Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition
Zhao W, Cao L, Ying H, Zhang W, Li D, Zhu X, Xue W, Wu S, Cao M, Fu C, Qi H, Hao Y, Tang YC, Qin J, Zhong TP, Lin X, Yu L, Li X, Li L, Wu D, Pan W. Endothelial CDS2 deficiency causes VEGFA-mediated vascular regression and tumor inhibition. Cell Research 2019, 29: 895-910. PMID: 31501519, PMCID: PMC6889172, DOI: 10.1038/s41422-019-0229-5.Peer-Reviewed Original ResearchConceptsVEGFA stimulationEffects of VEGFAMutant zebrafishVascular morphogenesisVascular regressionSynthetase 2Bisphosphate availabilityMetabolic enzymesFOXO1 activationGenetic ablationPostnatal retinaAngiogenic endotheliumPhosphatidylinositolVEGFAPro-angiogenic factorsGrowth factorPathological conditionsVascular endothelial growth factorEndothelial cellsVessel regressionEndothelial growth factorTumor growthTumor modelNovel findingsZebrafish