2000
Effect of hyperinsulinemia on myocardial amino acid uptake in patients with coronary artery disease
McNulty P, Jacob R, Deckelbaum L, Young L. Effect of hyperinsulinemia on myocardial amino acid uptake in patients with coronary artery disease. Metabolism 2000, 49: 1365-1369. PMID: 11079831, DOI: 10.1053/meta.2000.9510.Peer-Reviewed Original ResearchConceptsBranched-chain amino acidsIschemic heart diseaseMyocardial uptakeArterial plasmaHeart diseaseChronic ischemic heart diseaseCoronary artery diseasePlasma BCAA concentrationsEffect of hyperinsulinemiaMyocardial glucose uptakeNet myocardial uptakeEuglycemic insulin infusionsNet glutamate uptakeOxidative energy substratesPossible salutary effectsBCAA uptakeMyocardial utilizationEuglycemic hyperinsulinemiaArtery diseaseInsulin levelsBCAA concentrationsInsulin infusionAmino acid uptakeAnabolic effectsCardiovascular disease
1994
Effect of insulin on rat heart and skeletal muscle phenylalanyl-tRNA labeling and protein synthesis in vivo
Young LH, Stirewalt W, McNulty PH, Revkin JH, Barrett EJ. Effect of insulin on rat heart and skeletal muscle phenylalanyl-tRNA labeling and protein synthesis in vivo. American Journal Of Physiology 1994, 267: e337-e342. PMID: 8074214, DOI: 10.1152/ajpendo.1994.267.2.e337.Peer-Reviewed Original ResearchConceptsMuscle protein synthesisAcid-soluble poolFemoral venous plasmaSkeletal muscleSkeletal muscle protein synthesisEffect of insulinMuscle protein hydrolysateProtein synthesisContinuous infusionVenous plasmaHyperinsulinemic clampSaline infusionAnesthetized ratsArterial plasmaRat heartInsulin effectInsulinHormonal regulationHeartInfusionMuscleSpecific activityMinVivo measurementsLabeling