2022
Deletion of matrix metalloproteinase-12 compromises mechanical homeostasis and leads to an aged aortic phenotype in young mice
Spronck B, Ramachandra AB, Moriyama L, Toczek J, Han J, Sadeghi MM, Humphrey JD. Deletion of matrix metalloproteinase-12 compromises mechanical homeostasis and leads to an aged aortic phenotype in young mice. Journal Of Biomechanics 2022, 141: 111179. PMID: 35759974, PMCID: PMC9585962, DOI: 10.1016/j.jbiomech.2022.111179.Peer-Reviewed Original ResearchConceptsPulse wave velocityAortic phenotypeYoung miceAortic agingMMP-12Matrix metalloproteinasesMMP-12-deficient miceOld adult miceMatrix metalloproteinase-12Biomechanical propertiesAbdominal aortaArterial agingDeficient miceEnd organsBlood flowAdult miceCentral arteriesPercent changeMetalloproteinase-12MiceArterial wallAortaYoung adultsMatrix turnoverStrong proteolytic activityDifferential BMP Signaling Mediates the Interplay Between Genetics and Leaflet Numbers in Aortic Valve Calcification
Jung JJ, Ahmad AA, Rajendran S, Wei L, Zhang J, Toczek J, Nie L, Kukreja G, Salarian M, Gona K, Ghim M, Chakraborty R, Martin KA, Tellides G, Heistad D, Sadeghi MM. Differential BMP Signaling Mediates the Interplay Between Genetics and Leaflet Numbers in Aortic Valve Calcification. JACC Basic To Translational Science 2022, 7: 333-345. PMID: 35540096, PMCID: PMC9079798, DOI: 10.1016/j.jacbts.2021.12.006.Peer-Reviewed Original ResearchBicuspid aortic valveCalcific aortic valve diseaseAortic valve calcificationValve calcificationHuman Calcific Aortic Valve DiseaseAortic valve diseaseValve diseaseAortic valveCAVD progressionTherapeutic targetBone morphogenic proteinMorphogenic proteinMiceCalcificationDCBLD2StenosisExpressionLittermatesDiseaseBMP signalingProgression
2013
Lipid lowering and imaging protease activation in atherosclerosis
Razavian M, Nie L, Challa A, Zhang J, Golestani R, Jung JJ, Robinson S, Sadeghi MM. Lipid lowering and imaging protease activation in atherosclerosis. Journal Of Nuclear Cardiology 2013, 21: 319-328. PMID: 24368425, PMCID: PMC3991560, DOI: 10.1007/s12350-013-9843-7.Peer-Reviewed Original ResearchConceptsHigh-fat dietLipid-lowering interventionsHFD groupPlaque inflammationAtherosclerotic miceMicroSPECT/CT imagingTotal blood cholesterolModern therapeutic approachesSmooth muscle αMMP tracerFat dietBlood cholesterolPlaque biologyTherapeutic approachesTracer uptakeMatrix metalloproteinaseTherapeutic interventionsAtherosclerosisActin expressionCT imagingMuscle αWeeksFenofibrateMiceIntervention
2007
Activated αvβ3 Integrin Targeting in Injury-Induced Vascular Remodeling
Sadeghi MM, Bender JR. Activated αvβ3 Integrin Targeting in Injury-Induced Vascular Remodeling. Trends In Cardiovascular Medicine 2007, 17: 5-10. PMID: 17210471, DOI: 10.1016/j.tcm.2006.07.003.Peer-Reviewed Original Research