2012
Molecular Imaging of Vascular Inflammation, Atherosclerosis, and Thrombosis
Jane-Wit D, Sadeghi M. Molecular Imaging of Vascular Inflammation, Atherosclerosis, and Thrombosis. Molecular And Translational Medicine 2012, 129-166. DOI: 10.1007/978-1-61779-906-8_5.Peer-Reviewed Original ResearchVascular molecular imagingVascular diseasePathogenesis of atherogenesisMolecular imagingEvaluation of atherosclerosisSpecific patient populationsMolecular imaging approachesVascular biology researchExtracellular matrix remodelingRisk stratificationVascular inflammationPatient populationClinical studiesEarly diagnosisNumber of subjectsClinical practiceCardiovascular medicineNew drugsIntact subjectsMatrix remodelingLongitudinal studyAtherosclerosisDetection of pathwaysInflammationDrug development
2011
Integrin-Targeted Imaging of Inflammation in Vascular Remodeling
Razavian M, Marfatia R, Mongue-Din H, Tavakoli S, Sinusas AJ, Zhang J, Nie L, Sadeghi MM. Integrin-Targeted Imaging of Inflammation in Vascular Remodeling. Arteriosclerosis Thrombosis And Vascular Biology 2011, 31: 2820-2826. PMID: 21940943, PMCID: PMC3228522, DOI: 10.1161/atvbaha.111.231654.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApolipoproteins ECalcium ChlorideCarotid Artery DiseasesCells, CulturedDisease Models, AnimalFemaleFluorescent DyesHumansInflammationIntegrin alphaVIntegrin alphaVbeta3Leukocytes, MononuclearMacrophagesMiceMice, KnockoutPeptides, CyclicRNA, MessengerTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedConceptsVessel wall inflammationCarotid arteryWall inflammationTomography/CT imagingConsiderable macrophage infiltrationLeft carotid arteryMacrophage marker expressionReal-time polymerase chain reactionAdventitial exposureImaging of inflammationAntiinflammatory treatmentVascular eventsMacrophage infiltrationLeft carotidPolymerase chain reactionVascular diseaseContralateral arteryVascular remodelingHigh riskMurine carotid arteriesInflammationArteryFlow cytometryHuman monocytesMRNA expression
2009
Imaging of vascular biology in the heart
Tavakoli S, Sadeghi M. Imaging of vascular biology in the heart. Current Cardiovascular Imaging Reports 2009, 2: 40-49. DOI: 10.1007/s12410-009-0006-9.Peer-Reviewed Original Research
2006
The pathobiology of the vessel wall: Implications for imaging
Sadeghi MM. The pathobiology of the vessel wall: Implications for imaging. Journal Of Nuclear Cardiology 2006, 13: 402-414. PMID: 16750785, DOI: 10.1016/j.nuclcard.2006.03.012.Peer-Reviewed Original ResearchConceptsVascular diseaseVessel wallDiagnostic approachMagnetic resonance imaging angiographyDiseased coronary segmentsMolecular imaging targetsNovel therapeutic approachesNovel diagnostic approachCommon vasculopathyCoronary arteryCoronary segmentsTherapeutic approachesAnimal modelsAnimal studiesVascular pathophysiologyVascular imagingMajor causeVessel wall biologyIntravascular imagingDiseaseImaging targetsPathologyAccessible targetsMolecular imagingSingle-modality imaging
2001
INHIBITION OF INTERFERON-γ–MEDIATED MICROVASCULAR ENDOTHELIAL CELL MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II GENE ACTIVATION BY HMG-COA REDUCTASE INHIBITORS1
Sadeghi M, Tiglio A, Sadigh K, O’Donnell L, Collinge M, Pardi R, Bender J. INHIBITION OF INTERFERON-γ–MEDIATED MICROVASCULAR ENDOTHELIAL CELL MAJOR HISTOCOMPATIBILITY COMPLEX CLASS II GENE ACTIVATION BY HMG-COA REDUCTASE INHIBITORS1. Transplantation 2001, 71: 1262-1268. PMID: 11397960, DOI: 10.1097/00007890-200105150-00014.Peer-Reviewed Original ResearchConceptsMicrovascular endothelial cellsClass II transactivatorInhibitory effectVascular diseaseSimvastatin pretreatmentIFN-gammaReductase inhibitorsClass II major histocompatibility complex moleculesCardiac transplant patientsGraft vascular diseaseLate graft failureHMG-CoA reductase inhibitorsHuman leukocyte antigenEffect of simvastatinMajor histocompatibility complex moleculesHLA-DR inductionSTAT-1 phosphorylationCoA reductase inhibitorsHistocompatibility complex moleculesHuman microvascular endothelial cellsInhibition of interferonTranscription-polymerase chain reaction analysisCardiac transplantationTransplant patientsGraft failure