SUMOylation Negatively Regulates Angiogenesis by Targeting Endothelial NOTCH Signaling
Zhu X, Ding S, Qiu C, Shi Y, Song L, Wang Y, Wang Y, Li J, Wang Y, Sun Y, Qin L, Chen J, Simons M, Min W, Yu L. SUMOylation Negatively Regulates Angiogenesis by Targeting Endothelial NOTCH Signaling. Circulation Research 2017, 121: 636-649. PMID: 28760777, PMCID: PMC5581236, DOI: 10.1161/circresaha.117.310696.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsBinding SitesCalcium-Binding ProteinsCells, CulturedCysteine EndopeptidasesEndopeptidasesHuman Umbilical Vein Endothelial CellsHumansIntracellular Signaling Peptides and ProteinsMembrane ProteinsMiceNeovascularization, PhysiologicProtein BindingReceptors, NotchReceptors, Vascular Endothelial Growth FactorSignal TransductionSumoylationConceptsEndothelial NotchPost-translational SUMO modificationCell-cell interaction mechanismRole of SUMOylationNotch signal activationDual-luciferase assayCotranscriptional factorsRegulation of angiogenesisTissue patterningCell fateSUMO conjugationSUMO modificationSignal transductionVEGF receptor signalingSUMOylationImmunoprecipitation analysisRegulatory mechanismsPathway functionDLL4 stimulationBiological eventsReceptor signalingSignal activationCultured endothelial cellsAngiogenic signalingSENP1