FGFR1 SUMOylation coordinates endothelial angiogenic signaling in angiogenesis
Zhu X, Qiu C, Wang Y, Jiang Y, Chen Y, Fan L, Ren R, Wang Y, Chen Y, Feng Y, Zhou X, Zhu Y, Ge Z, Lai D, Qin L, Simons M, Yu L. FGFR1 SUMOylation coordinates endothelial angiogenic signaling in angiogenesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 2022, 119: e2202631119. PMID: 35733256, PMCID: PMC9245619, DOI: 10.1073/pnas.2202631119.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEndothelial CellsFibroblast Growth Factor 2HypoxiaMembrane ProteinsMiceMutationNeovascularization, PhysiologicReceptor, Fibroblast Growth Factor, Type 1Signal TransductionSumoylationVascular Endothelial Growth Factor Receptor-2ConceptsFGF receptor 1VEGFA/VEGFR2 signalingSmall ubiquitin-like modifier (SUMO) modificationSUMOylation-defective mutantReceptor complex formationTyrosine kinase activationVEGFA/VEGFR2Endothelial cellsFGF/FGFRRegulatory featuresEmbryonic developmentTissue homeostasisSUMOylationReversible SUMOylationKinase activationFibroblast growth factorBasic fibroblast growth factorFRS2αVascular developmentVEGFR2 signalingContradictory phenotypesEndothelial sproutingAngiogenic signalingFunctional significanceProangiogenic stimuli