2007
Screening for Coronary Artery Disease in Patients With Diabetes
Bax JJ, Young LH, Frye RL, Bonow RO, Steinberg HO, Barrett EJ. Screening for Coronary Artery Disease in Patients With Diabetes. Diabetes Care 2007, 30: 2729-2736. PMID: 17901530, DOI: 10.2337/dc07-9927.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCoronary artery diseaseArtery diseaseCardiovascular diseaseHigh-risk coronary artery diseaseStable coronary artery diseaseCoronary artery calcium scoringAdditive survival benefitIntensive medical managementRecognition of diabetesCVD risk reductionPercutaneous coronary revascularizationStrong clinical suspicionAmerican Diabetes AssociationType 2 diabetesClinical trial resultsCost of diabetesAsymptomatic patientsAtherosclerotic burdenCoronary revascularizationCardiac eventsClinical suspicionCoronary atherosclerosisDiabetic populationSurvival benefitAsymptomatic atherosclerosis
2006
Diabetes Mellitus and Cardiovascular Disease
Chyun DA, Young LH. Diabetes Mellitus and Cardiovascular Disease. Nursing Clinics Of North America 2006, 41: 681-695. PMID: 17059982, DOI: 10.1016/j.cnur.2006.07.007.BooksConceptsCoronary heart diseaseCardiovascular diseaseHeart diseasePeripheral vascular diseaseAcute myocardial infarctionMultiple risk factorsComplex pathophysiologic processHeart failureChronic manifestationsMyocardial infarctionVascular diseaseRisk factorsPathophysiologic processesSudden deathHigh riskType 1DiseaseEarly detectionDiabetesHypertensionMellitusInfarctionStrokeIndividualsPrevention
2004
Detection of Silent Myocardial Ischemia in Asymptomatic Diabetic Subjects
Wackers FJ, Young LH, Inzucchi SE, Chyun DA, Davey JA, Barrett EJ, Taillefer R, Wittlin SD, Heller GV, Filipchuk N, Engel S, Ratner RE, Iskandrian AE. Detection of Silent Myocardial Ischemia in Asymptomatic Diabetic Subjects. Diabetes Care 2004, 27: 1954-1961. PMID: 15277423, DOI: 10.2337/diacare.27.8.1954.Peer-Reviewed Original ResearchConceptsSilent myocardial ischemiaType 2 diabetesCardiac risk factorsMyocardial ischemiaAsymptomatic patientsSilent ischemiaNormal perfusionRisk factorsTraditional cardiac risk factorsAmerican Diabetes Association guidelinesTomography myocardial perfusion imagingRegional myocardial perfusion abnormalitiesAbnormal stress testAsymptomatic diabetic subjectsAsymptomatic Diabetics (DIAD) studyCurrent American Diabetes AssociationPrevalence of ischemiaCardiac autonomic dysfunctionLarge perfusion defectsST-segment depressionCoronary artery diseaseAmerican Diabetes AssociationMyocardial perfusion abnormalitiesMyocardial perfusion imagingStrongest predictor
2003
Diagnosis of CAD in patients with diabetes: Who to evaluate
Young LH, Jose P, Chyun D. Diagnosis of CAD in patients with diabetes: Who to evaluate. Current Diabetes Reports 2003, 3: 19-27. PMID: 12643142, DOI: 10.1007/s11892-003-0048-3.BooksMeSH KeywordsCoronary DiseaseDiabetes ComplicationsHeart Function TestsHumansMass ScreeningMyocardial IschemiaPrognosisRisk FactorsConceptsCoronary artery diseaseCardiac testingDiabetic patientsDiagnosis of CADNoninvasive cardiac testingManagement of patientsCAD screeningAsymptomatic ischemiaAsymptomatic patientsSymptomatic patientsArtery diseaseCardiac catheterizationRisk stratificationPatientsAccurate diagnosisDiagnosisAppropriate useDiabetesEffective diagnosisCurrent controversiesRecent informationRevascularizationCatheterizationIschemiaClinicians
2000
Effect of hyperinsulinemia on myocardial amino acid uptake in patients with coronary artery disease
McNulty P, Jacob R, Deckelbaum L, Young L. Effect of hyperinsulinemia on myocardial amino acid uptake in patients with coronary artery disease. Metabolism 2000, 49: 1365-1369. PMID: 11079831, DOI: 10.1053/meta.2000.9510.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmino Acids, Branched-ChainBlood GlucoseCoronary DiseaseGlucoseHemodynamicsHumansHyperinsulinismMaleMiddle AgedMyocardiumConceptsBranched-chain amino acidsIschemic heart diseaseMyocardial uptakeArterial plasmaHeart diseaseChronic ischemic heart diseaseCoronary artery diseasePlasma BCAA concentrationsEffect of hyperinsulinemiaMyocardial glucose uptakeNet myocardial uptakeEuglycemic insulin infusionsNet glutamate uptakeOxidative energy substratesPossible salutary effectsBCAA uptakeMyocardial utilizationEuglycemic hyperinsulinemiaArtery diseaseInsulin levelsBCAA concentrationsInsulin infusionAmino acid uptakeAnabolic effectsCardiovascular disease
1996
Glucose metabolism distal to a critical coronary stenosis in a canine model of low-flow myocardial ischemia.
McNulty PH, Sinusas AJ, Shi CQ, Dione D, Young LH, Cline GC, Shulman GI. Glucose metabolism distal to a critical coronary stenosis in a canine model of low-flow myocardial ischemia. Journal Of Clinical Investigation 1996, 98: 62-69. PMID: 8690805, PMCID: PMC507401, DOI: 10.1172/jci118778.Peer-Reviewed Original ResearchConceptsLow-flow ischemiaCoronary stenosisIschemic myocardiumIschemic regionLow-flow myocardial ischemiaCritical coronary stenosisExogenous glucoseOxidative substrateMyocardial ischemiaIntact dogsGlucose metabolismNonischemic regionsClinical observationsCanine modelGlucose utilizationIschemiaBiochemical measurementsMyocardial regionsRate of incorporationIntracellular metabolismTricarboxylic acid cycle fluxStenosisMyocardiumGlucoseGlucose-derived pyruvate
1995
Hyperinsulinemia inhibits myocardial protein degradation in patients with cardiovascular disease and insulin resistance.
McNulty P, Louard R, Deckelbaum L, Zaret B, Young L. Hyperinsulinemia inhibits myocardial protein degradation in patients with cardiovascular disease and insulin resistance. Circulation 1995, 92: 2151-6. PMID: 7554195, DOI: 10.1161/01.cir.92.8.2151.Peer-Reviewed Original ResearchConceptsMyocardial protein degradationInsulin infusionCardiovascular diseaseMyocardial protein synthesisInsulin resistancePhenylalanine balanceMyocardial hypertrophyWhole-body glucose metabolismCoronary artery diseaseIschemic heart diseasePlasma insulin concentrationNet phenylalanine balanceWhole-body carbohydrate metabolismEffect of insulinMyocardial protein metabolismArtery diseaseAcute hyperinsulinemiaProtein synthesisHeart diseaseInsulin concentrationsPlasma concentrationsAntiproteolytic actionHyperinsulinemiaGlucose metabolismConstant infusion
1991
Myocardial protein turnover in patients with coronary artery disease. Effect of branched chain amino acid infusion.
Young LH, McNulty PH, Morgan C, Deckelbaum LI, Zaret BL, Barrett EJ. Myocardial protein turnover in patients with coronary artery disease. Effect of branched chain amino acid infusion. Journal Of Clinical Investigation 1991, 87: 554-560. PMID: 1991838, PMCID: PMC296343, DOI: 10.1172/jci115030.Peer-Reviewed Original ResearchConceptsBranched-chain amino acid infusionCoronary artery diseaseAmino acid infusionProtein turnoverBCAA infusionProtein synthesisArtery diseaseAcid infusionAmino acidsMyocardial protein turnoverCardiac double productCoronary blood flowPlasma insulin levelsMyocardial oxygen consumptionHuman heartProtein degradationNegative protein balanceEssential amino acidsMyocardial balanceInsulin levelsDouble productPhenylalanine balanceAnabolic effectsMyocardial uptakePostabsorptive patients
1990
Metabolic and functional effects of perfluorocarbon distal perfusion during coronary angioplasty
Young L, Jaffe C, Revkin J, McNulty P, Cleman M. Metabolic and functional effects of perfluorocarbon distal perfusion during coronary angioplasty. The American Journal Of Cardiology 1990, 65: 986-990. PMID: 2327360, DOI: 10.1016/0002-9149(90)91001-m.Peer-Reviewed Original ResearchConceptsGreat cardiac veinDistal perfusionLactate releaseEjection fractionVentricular functionCardiac veinBalloon inflationLeft ventricular ejection fractionDistal coronary perfusionMyocardial lactate metabolismVentricular ejection fractionMyocardial lactate releaseRegional contractile functionNet lactate extractionNet lactate releaseCoronary angioplastyLeft anteriorCoronary perfusionLactate extractionContractile functionPerfusionAngioplastyLactate concentrationLactate metabolismOxygenated perfluorocarbon