2003
Neural correlates of declarative memory for emotionally valenced words in women with posttraumatic stress disorder related to early childhood sexual abuse
Bremner JD, Vythilingam M, Vermetten E, Southwick SM, McGlashan T, Staib LH, Soufer R, Charney DS. Neural correlates of declarative memory for emotionally valenced words in women with posttraumatic stress disorder related to early childhood sexual abuse. Biological Psychiatry 2003, 53: 879-889. PMID: 12742675, DOI: 10.1016/s0006-3223(02)01891-7.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAbuse-related posttraumatic stress disorderMedial prefrontal cortexBrain areasPrefrontal cortexEarly childhood sexual abuseBlood flowChildhood abuse-related posttraumatic stress disorderSexual abuse-related posttraumatic stress disorderStress disorderChildhood sexual abuseCerebral blood flowPositron emission tomographic measurementsSpecific brain areasInferior temporal gyrusInferior parietal cortexMiddle frontal gyrusNeural correlatesTrauma-specific stimuliDeclarative memoryMotor cortexControl subjectsFrontal cortexSymptom provocationAnimal studies
1997
Positron Emission Tomography Measurement of Cerebral Metabolic Correlates of Yohimbine Administration in Combat-Related Posttraumatic Stress Disorder
Bremner JD, Innis RB, Ng CK, Staib LH, Salomon RM, Bronen RA, Duncan J, Southwick SM, Krystal JH, Rich D, Zubal G, Dey H, Soufer R, Charney DS. Positron Emission Tomography Measurement of Cerebral Metabolic Correlates of Yohimbine Administration in Combat-Related Posttraumatic Stress Disorder. JAMA Psychiatry 1997, 54: 246-254. PMID: 9075465, DOI: 10.1001/archpsyc.1997.01830150070011.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAdministration of yohimbineNorepinephrine releaseHealthy subjectsHealthy age-matched control subjectsAge-matched control subjectsStress disorderDouble-blind fashionPositron emission tomography (PET) measurementsBrain metabolic responsesCerebral metabolic correlatesBrain norepinephrine releaseSymptoms of anxietyPositron emission tomographyBrain metabolismControl subjectsYohimbine administrationPreclinical studiesMetabolic correlatesCaudate nucleusPatientsYohimbineVietnam combat veteransEmission tomographyOrbitofrontal cortex