Endothelium‐derived lactate is required for pericyte function and blood–brain barrier maintenance
Lee H, Xu Y, Zhu X, Jang C, Choi W, Bae H, Wang W, He L, Jin S, Arany Z, Simons M. Endothelium‐derived lactate is required for pericyte function and blood–brain barrier maintenance. The EMBO Journal 2022, 41: e109890. PMID: 35243676, PMCID: PMC9058541, DOI: 10.15252/embj.2021109890.Peer-Reviewed Original ResearchConceptsGlucose transporter 1Blood-brain barrier breakdownBlood-brain barrier integrityBlood-brain barrier maintenanceMetabolic syndrome patientsLactate productionUseful therapeutic approachOral lactate administrationLactate administrationBarrier breakdownPericyte coverageSyndrome patientsPericyte functionTherapeutic approachesBarrier integrityVascular wallBrain vasculatureMice resultsBarrier maintenanceLactate supplementationEndothelial cellsTransporter 1LactatePericytesCell types