Stress-Induced Autonomic Dysfunction is Associated With Mental Stress–Induced Myocardial Ischemia in Patients With Coronary Artery Disease
Osei J, Vaccarino V, Wang M, Shah A, Lampert R, Li L, Ko Y, Pearce B, Kutner M, Garcia E, Piccinelli M, Raggi P, Bremner J, Quyyumi A, Sun Y, Ahmed H, Haddad G, Daaboul O, Roberts T, Stefanos L, Correia L, Shah A. Stress-Induced Autonomic Dysfunction is Associated With Mental Stress–Induced Myocardial Ischemia in Patients With Coronary Artery Disease. Circulation Cardiovascular Imaging 2024, 17: e016596. PMID: 38868952, PMCID: PMC11187646, DOI: 10.1161/circimaging.124.016596.Peer-Reviewed Original ResearchConceptsMental stress-induced myocardial ischemiaLow heart rate variabilityAssociated with MSIMICoronary artery diseaseAssociated with higher oddsStable coronary artery diseaseStress-induced myocardial ischemiaAutonomic dysfunctionLow-frequency heart rate variabilityArtery diseaseHeart rate variabilityHigher oddsHigher heart rate variabilityResponse to stressIndicator of autonomic dysfunctionMyocardial ischemiaSpeech stressorAssociated with adverse cardiovascular outcomesMultivariate logistic regression modelAssociation of autonomic dysfunctionAdverse cardiovascular outcomesLogistic regression modelsBlack participantsHolter monitoringClinical factorsHeart Rate Variability, Deceleration Capacity of Heart Rate, and Death: A Veteran Twins Study
Huang M, Shah A, Lampert R, Bliwise D, Johnson D, Clifford G, Sloan R, Goldberg J, Ko Y, Da Poian G, Perez‐Alday E, Almuwaqqat Z, Shah A, Garcia M, Young A, Moazzami K, Bremner J, Vaccarino V. Heart Rate Variability, Deceleration Capacity of Heart Rate, and Death: A Veteran Twins Study. Journal Of The American Heart Association 2024, 13: e032740. PMID: 38533972, PMCID: PMC11179789, DOI: 10.1161/jaha.123.032740.Peer-Reviewed Original ResearchConceptsLow-frequency heart rate variabilityHazard of deathAssociated with reduced mortality riskMortality riskMultivariable Cox frailty modelsHeart rate variabilityAssociated with decreased hazard of deathNational Death IndexDeceleration capacityAssociated with lower hazardWithin-pair analysesTwin studiesCox frailty modelsHazard ratio of deathRatio of deathDeceleration capacity of heart rateAssociated with decreased hazardDeath IndexHeart rateAll-cause deathHazard ratioFrequency domain heart rate variabilityStrong associations