Ricardo Avendaño, MD
Clinical FellowAbout
Research
Publications
2024
MULTIMODALITY IMAGING GUIDED INTRAMYOCARDIAL DELIVERY OF IMAGEABLE HYDROGEL POST MYOCARDIAL INFARCTION IMPROVES STRAIN ASSOCIATED WITH INTEGRIN ACTIVATION
Melvinsdottir I, Midgett D, Lee S, Chen K, Avendano R, Ahn S, Thorn S, Uman S, Sinusas A. MULTIMODALITY IMAGING GUIDED INTRAMYOCARDIAL DELIVERY OF IMAGEABLE HYDROGEL POST MYOCARDIAL INFARCTION IMPROVES STRAIN ASSOCIATED WITH INTEGRIN ACTIVATION. Journal Of The American College Of Cardiology 2024, 83: 1399. DOI: 10.1016/s0735-1097(24)03389-8.Peer-Reviewed Original Research
2023
Improvement in cardiac function and regional LV strain following intramyocardial injection of a theranostic hydrogel early postmyocardial infarction in a porcine model
Avendaño R, Midgett D, Melvinsdottir I, Thorn S, Uman S, Pickell Z, Lee S, Liu Z, Mamarian M, Duncan J, Spinale F, Burdick J, Sinusas A. Improvement in cardiac function and regional LV strain following intramyocardial injection of a theranostic hydrogel early postmyocardial infarction in a porcine model. Journal Of Applied Physiology 2023, 135: 405-420. PMID: 37318987, PMCID: PMC10538987, DOI: 10.1152/japplphysiol.00342.2022.Peer-Reviewed Original ResearchConceptsMyocardial infarctionIntramyocardial deliveryLV hemodynamicsControl groupFunctional indexEarly post-myocardial infarctionSystolic functional indicesMyocardial performance indexAnterolateral myocardial infarctionLeft anterior descendingPressure-volume loop areaLeft ventricular remodelingGlobal LV functionLV functional changesPost-myocardial infarctionSupply/demand ratioRegional LV strainHydrogel groupTei indexEjection fractionHeart failureAnterior descendingCircumflex arteryLV functionAortic pressure
2022
Quantification of intramyocardial blood volume using 99mTc-RBC SPECT/CT: a pilot human study
Yousefi H, Shi L, Soufer A, Tsatkin V, Bruni W, Avendano R, Greco K, McMahon D, Thorn S, Miller E, Sinusas A, Liu C. Quantification of intramyocardial blood volume using 99mTc-RBC SPECT/CT: a pilot human study. Journal Of Nuclear Cardiology 2022, 30: 292-297. PMID: 36319815, DOI: 10.1007/s12350-022-03123-0.Peer-Reviewed Original ResearchAround and Around…A Wide Complex Tachycardia
Avendaño R, Lavi N, Rosenfeld LE. Around and Around…A Wide Complex Tachycardia. Circulation 2022, 145: 1867-1869. PMID: 35728056, DOI: 10.1161/circulationaha.122.060648.Peer-Reviewed Original ResearchCineCT platform for in vivo and ex vivo measurement of 3D high resolution Lagrangian strains in the left ventricle following myocardial infarction and intramyocardial delivery of theranostic hydrogel
Midgett D, Thorn S, Ahn S, Uman S, Avendano R, Melvinsdottir I, Lysyy T, Kim J, Duncan J, Humphrey J, Papademetris X, Burdick J, Sinusas A. CineCT platform for in vivo and ex vivo measurement of 3D high resolution Lagrangian strains in the left ventricle following myocardial infarction and intramyocardial delivery of theranostic hydrogel. Journal Of Molecular And Cellular Cardiology 2022, 166: 74-90. PMID: 35227737, PMCID: PMC9035115, DOI: 10.1016/j.yjmcc.2022.02.004.Peer-Reviewed Original Research
2021
Novel SPECT and PET Tracers and Myocardial Imaging
Melvinsdottir I, Avendaño R, Sinusas A. Novel SPECT and PET Tracers and Myocardial Imaging. 2021, 189-228. DOI: 10.1007/978-3-030-83167-7_11.Peer-Reviewed Original ResearchPositron emission tomographyPET imagingMultimodality cardiovascular imagingSingle photon emissionRisk stratificationPathophysiological changesCardiac functionMyocardial remodelingMyocardial diseaseAutonomic regulationMyocardial imagingEmission tomographyHigh-resolution anatomicalMyocardial flowCardiovascular imagingPET tracersNovel SPECTMolecular changesSPECTPhoton emissionHybrid imaging technologyCell deathVivo detectionMolecular imagingImagingEffect of Hydroxychloroquine on QTc in Patients Diagnosed with COVID-19: A Systematic Review and Meta-Analysis
Arfaras-Melainis A, Tzoumas A, Kokkinidis D, Guerrero M, Varrias D, Xu X, Cerna L, Avendano R, Kemal C, Palaiodimos L, Faillace R. Effect of Hydroxychloroquine on QTc in Patients Diagnosed with COVID-19: A Systematic Review and Meta-Analysis. Journal Of Cardiovascular Development And Disease 2021, 8: 55. PMID: 34068104, PMCID: PMC8152730, DOI: 10.3390/jcdd8050055.Peer-Reviewed Original ResearchSARS-CoV-2 infectionUse of hydroxychloroquineAddition of azithromycinEffect of hydroxychloroquineSystematic reviewQTc prolongationQTc intervalManagement of patientsNumber of patientsCOVID-19Random-effects modelMedRxiv databasesCombination therapyConcomitant useInclusion criteriaHydroxychloroquinePatientsI-squarePrespecified endpointsAzithromycinQTcMeta-AnalysisInfectionSignificant increaseΔQTc
2020
Anger recall mental stress decreases 123I-metaiodobenzylguanidine (123I-MIBG) uptake and increases heterogeneity of cardiac sympathetic activity in the myocardium in patients with ischemic cardiomyopathy
Avendaño R, Hashemi-Zonouz T, Sandoval V, Liu C, Burg M, Sinusas AJ, Lampert R, Liu YH. Anger recall mental stress decreases 123I-metaiodobenzylguanidine (123I-MIBG) uptake and increases heterogeneity of cardiac sympathetic activity in the myocardium in patients with ischemic cardiomyopathy. Journal Of Nuclear Cardiology 2020, 29: 798-809. PMID: 33034036, DOI: 10.1007/s12350-020-02372-1.Peer-Reviewed Original ResearchConceptsSympathetic activityIschemic cardiomyopathyVentricular arrhythmiasICM patientsMental stressAge-matched healthy male controlsCardiac sympathetic activityHealthy control subjectsMyocardial sympathetic activityHealthy male controlsMental stress taskSPECT/CTMediastinal ratioControl subjectsHemodynamic responseAnger recallMyocardial perfusionNormal subjectsMale controlsPatientsPerfusionPsychological stressorsArrhythmiasStress taskDual-isotope imagingApplication Of Cine CT Imaging For Evaluation Of Biomechanics Of The Left Ventricle Post Myocardial Infarction And Following Intramyocardial Delivery Of Imageable Hydrogel
Midgett D, Sinusas A, Melvinsdottir I, Avendano R, Lee S. Application Of Cine CT Imaging For Evaluation Of Biomechanics Of The Left Ventricle Post Myocardial Infarction And Following Intramyocardial Delivery Of Imageable Hydrogel. Journal Of Cardiovascular Computed Tomography 2020, 14: s28-s29. DOI: 10.1016/j.jcct.2020.06.035.Peer-Reviewed Original ResearchChapter 1 Embryology, Anatomy, and Physiology Anatomical Variations, Lipomatous Hypertrophy, Atrial Septal Aneurysm, Eustachian Valve, Chiari Network, Combination With Other Atrial Septal Defects
Kokkinidis D, Rios S, Avendano R, Zaidi A, Faillace R. Chapter 1 Embryology, Anatomy, and Physiology Anatomical Variations, Lipomatous Hypertrophy, Atrial Septal Aneurysm, Eustachian Valve, Chiari Network, Combination With Other Atrial Septal Defects. 2020, 3-12. DOI: 10.1016/b978-0-12-816966-7.00001-4.Peer-Reviewed Original ResearchPatent foramen ovaleAtrial septal aneurysmSeptal aneurysmPercutaneous closureEustachian valveInteratrial septumChiari networkSerious clinical syndromeAtrial septal defectCongenital cardiac malformationsParadoxical systemic embolismSystemic embolismIschemic strokeProfound hypoxemiaLipomatous hypertrophyForamen ovaleAnatomic anomaliesClinical syndromeInteratrial communicationMyocardial infarctionSeptal defectRisk factorsClinical impactMigraine headacheCardiac malformations