessel regressionEndothelial growth factorTumor growthTumor modelNovel findingsZebrafish
2017
Nucleoside/nucleotide reverse transcriptase inhibitors attenuate angiogenesis and lymphangiogenesis by impairing receptor tyrosine kinases signalling in endothelial cells
Song L, Ding S, Ge Z, Zhu X, Qiu C, Wang Y, Lai E, Yang W, Sun Y, Chow S, Yu L. Nucleoside/nucleotide reverse transcriptase inhibitors attenuate angiogenesis and lymphangiogenesis by impairing receptor tyrosine kinases signalling in endothelial cells. British Journal Of Pharmacology 2017, 175: 1241-1259. PMID: 28910489, PMCID: PMC5866989, DOI: 10.1111/bph.14036.Peer-Reviewed Original ResearchConceptsReceptor tyrosine kinase internalizationExcessive ROS levelsConfocal immunofluorescence microscopyEndothelial cellsAntiretroviral therapyReceptor tyrosine kinasesMitochondrial DNA copy numberLymphatic endothelial cellsQuantitative real-time PCRMigration of ECsMitochondrial oxidative stressRTK endocytosisDNA copy numberProtein maturationRTK signalsEarly endosomesTube formation assaysTyrosine kinaseCardiovascular diseaseNucleoside/Blood vessel growthReal-time PCRFGFR1 pathwayCopy numberImmunofluorescence microscopy