2023
Endothelial FIS1 DeSUMOylation Protects Against Hypoxic Pulmonary Hypertension
Zhou X, Jiang Y, Wang Y, Fan L, Zhu Y, Chen Y, Wang Y, Zhu Y, Wang H, Pan Z, Li Z, Zhu X, Ren R, Ge Z, Lai D, Lai E, Chen T, Wang K, Liang P, Qin L, Liu C, Qiu C, Simons M, Yu L. Endothelial FIS1 DeSUMOylation Protects Against Hypoxic Pulmonary Hypertension. Circulation Research 2023, 133: 508-531. PMID: 37589160, DOI: 10.1161/circresaha.122.321200.Peer-Reviewed Original ResearchConceptsPulmonary hypertensionHypoxic pulmonary hypertensionPulmonary endothelial functionHuman pulmonary artery endothelial cellsPulmonary artery endothelial cellsPulmonary endotheliumArtery endothelial cellsEndothelial functionEndothelial cellsEndothelial mitochondriaSugen/hypoxia rat modelClinical specimensPulmonary endothelial dysfunctionHypoxia rat modelPulmonary arterial systemHypoxic stressVascular remodeling diseasePrevious clinical researchHuman embryonic stem cell-derived endothelial cellsMitochondrial oxygen consumption rateIntrinsic pathogenesisEndothelial dysfunctionExtracellular acidification rateHypoxic ratsPoor prognosis
2018
Therapeutic effect of human amniotic epithelial cells in murine models of Hashimoto's thyroiditis and Systemic lupus erythematosus
Tan B, Yuan W, Li J, Yang P, Ge Z, Liu J, Qiu C, Zhu X, Qiu C, Lai D, Guo L, Wang L, Yu L. Therapeutic effect of human amniotic epithelial cells in murine models of Hashimoto's thyroiditis and Systemic lupus erythematosus. Cytotherapy 2018, 20: 1247-1258. PMID: 30174233, DOI: 10.1016/j.jcyt.2018.04.001.Peer-Reviewed Original ResearchConceptsExperimental autoimmune thyroiditisSystemic lupus erythematosusHuman amniotic epithelial cellsAnti-nuclear antibodiesSLE miceHashimoto's thyroiditisAutoimmune diseasesMurine modelAmniotic epithelial cellsEAT miceLupus erythematosusTherapeutic strategiesFemale CBA/J miceAnti-thyroid peroxidase antibodiesTh17/Treg cellsCBA/J miceAnti-thyroglobulin antibodiesAnti-dsDNA antibodiesEpithelial cellsNovel therapeutic strategiesNew therapeutic strategiesMRL-FasTreg cellsAutoimmune thyroiditisDifferent time points