2024
Adverse cardiovascular events and cardiac imaging findings in patients on immune checkpoint inhibitors
Kwan J, Shen M, Akhlaghi N, Hu J, Mora R, Cross J, Jiang M, Mankbadi M, Wang P, Zaman S, Lee S, Im Y, Feher A, Liu Y, S. S, Tao W, Wei W, Baldassarre L. Adverse cardiovascular events and cardiac imaging findings in patients on immune checkpoint inhibitors. PLOS ONE 2024, 19: e0314555. PMID: 39621799, PMCID: PMC11611253, DOI: 10.1371/journal.pone.0314555.Peer-Reviewed Original ResearchConceptsAdverse cardiovascular eventsICI therapyCardiac magnetic resonanceIncreased risk of mortalityICI initiationIncreased riskRisk of mortalityCentral nervous systemVentricular dysfunctionCancer patients treated with ICIsCardiovascular eventsLeft ventricular late gadolinium enhancementMortality benefitCardiovascular riskAbnormal left ventricular ejection fractionPatients treated with ICIsLeft ventricular ejection fractionCentral nervous system malignanciesRisk of adverse cardiovascular eventsImmune checkpoint inhibitorsRight ventricular dysfunctionGlobal longitudinal strainVentricular ejection fractionLeft ventricular dysfunctionMultimodality cardiac imagingDiastolic dysfunction evaluation by cardiovascular magnetic resonance derived E, a, e’: Comparison to echocardiography
Lamy J, Xiang J, Shah N, Kwan J, Kim Y, Upadhyaya K, Reinhardt S, Meadows J, McNamara R, Baldassarre L, Peters D. Diastolic dysfunction evaluation by cardiovascular magnetic resonance derived E, a, e’: Comparison to echocardiography. Physiological Reports 2024, 12: e70078. PMID: 39604208, PMCID: PMC11602526, DOI: 10.14814/phy2.70078.Peer-Reviewed Original ResearchConceptsCardiovascular magnetic resonanceTransthoracic echocardiographyDiastolic dysfunctionDiastolic functionDiagnostic accuracy of cardiovascular magnetic resonanceEvaluate diastolic dysfunctionCardiovascular magnetic resonance imagingLeft atrial volumeMitral annular velocityHealthy age-matched subjectsComparison to echocardiographyMitral inflow velocityEvaluate diastolic functionAge-matched subjectsPresence of DDAtrial volumeDD gradeFirst-lineAnnular velocityDiagnostic accuracyImaging modalitiesMagnetic resonanceEchocardiographyALLTransthoracic
2023
SGLT2 Inhibitor Use and Risk of Clinical Events in Patients With Cancer Therapy–Related Cardiac Dysfunction
Avula V, Sharma G, Kosiborod M, Vaduganathan M, Neilan T, Lopez T, Dent S, Baldassarre L, Scherrer-Crosbie M, Barac A, Liu J, Deswal A, Khadke S, Yang E, Ky B, Lenihan D, Nohria A, Dani S, Ganatra S. SGLT2 Inhibitor Use and Risk of Clinical Events in Patients With Cancer Therapy–Related Cardiac Dysfunction. JACC Heart Failure 2023, 12: 67-78. PMID: 37897456, DOI: 10.1016/j.jchf.2023.08.026.Peer-Reviewed Original ResearchConceptsCancer therapy-related cardiac dysfunctionSGLT2 inhibitor useGuideline-directed medical therapyHeart failureInhibitor useSGLT2 inhibitorsMedical therapyCardiac dysfunctionAntineoplastic therapyAtrial fibrillation/flutterType 2 diabetes mellitusAcute HF exacerbationCox proportional HRsAcute kidney injuryRenal replacement therapyRetrospective cohort analysisIschemic heart diseaseRisk of cardiomyopathyAggregate patient dataTriNetX Research NetworkProportional HRsCause hospitalizationCause mortalityHF exacerbationKidney injuryImpaired left-ventricular global longitudinal strain by feature-tracking cardiac MRI predicts mortality in systemic sclerosis
Feher A, Miller E, Peters D, Mojibian H, Sinusas A, Hinchcliff M, Baldassarre L. Impaired left-ventricular global longitudinal strain by feature-tracking cardiac MRI predicts mortality in systemic sclerosis. Rheumatology International 2023, 43: 849-858. PMID: 36894756, DOI: 10.1007/s00296-023-05294-6.Peer-Reviewed Original ResearchConceptsLate gadolinium enhancementLV-GLSSystemic sclerosisWorse survivalClinical indicationsImpaired left ventricular global longitudinal strainLeft ventricular global longitudinal strainPresence of LGECMR strainLV cardiac indexWorse LV-GLSLV ejection fractionCox regression analysisGlobal longitudinal strainLV cardiac outputGlobal radialCardiac indexOverall survivalRetrospective cohortEjection fractionPrognostic valueAdverse outcomesCardiac outputGadolinium enhancementRV strain
2021
Cardiovascular safety profile of taxanes and vinca alkaloids: 30 years FDA registry experience
Batra A, Patel B, Addison D, Baldassarre LA, Desai N, Weintraub N, Deswal A, Hussain Z, Brown SA, Ganatra S, Agarwala V, Parikh PM, Fradley M, Ghosh A, Guha A. Cardiovascular safety profile of taxanes and vinca alkaloids: 30 years FDA registry experience. Open Heart 2021, 8: e001849. PMID: 34952868, PMCID: PMC8710909, DOI: 10.1136/openhrt-2021-001849.Peer-Reviewed Original ResearchConceptsCardiovascular adverse eventsAdverse Event Reporting SystemCombination therapyAntimicrotubular agentsVinca alkaloidsAdverse eventsDrug Administration Adverse Event Reporting SystemRoutine cardiovascular assessmentCardiovascular safety profilePolytomous logistic regressionEvent Reporting SystemAgent therapyCombination chemotherapyHeart failureRegistry experienceSafety profileCardiovascular assessmentHigh burdenInhibitor combinationsChemotherapeutic agentsTaxanesTherapyLogistic regressionMonotherapyReporting systemLeft ventricular myocardial strain and tissue characterization by cardiac magnetic resonance imaging in immune checkpoint inhibitor associated cardiotoxicity
Higgins AY, Arbune A, Soufer A, Ragheb E, Kwan JM, Lamy J, Henry M, Cuomo JR, Charifa A, Gallegos C, Hull S, Coviello JS, Bader AS, Peters DC, Huber S, Mojibian HR, Sinusas AJ, Kluger H, Baldassarre LA. Left ventricular myocardial strain and tissue characterization by cardiac magnetic resonance imaging in immune checkpoint inhibitor associated cardiotoxicity. PLOS ONE 2021, 16: e0246764. PMID: 33606757, PMCID: PMC7895343, DOI: 10.1371/journal.pone.0246764.Peer-Reviewed Original ResearchConceptsGlobal longitudinal strainImmune checkpoint inhibitorsLate gadolinium enhancementRecovery of LVEFLake Louise criteriaCheckpoint inhibitorsNormal LVEFAverage global longitudinal strainPresence of LGEAbnormal global longitudinal strainCardiac magnetic resonance imagingCorrect clinical contextEvaluation of myocarditisLeft ventricular dysfunctionVentricular ejection fractionDiagnosis of myocarditisLeft ventricular strainCardiac magnetic resonanceLeft ventricular myocardial strainOvert left ventricular dysfunctionVentricular myocardial strainMagnetic resonance imagingAtrial strainVentricular dysfunctionVentricular strain
2020
Cardiovascular disease in women: insights from magnetic resonance imaging
Bucciarelli-Ducci C, Ostenfeld E, Baldassarre LA, Ferreira VM, Frank L, Kallianos K, Raman SV, Srichai MB, McAlindon E, Mavrogeni S, Ntusi NAB, Schulz-Menger J, Valente AM, Ordovas KG. Cardiovascular disease in women: insights from magnetic resonance imaging. Journal Of Cardiovascular Magnetic Resonance 2020, 22: 71. PMID: 32981527, PMCID: PMC7520984, DOI: 10.1186/s12968-020-00666-4.Peer-Reviewed Original ResearchConceptsCardiovascular magnetic resonanceCardiovascular diseaseValue of CMRRole of CMRPulmonary arterial hypertensionUnique diagnostic challengeConnective tissue disordersMagnetic resonance imagingArterial hypertensionPeripartum cardiomyopathyUnderrecognized conditionCardiovascular differencesPrognostic roleFemale patientsPatient populationDiagnostic challengeTissue disordersCardiovascular disordersResonance imagingClinical mismanagementDiseaseImaging modalitiesWomenSex differencesFurther investigation
2019
Left atrial fibrosis correlates with extent of left ventricular myocardial delayed enhancement and left ventricular strain in hypertrophic cardiomyopathy
Latif SR, Nguyen VQ, Peters DC, Soufer A, Henry ML, Grunseich K, Testani J, Hur DJ, Huber S, Mojibian H, Dicks D, Sinusas AJ, Meadows JL, Papoutsidakis N, Jacoby D, Baldassarre LA. Left atrial fibrosis correlates with extent of left ventricular myocardial delayed enhancement and left ventricular strain in hypertrophic cardiomyopathy. The International Journal Of Cardiovascular Imaging 2019, 35: 1309-1318. PMID: 30790116, DOI: 10.1007/s10554-019-01551-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAngiotensin Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsAtrial Function, LeftAtrial RemodelingCardiomyopathy, HypertrophicContrast MediaFemaleFibrosisHeart AtriaHeart VentriclesHumansHypertrophy, Left VentricularMagnetic Resonance Imaging, CineMaleMiddle AgedOrganometallic CompoundsPredictive Value of TestsRetrospective StudiesVentricular Dysfunction, LeftVentricular Function, LeftVentricular RemodelingConceptsLA fibrosisLV-LGEHypertrophic cardiomyopathyLA-LGELV fibrosisLV parametersLV end-diastolic volumeSetting of HCMAldosterone system inhibitionLate gadolinium enhancement (LGE) sequencesLV global strainLeft ventricular massEnd-diastolic volumeLeft atrial fibrosisMaximum wall thicknessFibrosis correlatesRenin-AngiotensinVentricular strainMedication usageAtrial fibrosisLV remodelingVentricular massLV massSystem inhibitionDiastolic volume
2018
REPAIRit: Improving Myocardial Nulling and Ghosting Artifacts of 3D Navigator‐Gated Late Gadolinium Enhancement Imaging During Arrhythmia
Hu C, Huber S, Latif SR, Santacana‐Laffitte G, Mojibian HR, Baldassarre LA, Peters DC. REPAIRit: Improving Myocardial Nulling and Ghosting Artifacts of 3D Navigator‐Gated Late Gadolinium Enhancement Imaging During Arrhythmia. Journal Of Magnetic Resonance Imaging 2018, 49: 688-699. PMID: 30252987, DOI: 10.1002/jmri.26284.Peer-Reviewed Original ResearchAssessment of diastolic function and atrial remodeling by MRI – validation and correlation with echocardiography and filling pressure
Seemann F, Baldassarre LA, Llanos‐Chea F, Gonzales RA, Grunseich K, Hu C, Sugeng L, Meadows J, Heiberg E, Peters DC. Assessment of diastolic function and atrial remodeling by MRI – validation and correlation with echocardiography and filling pressure. Physiological Reports 2018, 6: e13828. PMID: 30187654, PMCID: PMC6125607, DOI: 10.14814/phy2.13828.Peer-Reviewed Original ResearchConceptsLate gadolinium enhancementMagnetic resonance imagingPulmonary capillary wedge pressureLA late gadolinium enhancementCapillary wedge pressureTransthoracic echocardiographyDiastolic functionDiastolic parametersWedge pressureAtrial remodelingFilling pressureCardiovascular magnetic resonance imagingLeft atrial remodelingVentricular filling pressureAtrial late gadolinium enhancementLGE-magnetic resonance imagingDiastolic dysfunctionMedical chartsLA volumeAtrial fibrosisGadolinium enhancementResonance imagingPressure catheterizationLow interobserverEchocardiography
2017
Diagnosis of extensive myocardial infiltration by diffuse large B-cell lymphoma using 18F-fluorodeoxyglucose positron emission tomography (18-FDG PET)
Higgins AY, Taylor EP, Baldassarre LA, Miller EJ, Rosenfeld LE. Diagnosis of extensive myocardial infiltration by diffuse large B-cell lymphoma using 18F-fluorodeoxyglucose positron emission tomography (18-FDG PET). Journal Of Nuclear Cardiology 2017, 25: 1869-1871. PMID: 29116563, DOI: 10.1007/s12350-017-1099-1.Peer-Reviewed Case Reports and Technical NotesReverse double inversion‐recovery: Improving motion robustness of cardiac T2‐weighted dark‐blood turbo spin‐echo sequence
Hu C, Huber S, Latif SR, Santacana‐Laffitte G, Mojibian HR, Baldassarre LA, Peters DC. Reverse double inversion‐recovery: Improving motion robustness of cardiac T2‐weighted dark‐blood turbo spin‐echo sequence. Journal Of Magnetic Resonance Imaging 2017, 47: 1498-1508. PMID: 29112315, PMCID: PMC6346424, DOI: 10.1002/jmri.25886.Peer-Reviewed Original ResearchAdultAgedAlgorithmsArtifactsComputer SimulationDiastoleFemaleHealthy VolunteersHeartHeart DiseasesHeart VentriclesHumansImage EnhancementImage Interpretation, Computer-AssistedImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedMotionMyocardiumProspective StudiesQuality ControlReproducibility of ResultsSignal-To-Noise Ratio
2013
Mitral Apparatus Assessment by Delayed Enhancement CMR Relative Impact of Infarct Distribution on Mitral Regurgitation
Chinitz JS, Chen D, Goyal P, Wilson S, Islam F, Nguyen T, Wang Y, Hurtado-Rua S, Simprini L, Cham M, Levine RA, Devereux RB, Weinsaft JW. Mitral Apparatus Assessment by Delayed Enhancement CMR Relative Impact of Infarct Distribution on Mitral Regurgitation. JACC Cardiovascular Imaging 2013, 6: 220-234. PMID: 23489536, PMCID: PMC4048744, DOI: 10.1016/j.jcmg.2012.08.016.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnterior Wall Myocardial InfarctionChi-Square DistributionContrast MediaEchocardiography, Doppler, ColorEchocardiography, Doppler, PulsedFemaleHumansInferior Wall Myocardial InfarctionLogistic ModelsMagnetic Resonance Imaging, CineMaleMiddle AgedMitral ValveMitral Valve InsufficiencyMultivariate AnalysisMyocardiumOdds RatioPapillary MusclesPredictive Value of TestsProspective StudiesRegistriesRisk AssessmentRisk FactorsTime FactorsConceptsPapillary muscle infarctionAcute myocardial infarctionDelayed-enhancement cardiac magnetic resonanceMitral regurgitationInfarct distributionCulprit vesselMuscle infarctionPapillary musclesLateral wall infarctionLV end-diastolic diameterFirst acute myocardial infarctionGreater mitral regurgitationEnd-diastolic diameterCardiac magnetic resonanceMitral annular diameterLeft ventricular wallRight coronaryLeft circumflexInfarct patternsMultivariable analysisInfarct sizeMyocardial infarctionBasis of presenceWall injuryLV size