2019
Novel Matrix Metalloproteinase 12 Selective Radiotracers for Vascular Molecular Imaging
Toczek J, Bordenave T, Gona K, Kim HY, Beau F, Georgiadis D, Correia I, Ye Y, Razavian M, Jung J, Lequin O, Dive V, Sadeghi MM, Devel L. Novel Matrix Metalloproteinase 12 Selective Radiotracers for Vascular Molecular Imaging. Journal Of Medicinal Chemistry 2019, 62: 9743-9752. PMID: 31603669, PMCID: PMC7054845, DOI: 10.1021/acs.jmedchem.9b01186.Peer-Reviewed Original ResearchConceptsAbdominal aortic aneurysmVascular molecular imagingMurine abdominal aortic aneurysmsMMP-12 gene expressionMatrix metalloproteinase-12Aortic aneurysmInflammatory diseasesAdjacent aortaH postinjectionMMP-12Blood clearanceMetalloproteinase-12Selective radiotracerFurther evaluationMMP-12 inhibitorsMouse bloodHigh uptakeAortaDiseaseMolecular imagingHuman metalloproteasesRadiotracer
2012
Molecular Imaging of Vascular Inflammation, Atherosclerosis, and Thrombosis
Jane-Wit D, Sadeghi M. Molecular Imaging of Vascular Inflammation, Atherosclerosis, and Thrombosis. Molecular And Translational Medicine 2012, 129-166. DOI: 10.1007/978-1-61779-906-8_5.Peer-Reviewed Original ResearchVascular molecular imagingVascular diseasePathogenesis of atherogenesisMolecular imagingEvaluation of atherosclerosisSpecific patient populationsMolecular imaging approachesVascular biology researchExtracellular matrix remodelingRisk stratificationVascular inflammationPatient populationClinical studiesEarly diagnosisNumber of subjectsClinical practiceCardiovascular medicineNew drugsIntact subjectsMatrix remodelingLongitudinal studyAtherosclerosisDetection of pathwaysInflammationDrug development