2024
Adverse cardiovascular events and cardiac imaging findings in patients on immune checkpoint inhibitors
Kwan J, Shen M, Akhlaghi N, Hu J, Mora R, Cross J, Jiang M, Mankbadi M, Wang P, Zaman S, Lee S, Im Y, Feher A, Liu Y, S. S, Tao W, Wei W, Baldassarre L. Adverse cardiovascular events and cardiac imaging findings in patients on immune checkpoint inhibitors. PLOS ONE 2024, 19: e0314555. PMID: 39621799, PMCID: PMC11611253, DOI: 10.1371/journal.pone.0314555.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiovascular DiseasesEchocardiographyFemaleHumansImmune Checkpoint InhibitorsMagnetic Resonance ImagingMaleMiddle AgedNeoplasmsRetrospective StudiesRisk FactorsConceptsAdverse cardiovascular eventsICI therapyCardiac magnetic resonanceIncreased risk of mortalityICI initiationIncreased riskRisk of mortalityCentral nervous systemVentricular dysfunctionCancer patients treated with ICIsCardiovascular eventsLeft ventricular late gadolinium enhancementMortality benefitCardiovascular riskAbnormal left ventricular ejection fractionPatients treated with ICIsLeft ventricular ejection fractionCentral nervous system malignanciesRisk of adverse cardiovascular eventsImmune checkpoint inhibitorsRight ventricular dysfunctionGlobal longitudinal strainVentricular ejection fractionLeft ventricular dysfunctionMultimodality cardiac imagingDiastolic dysfunction evaluation by cardiovascular magnetic resonance derived E, a, e’: Comparison to echocardiography
Lamy J, Xiang J, Shah N, Kwan J, Kim Y, Upadhyaya K, Reinhardt S, Meadows J, McNamara R, Baldassarre L, Peters D. Diastolic dysfunction evaluation by cardiovascular magnetic resonance derived E, a, e’: Comparison to echocardiography. Physiological Reports 2024, 12: e70078. PMID: 39604208, PMCID: PMC11602526, DOI: 10.14814/phy2.70078.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedDiastoleEchocardiographyFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesVentricular Dysfunction, LeftConceptsCardiovascular magnetic resonanceTransthoracic echocardiographyDiastolic dysfunctionDiastolic functionDiagnostic accuracy of cardiovascular magnetic resonanceEvaluate diastolic dysfunctionCardiovascular magnetic resonance imagingLeft atrial volumeMitral annular velocityHealthy age-matched subjectsComparison to echocardiographyMitral inflow velocityEvaluate diastolic functionAge-matched subjectsPresence of DDAtrial volumeDD gradeFirst-lineAnnular velocityDiagnostic accuracyImaging modalitiesMagnetic resonanceEchocardiographyALLTransthoracic
2023
Atrial fibrosis by cardiac MRI is a correlate for atrial stiffness in patients with atrial fibrillation
Lamy J, Taoutel R, Chamoun R, Akar J, Niederer S, Mojibian H, Huber S, Baldassarre L, Meadows J, Peters D. Atrial fibrosis by cardiac MRI is a correlate for atrial stiffness in patients with atrial fibrillation. The International Journal Of Cardiovascular Imaging 2023, 40: 107-117. PMID: 37857929, PMCID: PMC11378145, DOI: 10.1007/s10554-023-02968-x.Peer-Reviewed Original ResearchMeSH KeywordsAtrial FibrillationCatheter AblationContrast MediaFibrosisGadoliniumHeart AtriaHumansMagnetic Resonance ImagingPredictive Value of TestsConceptsLate gadolinium enhancementLA reservoir strainLeft atrial pressureLA volumeReservoir strainLA fibrosisLA strainStiffness indexLA late gadolinium enhancementAtrial stiffness indexMaximal LA volumeAtrial fibrillation cohortLA minimum volumeAtrial tissue fibrosisMaximum LA volumeCardiac MR examsAtrial stiffnessAtrial strainAF ablationAtrial pressureAF cohortAtrial fibrillationAtrial fibrosisPatient subgroupsLGE volumeImpaired left-ventricular global longitudinal strain by feature-tracking cardiac MRI predicts mortality in systemic sclerosis
Feher A, Miller E, Peters D, Mojibian H, Sinusas A, Hinchcliff M, Baldassarre L. Impaired left-ventricular global longitudinal strain by feature-tracking cardiac MRI predicts mortality in systemic sclerosis. Rheumatology International 2023, 43: 849-858. PMID: 36894756, DOI: 10.1007/s00296-023-05294-6.Peer-Reviewed Original ResearchConceptsLate gadolinium enhancementLV-GLSSystemic sclerosisWorse survivalClinical indicationsImpaired left ventricular global longitudinal strainLeft ventricular global longitudinal strainPresence of LGECMR strainLV cardiac indexWorse LV-GLSLV ejection fractionCox regression analysisGlobal longitudinal strainLV cardiac outputGlobal radialCardiac indexOverall survivalRetrospective cohortEjection fractionPrognostic valueAdverse outcomesCardiac outputGadolinium enhancementRV strainMyocardial Injury on CMR in Patients With COVID-19 and Suspected Cardiac Involvement
Vidula M, Rajewska-Tabor J, Cao J, Kang Y, Craft J, Mei W, Chandrasekaran P, Clark D, Poenar A, Gorecka M, Malahfji M, Cowan E, Kwan J, Reinhardt S, Al-Tabatabaee S, Doeblin P, Villa A, Karagodin I, Alvi N, Christia P, Spetko N, Cassar M, Park C, Nambiar L, Turgut A, Azad M, Lambers M, Wong T, Salerno M, Kim J, Elliott M, Raman B, Neubauer S, Tsao C, LaRocca G, Patel A, Chiribiri A, Kelle S, Baldassarre L, Shah D, Hughes S, Tong M, Pyda M, Simonetti O, Plein S, Han Y. Myocardial Injury on CMR in Patients With COVID-19 and Suspected Cardiac Involvement. JACC Cardiovascular Imaging 2023, 16: 609-624. PMID: 36752429, PMCID: PMC9833283, DOI: 10.1016/j.jcmg.2022.10.021.Peer-Reviewed Original ResearchMeSH KeywordsCoronary Artery DiseaseCOVID-19Heart InjuriesHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMyocarditisPredictive Value of TestsRetrospective StudiesTroponinConceptsCardiac magnetic resonanceNatriuretic peptide elevationMyocardial injuryIschemic patternTroponin elevationCardiac involvementChest discomfortInjury patternsCOVID-19Cardiac biomarker elevationCOVID-19 infectionAcute myocarditisAcute ischemicBiomarker elevationCardiac symptomsClinical suspicionCoronary diseaseMulticenter cohortAbnormal electrocardiogramMulticenter studyRetrospective studyECG abnormalitiesUnivariate analysisPatientsMultivariate analysis
2021
Left atrial evaluation by cardiovascular magnetic resonance: sensitive and unique biomarkers
Peters DC, Lamy J, Sinusas AJ, Baldassarre LA. Left atrial evaluation by cardiovascular magnetic resonance: sensitive and unique biomarkers. European Heart Journal - Cardiovascular Imaging 2021, 23: 14-30. PMID: 34718484, PMCID: PMC8685602, DOI: 10.1093/ehjci/jeab221.Peer-Reviewed Original ResearchMeSH KeywordsAtrial FibrillationBiomarkersCatheter AblationContrast MediaFibrosisGadoliniumHeart AtriaHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyReproducibility of ResultsConceptsLate gadolinium enhancementAtrial fibrillationCardiovascular magnetic resonanceDiastolic dysfunctionEjection fractionAF recurrenceAtrial fibrosisNew-onset atrial fibrillationPost-operative atrial fibrillationLongitudinal LA strainExtent of fibrosisLong-axis cine imagesCine imagesAtrial imagingCardiovascular eventsLA volumeRisk stratificationAF subjectsPrognostic informationHypertrophic cardiomyopathyLA strainGadolinium enhancementSensitive markerAblation proceduresMagnetic resonanceFat-saturated dark-blood cardiac T2 mapping in a single breath-hold
Hu C, Huber S, Nguyen V, Baldassarre L, Mojibian H, Peters D. Fat-saturated dark-blood cardiac T2 mapping in a single breath-hold. Magnetic Resonance Imaging 2021, 81: 24-32. PMID: 34044065, DOI: 10.1016/j.mri.2021.05.004.Peer-Reviewed Original ResearchCardiovascular magnetic resonance in women with cardiovascular disease: position statement from the Society for Cardiovascular Magnetic Resonance (SCMR)
Ordovas KG, Baldassarre LA, Bucciarelli-Ducci C, Carr J, Fernandes JL, Ferreira VM, Frank L, Mavrogeni S, Ntusi N, Ostenfeld E, Parwani P, Pepe A, Raman SV, Sakuma H, Schulz-Menger J, Sierra-Galan LM, Valente AM, Srichai MB. Cardiovascular magnetic resonance in women with cardiovascular disease: position statement from the Society for Cardiovascular Magnetic Resonance (SCMR). Journal Of Cardiovascular Magnetic Resonance 2021, 23: 52. PMID: 33966639, PMCID: PMC8108343, DOI: 10.1186/s12968-021-00746-z.Peer-Reviewed Original ResearchMeSH KeywordsCardiovascular DiseasesFemaleHeart Defects, CongenitalHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMalePredictive Value of TestsConceptsCardiovascular magnetic resonanceCardiovascular diseaseFemale patientsPosition statementHeart diseaseCancer therapy-related cardiac dysfunctionClinical scenariosStable ischemic heart diseaseUse of CMRAcute coronary syndromeSystemic rheumatic diseasesIschemic heart diseaseBicuspid aortic valveCongenital heart diseaseSpecific clinical scenariosMagnetic resonanceAortic syndromeCoronary syndromePeripartum cardiomyopathyCardiac dysfunctionRheumatic diseasesClinical evidenceAortic valveVascular disordersClinical careLeft ventricular myocardial strain and tissue characterization by cardiac magnetic resonance imaging in immune checkpoint inhibitor associated cardiotoxicity
Higgins AY, Arbune A, Soufer A, Ragheb E, Kwan JM, Lamy J, Henry M, Cuomo JR, Charifa A, Gallegos C, Hull S, Coviello JS, Bader AS, Peters DC, Huber S, Mojibian HR, Sinusas AJ, Kluger H, Baldassarre LA. Left ventricular myocardial strain and tissue characterization by cardiac magnetic resonance imaging in immune checkpoint inhibitor associated cardiotoxicity. PLOS ONE 2021, 16: e0246764. PMID: 33606757, PMCID: PMC7895343, DOI: 10.1371/journal.pone.0246764.Peer-Reviewed Original ResearchConceptsGlobal longitudinal strainImmune checkpoint inhibitorsLate gadolinium enhancementRecovery of LVEFLake Louise criteriaCheckpoint inhibitorsNormal LVEFAverage global longitudinal strainPresence of LGEAbnormal global longitudinal strainCardiac magnetic resonance imagingCorrect clinical contextEvaluation of myocarditisLeft ventricular dysfunctionVentricular ejection fractionDiagnosis of myocarditisLeft ventricular strainCardiac magnetic resonanceLeft ventricular myocardial strainOvert left ventricular dysfunctionVentricular myocardial strainMagnetic resonance imagingAtrial strainVentricular dysfunctionVentricular strain
2020
Cardiovascular disease in women: insights from magnetic resonance imaging
Bucciarelli-Ducci C, Ostenfeld E, Baldassarre LA, Ferreira VM, Frank L, Kallianos K, Raman SV, Srichai MB, McAlindon E, Mavrogeni S, Ntusi NAB, Schulz-Menger J, Valente AM, Ordovas KG. Cardiovascular disease in women: insights from magnetic resonance imaging. Journal Of Cardiovascular Magnetic Resonance 2020, 22: 71. PMID: 32981527, PMCID: PMC7520984, DOI: 10.1186/s12968-020-00666-4.Peer-Reviewed Original ResearchConceptsCardiovascular magnetic resonanceCardiovascular diseaseValue of CMRRole of CMRPulmonary arterial hypertensionUnique diagnostic challengeConnective tissue disordersMagnetic resonance imagingArterial hypertensionPeripartum cardiomyopathyUnderrecognized conditionCardiovascular differencesPrognostic roleFemale patientsPatient populationDiagnostic challengeTissue disordersCardiovascular disordersResonance imagingClinical mismanagementDiseaseImaging modalitiesWomenSex differencesFurther investigation
2019
Valvular imaging in the era of feature‐tracking: A slice‐following cardiac MR sequence to measure mitral flow
Seemann F, Heiberg E, Carlsson M, Gonzales RA, Baldassarre LA, Qiu M, Peters DC. Valvular imaging in the era of feature‐tracking: A slice‐following cardiac MR sequence to measure mitral flow. Journal Of Magnetic Resonance Imaging 2019, 51: 1412-1421. PMID: 31654470, PMCID: PMC7217167, DOI: 10.1002/jmri.26971.Peer-Reviewed Original ResearchMeSH KeywordsBlood Flow VelocityHumansMagnetic Resonance ImagingMitral Valve InsufficiencyProspective StudiesReproducibility of ResultsRetrospective StudiesConceptsMitral valve dysfunctionAortic stroke volumeStroke volumeHealthy subjectsValve dysfunctionMitral flowMitral valveMitral flow patternTransmitral blood flowMitral stroke volumeStage 2 J. MagnDiastolic functionMitral regurgitationTransmitral flowCine phase contrastDysfunction patientsClinical examinationBland-Altman analysisPhase-contrast sequenceBlood flowJ. MagnImportant clinical examinationTechnical efficacyPatientsT-testPresentation of Liver Failure From a Pericardial Mass
Nguyen VQ, Workman V, Stendahl K, Young L, Sklar J, Baldassarre LA. Presentation of Liver Failure From a Pericardial Mass. Circulation Cardiovascular Imaging 2019, 12: e008672. PMID: 31167559, DOI: 10.1161/circimaging.118.008672.Peer-Reviewed Case Reports and Technical NotesNuclear cardiology in the context of multimodality imaging to detect cardiac toxicity from cancer therapeutics: Established and emerging methods
Soufer A, Liu C, Henry ML, Baldassarre LA. Nuclear cardiology in the context of multimodality imaging to detect cardiac toxicity from cancer therapeutics: Established and emerging methods. Journal Of Nuclear Cardiology 2019, 27: 1210-1224. PMID: 30868378, DOI: 10.1007/s12350-019-01671-6.Peer-Reviewed Original ResearchConceptsCardiac toxicityPre-clinical cardiotoxicityCardiac magnetic resonanceNuclear cardiologyCardiovascular outcomesNon-invasive imagingCardiovascular toxicityChemotherapeutic agentsCancer treatmentEarly detectionCardiac imagingCancer therapyCancer therapeuticsCardiologyToxicityMagnetic resonanceTreatmentImagingEchocardiographyPatientsCardiotoxicityTherapyCancerSeverityCareUsing FDG-PET to guide targeted cardiac magnetic resonance imaging in patients with suspected cardiac sarcoidosis
Sharp MB, Soufer A, Abdelmessih M, Rosenfeld LE, Baldassarre LA, Miller EJ. Using FDG-PET to guide targeted cardiac magnetic resonance imaging in patients with suspected cardiac sarcoidosis. Journal Of Nuclear Cardiology 2019, 27: 688-690. PMID: 30737635, DOI: 10.1007/s12350-019-01640-z.Peer-Reviewed Original Research
2018
REPAIRit: Improving Myocardial Nulling and Ghosting Artifacts of 3D Navigator‐Gated Late Gadolinium Enhancement Imaging During Arrhythmia
Hu C, Huber S, Latif SR, Santacana‐Laffitte G, Mojibian HR, Baldassarre LA, Peters DC. REPAIRit: Improving Myocardial Nulling and Ghosting Artifacts of 3D Navigator‐Gated Late Gadolinium Enhancement Imaging During Arrhythmia. Journal Of Magnetic Resonance Imaging 2018, 49: 688-699. PMID: 30252987, DOI: 10.1002/jmri.26284.Peer-Reviewed Original ResearchAssessment of diastolic function and atrial remodeling by MRI – validation and correlation with echocardiography and filling pressure
Seemann F, Baldassarre LA, Llanos‐Chea F, Gonzales RA, Grunseich K, Hu C, Sugeng L, Meadows J, Heiberg E, Peters DC. Assessment of diastolic function and atrial remodeling by MRI – validation and correlation with echocardiography and filling pressure. Physiological Reports 2018, 6: e13828. PMID: 30187654, PMCID: PMC6125607, DOI: 10.14814/phy2.13828.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAtrial RemodelingContrast MediaDiastoleEchocardiographyFemaleFibrosisGadoliniumHeart DiseasesHumansMagnetic Resonance ImagingMaleMiddle AgedReproducibility of ResultsConceptsLate gadolinium enhancementMagnetic resonance imagingPulmonary capillary wedge pressureLA late gadolinium enhancementCapillary wedge pressureTransthoracic echocardiographyDiastolic functionDiastolic parametersWedge pressureAtrial remodelingFilling pressureCardiovascular magnetic resonance imagingLeft atrial remodelingVentricular filling pressureAtrial late gadolinium enhancementLGE-magnetic resonance imagingDiastolic dysfunctionMedical chartsLA volumeAtrial fibrosisGadolinium enhancementResonance imagingPressure catheterizationLow interobserverEchocardiography
2017
Diagnosis of extensive myocardial infiltration by diffuse large B-cell lymphoma using 18F-fluorodeoxyglucose positron emission tomography (18-FDG PET)
Higgins AY, Taylor EP, Baldassarre LA, Miller EJ, Rosenfeld LE. Diagnosis of extensive myocardial infiltration by diffuse large B-cell lymphoma using 18F-fluorodeoxyglucose positron emission tomography (18-FDG PET). Journal Of Nuclear Cardiology 2017, 25: 1869-1871. PMID: 29116563, DOI: 10.1007/s12350-017-1099-1.Peer-Reviewed Case Reports and Technical NotesReverse double inversion‐recovery: Improving motion robustness of cardiac T2‐weighted dark‐blood turbo spin‐echo sequence
Hu C, Huber S, Latif SR, Santacana‐Laffitte G, Mojibian HR, Baldassarre LA, Peters DC. Reverse double inversion‐recovery: Improving motion robustness of cardiac T2‐weighted dark‐blood turbo spin‐echo sequence. Journal Of Magnetic Resonance Imaging 2017, 47: 1498-1508. PMID: 29112315, PMCID: PMC6346424, DOI: 10.1002/jmri.25886.Peer-Reviewed Original ResearchAdultAgedAlgorithmsArtifactsComputer SimulationDiastoleFemaleHealthy VolunteersHeartHeart DiseasesHeart VentriclesHumansImage EnhancementImage Interpretation, Computer-AssistedImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedMotionMyocardiumProspective StudiesQuality ControlReproducibility of ResultsSignal-To-Noise Ratio
2016
Serial Native T1 Mapping to Monitor Cardiac Response to Treatment in Light-Chain Amyloidosis
Hur DJ, Dicks DL, Huber S, Mojibian HR, Meadows JL, Seropian SE, Baldassarre LA. Serial Native T1 Mapping to Monitor Cardiac Response to Treatment in Light-Chain Amyloidosis. Circulation Cardiovascular Imaging 2016, 9: e004770. PMID: 27682238, DOI: 10.1161/circimaging.116.004770.Peer-Reviewed Original Research