Featured Publications
Anticoagulation Alone vs Anticoagulation Plus Aspirin or DAPT Following Left Atrial Appendage Occlusion
Reinhardt S, Gibson D, Hsu J, Kapadia S, Yeh R, Price M, Piccini J, Nair D, Christen T, Allocco D, Freeman J. Anticoagulation Alone vs Anticoagulation Plus Aspirin or DAPT Following Left Atrial Appendage Occlusion. Journal Of The American College Of Cardiology 2024, 84: 889-900. PMID: 39197978, DOI: 10.1016/j.jacc.2024.05.067.Peer-Reviewed Original ResearchConceptsLeft atrial appendage occlusionRate of adverse eventsAdverse eventsLAA closure deviceAppendage occlusionAntithrombotic strategiesP2Y<sub>12</sub> inhibitorsDays of follow-upMultivariable Cox proportional hazards regressionClosure deviceRisk of adverse eventsCox proportional hazards regressionWatchman FLX deviceDual antiplatelet therapyDevice-related thrombusProportional hazards regressionStroke/transient ischemic attackAntithrombotic regimensFLX deviceAntiplatelet therapyDOACsGroup patientsFollow-upMultivariate analysisHazards regressionNational Trends in the Burden of Atrial Fibrillation During Hospital Admissions for Heart Failure
Reinhardt SW, Chouairi F, Miller PE, Clark KAA, Kay B, Fuery M, Guha A, Freeman JV, Ahmad T, Desai NR, Friedman DJ. National Trends in the Burden of Atrial Fibrillation During Hospital Admissions for Heart Failure. Journal Of The American Heart Association 2021, 10: e019412. PMID: 34013736, PMCID: PMC8483517, DOI: 10.1161/jaha.120.019412.Peer-Reviewed Original ResearchConceptsReduced ejection fractionComorbid atrial fibrillationHeart failureAtrial fibrillationEjection fractionHospital mortalityHF hospitalizationBackground Heart failureConclusion Atrial fibrillationWhite individualsNational Inpatient SampleMedian hospital chargesMore comorbiditiesComorbid hypertensionHF admissionsHF outcomesPatient demographicsDiabetes mellitusHospital admissionHospital chargesInpatient SampleVascular diseaseHospitalizationPatientsMortality
2024
Diastolic dysfunction evaluation by cardiovascular magnetic resonance derived E, a, e’: Comparison to echocardiography
Lamy J, Xiang J, Shah N, Kwan J, Kim Y, Upadhyaya K, Reinhardt S, Meadows J, McNamara R, Baldassarre L, Peters D. Diastolic dysfunction evaluation by cardiovascular magnetic resonance derived E, a, e’: Comparison to echocardiography. Physiological Reports 2024, 12: e70078. PMID: 39604208, PMCID: PMC11602526, DOI: 10.14814/phy2.70078.Peer-Reviewed Original ResearchConceptsCardiovascular magnetic resonanceTransthoracic echocardiographyDiastolic dysfunctionDiastolic functionDiagnostic accuracy of cardiovascular magnetic resonanceEvaluate diastolic dysfunctionCardiovascular magnetic resonance imagingLeft atrial volumeMitral annular velocityHealthy age-matched subjectsComparison to echocardiographyMitral inflow velocityEvaluate diastolic functionAge-matched subjectsPresence of DDAtrial volumeDD gradeFirst-lineAnnular velocityDiagnostic accuracyImaging modalitiesMagnetic resonanceEchocardiographyALLTransthoracicFactors associated with reporting left ventricular ejection fraction with 3D echocardiography in real‐world practice
Faridi K, Zhu Z, Shah N, Crandall I, McNamara R, Flueckiger P, Bachand K, Lombo B, Hur D, Agarwal V, Reinhardt S, Velazquez E, Sugeng L. Factors associated with reporting left ventricular ejection fraction with 3D echocardiography in real‐world practice. Echocardiography 2024, 41: e15774. PMID: 38329886, DOI: 10.1111/echo.15774.Peer-Reviewed Original ResearchConceptsTransthoracic echocardiogramVentricular ejection fractionOutpatient transthoracic echocardiogramsReal-world practiceEjection fractionLeft ventricular ejection fractionAssess left ventricular ejection fractionInpatient transthoracic echocardiogramsMultivariate logistic regressionLVEFHospitalized patientsMedical CenterSonographersClinical settingLogistic regressionUltrasound machineChemotherapyContrast enhancement agentsPortable studiesNegative association
2021
Trends and Outcomes of Cardiac Transplantation in the Lowest Urgency Candidates
Fuery MA, Chouairi F, Natov P, Bhinder J, Rose Chiravuri M, Wilson L, Clark KA, Reinhardt SW, Mullan C, Miller PE, Davis RP, Rogers JG, Patel CB, Sen S, Geirsson A, Anwer M, Desai N, Ahmad T. Trends and Outcomes of Cardiac Transplantation in the Lowest Urgency Candidates. Journal Of The American Heart Association 2021, 10: e023662. PMID: 34743559, PMCID: PMC9075266, DOI: 10.1161/jaha.121.023662.Peer-Reviewed Original ResearchConceptsLow-urgency patientsHigh-urgency patientsUrgency patientsCardiac transplantationAllocation system changeLonger waitlist timesOrgan Sharing databaseTime of transplantationCardiac transplantation candidatesNew allocation systemBaseline recipientPosttransplantation outcomesPosttransplantation survivalAdditional comorbiditiesClinical characteristicsConclusions PatientsHepatitis CIschemic timeTransplantation candidatesSharing databaseWaitlist timeWaitlist survivalUnited NetworkRetrospective analysisPatientsCannabis use disorder among atrial fibrillation admissions, 2008–2018
Chouairi F, Miller PE, Guha A, Clarke J, Reinhardt SW, Ahmad T, Freeman JV, Desai NR, Friedman DJ. Cannabis use disorder among atrial fibrillation admissions, 2008–2018. Pacing And Clinical Electrophysiology 2021, 44: 1934-1938. PMID: 34506639, DOI: 10.1111/pace.14356.Peer-Reviewed Original ResearchConceptsAtrial fibrillation hospitalizationsAF hospitalizationsImpact of CUDNational Inpatient SampleProportion of admissionsDiseases diagnosis codesPrevalence of cannabisHistory of CUDHospital dischargeYounger patientsHigher proportionUnderserved patientsBlack raceDiagnosis codesInpatient SampleInternational ClassificationHospitalizationLegality of cannabisCannabis usePatientsAdmissionCodiagnosisLittle dataCUDCannabisPersonalizing the decision of dabigatran versus warfarin in atrial fibrillation: A secondary analysis of the Randomized Evaluation of Long-term anticoagulation therapY (RE-LY) trial
Reinhardt SW, Desai NR, Tang Y, Jones PG, Ader J, Spertus JA. Personalizing the decision of dabigatran versus warfarin in atrial fibrillation: A secondary analysis of the Randomized Evaluation of Long-term anticoagulation therapY (RE-LY) trial. PLOS ONE 2021, 16: e0256338. PMID: 34411158, PMCID: PMC8376053, DOI: 10.1371/journal.pone.0256338.Peer-Reviewed Original ResearchConceptsAbsolute risk reductionPrior stroke/TIAStroke/TIASystemic embolismAtrial fibrillationMajor bleedingRE-LYOlder patientsLong-Term Anticoagulation Therapy (RE-LY) trialStroke/systemic embolismGood renal functionHigh-risk patientsHistory of diabetesRE-LY trialPatient-level dataShared decision makingMedian followRenal functionHeart failureHeavier patientsMultivariable modelDabigatranIndividual patientsTreatment groupsIndividualized estimatesComparison of Transcatheter and Open Mitral Valve Repair Among Patients With Mitral Regurgitation
Kay B, Chouairi F, Clark KAA, Reinhardt SW, Fuery M, Guha A, Ahmad T, Kaple RK, Desai NR. Comparison of Transcatheter and Open Mitral Valve Repair Among Patients With Mitral Regurgitation. Mayo Clinic Proceedings 2021, 96: 1522-1529. PMID: 34088415, DOI: 10.1016/j.mayocp.2021.01.029.Peer-Reviewed Original ResearchConceptsMitral valve repairMitral regurgitationValve repairInternational ClassificationPatient underwent mitral valve repairOpen mitral valve repairUnderwent mitral valve repairTranscatheter mitral valve repairStudy periodComparison of transcatheterProhibitive surgical riskTenth Revision codesTotal hospital chargesDegenerative mitral regurgitationNational Inpatient SampleLength of stayTranscatheter mitral valve repair deviceDischarge homeHospital mortalityDischarge dispositionPatient comorbiditiesSurgical riskHospital chargesMedian lengthNinth Revision
2020
Sex Differences in Patients Receiving Left Ventricular Assist Devices for End-Stage Heart Failure
Gruen J, Caraballo C, Miller PE, McCullough M, Mezzacappa C, Ravindra N, Mullan CW, Reinhardt SW, Mori M, Velazquez E, Geirsson A, Ahmad T, Desai NR. Sex Differences in Patients Receiving Left Ventricular Assist Devices for End-Stage Heart Failure. JACC Heart Failure 2020, 8: 770-779. PMID: 32653446, DOI: 10.1016/j.jchf.2020.04.015.Peer-Reviewed Original ResearchConceptsAdverse eventsVentricular assist deviceClinical outcomesPotential underuseHigh riskAssist deviceEnd-stage heartWomen 65 yearsRisk of deathContinuous-flow LVADYears of ageAdvanced treatment optionsSex differencesHeart transplantationMultivariable adjustmentHeart failureHeart transplantSimilar incidenceTreatment optionsSimilar riskSurvival analysisLVADPatientsDevice malfunctionWomenNeurohormonal Blockade and Clinical Outcomes in Patients With Heart Failure Supported by Left Ventricular Assist Devices
McCullough M, Caraballo C, Ravindra NG, Miller PE, Mezzacappa C, Levin A, Gruen J, Rodwin B, Reinhardt S, van Dijk D, Ali A, Ahmad T, Desai NR. Neurohormonal Blockade and Clinical Outcomes in Patients With Heart Failure Supported by Left Ventricular Assist Devices. JAMA Cardiology 2020, 5: 175-182. PMID: 31738366, PMCID: PMC6865330, DOI: 10.1001/jamacardio.2019.4965.Peer-Reviewed Original ResearchConceptsKansas City Cardiomyopathy Questionnaire scoreNeurohormonal blockadeAngiotensin receptor blockersVentricular assist deviceQuality of lifeMineralocorticoid antagonistsReceptor blockersHeart failureWalk testQuestionnaire scoresΒ-blockersEnzyme inhibitorsAssist deviceGuideline-directed medical therapyAngiotensin-converting enzyme inhibitorMechanically Assisted Circulatory SupportHeart failure regimenLeft ventricular assist deviceAdvanced heart failureRetrospective cohort analysisContinuous-flow LVADBetter survival rateOutcomes of interestInteragency RegistryTriple therapy
2019
Clinical Outcomes After Left Ventricular Assist Device Implantation in Older Adults An INTERMACS Analysis
Caraballo C, DeFilippis EM, Nakagawa S, Ravindra NG, Miller PE, Mezzacappa C, McCullough M, Gruen J, Levin A, Reinhardt S, Mullan C, Ali A, Maurer MS, Desai NR, Ahmad T, Topkara VK. Clinical Outcomes After Left Ventricular Assist Device Implantation in Older Adults An INTERMACS Analysis. JACC Heart Failure 2019, 7: 1069-1078. PMID: 31779930, DOI: 10.1016/j.jchf.2019.10.004.Peer-Reviewed Original ResearchConceptsYears of ageVentricular assist device implantationAssist device implantationOlder adultsElderly patientsLVAD implantationDevice implantationMultivariate Cox proportional hazards regression modelCox proportional hazards regression modelKaplan-Meier survival estimatesMechanically Assisted Circulatory SupportProportional hazards regression modelsMechanical circulatory support technologyPost-LVAD outcomesHeart failure populationLog-rank testingSerum albumin levelPredictors of survivalPost-LVAD implantationHazards regression modelsPredictors of outcomeAge-specific outcomesAntithrombotic regimenDurable MCSINTERMACS AnalysisClinical Implications of Respiratory Failure in Patients Receiving Durable Left Ventricular Assist Devices for End-Stage Heart Failure
Miller PE, Caraballo C, Ravindra NG, Mezzacappa C, McCullough M, Gruen J, Levin A, Reinhardt S, Ali A, Desai NR, Ahmad T. Clinical Implications of Respiratory Failure in Patients Receiving Durable Left Ventricular Assist Devices for End-Stage Heart Failure. Circulation Heart Failure 2019, 12: e006369. PMID: 31707800, DOI: 10.1161/circheartfailure.119.006369.Peer-Reviewed Original ResearchMeSH KeywordsAgedDisease ProgressionFemaleFrailtyHealth StatusHeart FailureHeart-Assist DevicesHumansIntubation, IntratrachealLungMaleMiddle AgedProsthesis DesignQuality of LifeRecovery of FunctionRegistriesRespiratory InsufficiencyRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeVentricular Function, LeftConceptsMechanically Assisted Circulatory Support profile 1 patientsVentricular assist device implantationProfile 1 patientsAssist device implantationRespiratory failureInteragency RegistryLVAD implantationCirculatory supportDevice implantationMechanically Assisted Circulatory Support profile 1Right ventricular assist device implantationLeft ventricular assist device implantationAdvanced heart failure patientsEnd-stage heart failureMechanically Assisted Circulatory SupportAdvanced heart failure populationHeart failure populationHeart failure patientsLandmark clinical trialsMechanical circulatory supportContinuous-flow LVADVentricular assist devicePostimplant complicationsFailure patientsLVAD placement
2018
Late Presentation and Missed Opportunities for HIV Diagnosis in Guatemala
Meléndez J, Reinhardt SW, O’Halloran J, Spec A, Alonzo Cordon A, Powderly WG, Mejia Villatoro C. Late Presentation and Missed Opportunities for HIV Diagnosis in Guatemala. AIDS And Behavior 2018, 23: 920-928. PMID: 30426264, PMCID: PMC7397713, DOI: 10.1007/s10461-018-2331-y.Peer-Reviewed Original ResearchConceptsLate presentersHIV diagnosisLarge tertiary referral centerEarly HIV diagnosisRetrospective cohort studyProportion of patientsTertiary referral centerTraditional healthcare settingsMissed opportunityCohort studyReferral centerLate presentationOutpatient careHealthcare settingsPatientsDiagnosisYear rateHigh rateCareRural dwellersMorbidityHIVMortalityProportionAIDSEffect of Race on Outcomes Following Early Coronary Computed Tomographic Angiography or Standard Emergency Department Evaluation for Acute Chest Pain.
Reinhardt SW, Babatunde A, Novak E, Brown DL. Effect of Race on Outcomes Following Early Coronary Computed Tomographic Angiography or Standard Emergency Department Evaluation for Acute Chest Pain. Ethnicity & Disease 2018, 28: 517-524. PMID: 30405295, PMCID: PMC6200301, DOI: 10.18865/ed.28.4.517.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeEmergency department evaluationChest painMedian LOSDepartment evaluationCaucasian patientsDownstream testingMyocardial ischemia/infarctionRadiation exposureDirect ED dischargeStandard ED evaluationAcute chest painRecurrent chest painLength of stayCumulative radiation exposureIschemia/infarctionGreater radiation exposureStandard evaluationEarly CCTAIndex visitCoronary syndromeED dischargeED evaluationED visitsHospital admissionNoninvasive Cardiac Testing vs Clinical Evaluation Alone in Acute Chest Pain: A Secondary Analysis of the ROMICAT-II Randomized Clinical Trial
Reinhardt SW, Lin CJ, Novak E, Brown DL. Noninvasive Cardiac Testing vs Clinical Evaluation Alone in Acute Chest Pain: A Secondary Analysis of the ROMICAT-II Randomized Clinical Trial. JAMA Internal Medicine 2018, 178: 212-219. PMID: 29138794, PMCID: PMC5838790, DOI: 10.1001/jamainternmed.2017.7360.Peer-Reviewed Original ResearchConceptsMajor adverse cardiac eventsLength of stayAcute chest painAcute coronary syndromePercutaneous coronary interventionChest painClinical evaluationCumulative radiation exposureNoninvasive testingEmergency departmentIndex visitED visitsRadiation exposureDownstream testingCoronary artery bypass surgeryRate of PCILonger LOSShorter LOSMyocardial ischemia/infarctionDirect ED dischargeAdverse cardiac eventsRecurrent chest painSafety end pointArtery bypass surgeryNoninvasive cardiac testing
2013
Bouveret's Syndrome Complicated by Classic Gallstone Ileus: Progression of Disease or Iatrogenic?
Reinhardt SW, Jin LX, Pitt SC, Earl TM, Chapman WC, Doyle MB. Bouveret's Syndrome Complicated by Classic Gallstone Ileus: Progression of Disease or Iatrogenic? Journal Of Gastrointestinal Surgery 2013, 17: 2020-2024. PMID: 24018589, DOI: 10.1007/s11605-013-2301-7.Peer-Reviewed Original ResearchConceptsDistal gallstone ileusBouveret's syndromeGallstone ileusSmall bowel obstructionProgression of diseaseShock wave lithotripsyEpigastric painAbdominal painBowel obstructionGastroduodenal obstructionRare complicationDuodenal diverticulumSecond patientFirst patientOptimal treatmentRepeat imagingIatrogenic etiologyTomography scanIleusEndoscopic techniquesStone removalWave lithotripsySyndromePatientsNatural history