Transfection with keratinocyte growth factor 1 cDNA with electroporation improves wound healing in an aged mouse model
Marti G, Makary M, Ferguson M, Wang J, Dieb R, Marti A, Lin M, Bonde P, Duncan M, Harmon J. Transfection with keratinocyte growth factor 1 cDNA with electroporation improves wound healing in an aged mouse model. Journal Of Surgical Research 2004, 121: 320-321. DOI: 10.1016/j.jss.2004.07.175.Peer-Reviewed Original ResearchAged animal modelsAnimal modelsWound sizeWound closureAged mouse modelMice 6 weeksKGF-1Young animalsAverage wound sizeT-testStudent's t-testCutaneous wound closureFull-thickness woundsElderly miceAged miceBALBc miceMouse modelAge groupsDay 12DNA expression vectorsGrowth factorMiceWound areaProliferative capacityUntreated woundsKGF-1 plasmid delivered with electroporation accelerates wound closure in diabetic mice
Marti G, Lin M, Qaiser R, Dieb R, Wang J, Parth S, Bonde P, Duncan M, Harmon J. KGF-1 plasmid delivered with electroporation accelerates wound closure in diabetic mice. Journal Of The American College Of Surgeons 2004, 199: 59. DOI: 10.1016/j.jamcollsurg.2004.05.121.Peer-Reviewed Original ResearchDiabetic miceGrowth factorKGF-1Diabetic mouse modelWound healing deficitsUnmet medical challengeKeratinocyte growth factorFull-thickness woundsImportant growth factorDiabetic individualsHistological assessmentHealing deficitsMouse modelEP groupClosure of woundsGrading scaleMedical challengeDNA expression vectorsThickness woundsWound areaDiminished levelsWoundsUntreated woundsMiceCMV promoter