Subretinal Transplantation of Human Amniotic Epithelial Cells in the Treatment of Autoimmune Uveitis in Rats
Li J, Qiu C, Zhang Z, Yuan W, Ge Z, Tan B, Yang P, Liu J, Zhu X, Qiu C, Lai D, Guo L, Yu L. Subretinal Transplantation of Human Amniotic Epithelial Cells in the Treatment of Autoimmune Uveitis in Rats. Cell Transplantation 2018, 27: 1504-1514. PMID: 30168350, PMCID: PMC6180726, DOI: 10.1177/0963689718796196.Peer-Reviewed Original ResearchConceptsExperimental autoimmune uveitisHuman amniotic epithelial cellsT cell subsetsAutoimmune uveitisOcular inflammatory diseaseEAU ratsEnzyme-linked immunosorbent assayAmniotic epithelial cellsSubretinal transplantationInflammatory diseasesSubretinal injectionTherapeutic strategiesDay 0Current immunosuppressive regimensIL-10 levelsEpithelial cellsT regulatory (Treg) cellsImmune cell infiltrationSlit-lamp microscopyMonocyte chemoattractant proteinSerious side effectsInterphotoreceptor retinoid-binding proteinLocal cytokine environmentNovel therapeutic strategiesAlternative therapeutic strategies