1999
Insulin-like growth factor I stimulates cardiac myosin heavy chain and actin synthesis in the awake rat
Young L, Renfu Y, Hu X, Chong S, Hasan S, Jacob R, Sherwin R. Insulin-like growth factor I stimulates cardiac myosin heavy chain and actin synthesis in the awake rat. American Journal Of Physiology 1999, 276: e143-e150. PMID: 9886960, DOI: 10.1152/ajpendo.1999.276.1.e143.Peer-Reviewed Original ResearchConceptsInsulin-like growth factor IGrowth factor IAwake ratsMyosin heavy chainFactor IContractile protein synthesisIGF-I infusionLow-dose IGFMixed cardiac proteinsCardiac myosin heavy chainMyosin synthesisBlood pressureOvernight fastIntravenous infusionRight ventricleHeavy chainHeart rateHypoglycemic effectFed ratsIGFRatsDirect actionProtein synthesisSalineCardiac proteins
1993
Response of rat heart and skeletal muscle protein in vivo to insulin and amino acid infusion
McNulty PH, Young LH, Barrett EJ. Response of rat heart and skeletal muscle protein in vivo to insulin and amino acid infusion. American Journal Of Physiology 1993, 264: e958-e965. PMID: 8333520, DOI: 10.1152/ajpendo.1993.264.6.e958.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGlucoseInsulinLeucineMaleMuscle ProteinsMusclesMyocardiumOsmolar ConcentrationPhenylalanineRatsRats, Sprague-DawleyConceptsAmino acid infusionMuscle protein synthesisContinuous infusionAcid infusionNet muscle protein synthesisSaline-treated ratsSkeletal muscle protein synthesisInfusion of insulinPlasma specific activitySkeletal muscle proteinsProtein synthesisAmino acid solutionMature ratsInfusionRat heartInsulinBolusTracer infusionHeart muscleSkeletal muscleTracer infusion methodRatsPhysiological concentrationsAmino acids
1989
Physiologic hyperinsulinemia stimulates lactate extraction by heart muscle in the conscious dog
Young L, Zaret B, Barrett E. Physiologic hyperinsulinemia stimulates lactate extraction by heart muscle in the conscious dog. Metabolism 1989, 38: 1115-1119. PMID: 2682138, DOI: 10.1016/0026-0495(89)90049-8.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsConsciousnessDogsFatty Acids, NonesterifiedGlucoseInsulinLactatesLactic AcidMyocardiumOsmolar ConcentrationConceptsPhysiologic hyperinsulinemiaConscious dogsFree fatty acidsArterial free fatty acid concentrationMumol/minHeart muscleArterial plasma insulinMyocardial lactate uptakeFree fatty acid concentrationsArterial lactate concentrationHyperinsulinemic-euglycemic clampMyocardial glucose uptakeHyperinsulinemia increasesEuglycemic hyperinsulinemiaNormal heart muscleEuglycemic clampFatty acidsPlasma insulinBasal measurementsBlood glucoseLactate extractionFatty acid concentrationsMyocardial uptakeLactate uptakeHyperinsulinemia
1987
Myocardial amino acid transport by canine sarcolemma vesicles
Young LH, Zaret BL, Barrett EJ. Myocardial amino acid transport by canine sarcolemma vesicles. American Journal Of Physiology 1987, 252: h1070-h1076. PMID: 3035946, DOI: 10.1152/ajpheart.1987.252.6.h1070.Peer-Reviewed Original ResearchConceptsCanine ventricular myocardiumVentricular myocardiumSarcoplasmic reticulumSarcolemma vesiclesLeucine uptakeAmino acid uptakeL-leucineDependent alanine transport activityAmino acid transportX minStimulatory effectPmol xAcid uptakeMammalian heartSaturable functionMyocardiumAcid transportSarcolemmaLeucine transportAlanine transport activityAlanine fluxMembrane vesiclesDifferent membrane preparations