2024
Impact of early intervention on health status outcomes in peripheral artery disease patients with chronic total occlusion lesions using the PORTRAIT registry
Cerrud-Rodriguez R, Romain G, Hussain Y, Cleman J, Callegari S, Scierka L, Smolderen K, Mena-Hurtado C. Impact of early intervention on health status outcomes in peripheral artery disease patients with chronic total occlusion lesions using the PORTRAIT registry. Journal Of Vascular Surgery 2024, 80: 780-790.e10. PMID: 38735596, DOI: 10.1016/j.jvs.2024.04.061.Peer-Reviewed Original ResearchPeripheral Artery QuestionnairePeripheral arterial diseaseHealth statusChronic total occlusionChronic total occlusion lesionsPAD-specific health statusEarly invasive treatmentMultilevel generalized linear regression modelsPeripheral arterial disease symptomsLower extremity peripheral arterial diseaseBaseline health statusHealth status outcomesInvasive treatmentHealth status trajectoriesNon-invasive treatmentPatients' health statusImpact of early interventionHigh health statusFollow-upPeripheral arterial disease patientsSymptomatic peripheral arterial diseaseMonths of follow-upPresence of chronic total occlusionNon-invasive treatment strategyStatus outcomesASSOCIATION BETWEEN DEPRESSIVE SYMPTOMS AND HEALTH STATUS OUTCOMES IN PATIENTS WITH SYMPTOMATIC PERIPHERAL ARTERY DISEASE
Jacque F, Romain G, Peri-Okonny P, Sinusas A, Callegari S, Cleman J, Scierka L, Mares A, Hurtado C, Smolderen K. ASSOCIATION BETWEEN DEPRESSIVE SYMPTOMS AND HEALTH STATUS OUTCOMES IN PATIENTS WITH SYMPTOMATIC PERIPHERAL ARTERY DISEASE. Journal Of The American College Of Cardiology 2024, 83: 2308. DOI: 10.1016/s0735-1097(24)04298-0.Peer-Reviewed Original Research
2022
One-Year Health Status Outcomes Following Early Invasive and Noninvasive Treatment in Symptomatic Peripheral Artery Disease
Angraal S, Hejjaji V, Tang Y, Gosch KL, Patel MR, Heyligers J, White CJ, Nolthenius R, Mena-Hurtado C, Aronow HD, Moneta GL, Fitridge R, Soukas PA, Abbott JD, Secemsky EA, Spertus JA, Smolderen KG. One-Year Health Status Outcomes Following Early Invasive and Noninvasive Treatment in Symptomatic Peripheral Artery Disease. Circulation Cardiovascular Interventions 2022, 15: e011506. PMID: 35579010, PMCID: PMC11299756, DOI: 10.1161/circinterventions.121.011506.Peer-Reviewed Original ResearchConceptsHealth status outcomesPropensity-matched sampleEarly invasiveHealth statusEarly revascularizationStatus outcomesSymptomatic peripheral artery diseaseDisease-specific health statusNoninvasive management strategiesPeripheral Artery QuestionnaireTreatment-resistant symptomsEarly invasive managementPeripheral artery diseaseBaseline health statusEarly invasive treatmentHealth status trajectoriesHealth status improvementReal-world evidencePORTRAIT registryArtery diseaseInvasive managementNoninvasive managementPatient preferencesInvasive treatmentLifestyle changesThe shifting care and outcomes for patients with endangered limbs – Critical limb ischemia (SCOPE-CLI) registry overview of study design and rationale
Scierka LE, Mena-Hurtado C, Shishehbor MH, Spertus JA, Nagpal S, Babrowski T, Bunte MC, Politano A, Humphries M, Chung J, Kirksey L, Alabi O, Soukas P, Parikh S, Faizer R, Fitridge R, Provance J, Romain G, McMillan N, Stone N, Scott K, Fuss C, Pacheco CM, Gosch K, Harper-Brooks A, Smolderen KG, Consortium O. The shifting care and outcomes for patients with endangered limbs – Critical limb ischemia (SCOPE-CLI) registry overview of study design and rationale. IJC Heart & Vasculature 2022, 39: 100971. PMID: 35198727, PMCID: PMC8850321, DOI: 10.1016/j.ijcha.2022.100971.Peer-Reviewed Original ResearchCritical limb ischemiaTreatment preferencesPeripheral artery diseaseProspective observational registryPatient-centered outcomesPatterns of carePoor wound healingHealth status outcomesProcess of careCLI careObservational registryLimb ischemiaPatient characteristicsArtery diseaseVascular centersVital statusMean agePatient preferencesPatient's perspectiveSevere formPatientsPsychosocial factorsStatus outcomesHealth statusCare experiences
2021
Association of sleep apnea with outcomes in peripheral artery disease: Insights from the PORTRAIT study
Jelani QU, Mena-Hurtado C, Gosch K, Mohammed M, Labrosciano C, Regan C, Scierka LE, Spertus JA, Nagpal S, Smolderen KG. Association of sleep apnea with outcomes in peripheral artery disease: Insights from the PORTRAIT study. PLOS ONE 2021, 16: e0256933. PMID: 34506511, PMCID: PMC8432750, DOI: 10.1371/journal.pone.0256933.Peer-Reviewed Original ResearchConceptsPeripheral artery diseasePeripheral Artery QuestionnaireSleep apneaHealth statusArtery diseaseSummary scoresDisease-specific Peripheral Artery QuestionnaireFive-year survival curvesHigh ankle-brachial indexPAQ summary scoreVascular specialty clinicsAnkle-brachial indexLog-rank testSleep apnea statusHealth status outcomesWorse health statusQuality of lifeBetter health statusCause mortalityMultivariable adjustmentPAD symptomsCoronary diseasePeripheral interventionsUS patientsMean age
2020
Association of perceived stress with health status outcomes in patients with peripheral artery disease
Malik AO, Peri-Okonny P, Gosch K, Thomas MB, Mena-Hurtado C, Hiatt W, Aronow HD, Jones PG, Provance J, Labrosciano C, Jelani QU, Spertus JA, Smolderen KG. Association of perceived stress with health status outcomes in patients with peripheral artery disease. Journal Of Psychosomatic Research 2020, 140: 110313. PMID: 33279876, PMCID: PMC8130536, DOI: 10.1016/j.jpsychores.2020.110313.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseHealth status outcomesArtery diseaseStatus outcomesSelf-perceived stressSummary scoresDisease-specific health statusPoor recoveryHigh chronic stressProspective registryChart reviewAnalytical cohortMean ageAverage stress scoreHealth statusDisease severityPatientsChronic stressComorbiditiesSum scoreAverage exposureDiseaseStress scoresSocioeconomic statusTime pointsAssociation of Diabetes Mellitus With Health Status Outcomes in Patients With Peripheral Artery Disease: Insights From the PORTRAIT Registry
Patel KK, Alturkmani H, Gosch K, Mena‐Hurtado C, Shishehbor MH, Peri‐Okonny P, Creager MA, Spertus JA, Smolderen KG. Association of Diabetes Mellitus With Health Status Outcomes in Patients With Peripheral Artery Disease: Insights From the PORTRAIT Registry. Journal Of The American Heart Association 2020, 9: e017103. PMID: 33153398, PMCID: PMC7763706, DOI: 10.1161/jaha.120.017103.Peer-Reviewed Original ResearchConceptsPeripheral artery diseasePAQ summary scoreDiabetes mellitusHealth statusArtery diseaseSummary scoresEffect of DMInteraction of DMPAD-specific health statusSymptomatic peripheral artery diseaseAdverse limb eventsHealth status benefitsBaseline health statusHealth status outcomesPoor health statusHealth status gainsComorbidity burdenPAD progressionPAD severityPORTRAIT registryBackground PatientsConclusions PatientsInternational registryRecent exacerbationSpecialty clinicRelationship Between Depressive Symptoms and Health Status in Peripheral Artery Disease: Role of Sex Differences
Jelani Q, Mena‐Hurtado C, Burg M, Soufer R, Gosch K, Jones PG, Spertus JA, Safdar B, Smolderen KG. Relationship Between Depressive Symptoms and Health Status in Peripheral Artery Disease: Role of Sex Differences. Journal Of The American Heart Association 2020, 9: e014583. PMID: 32781883, PMCID: PMC7660812, DOI: 10.1161/jaha.119.014583.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseDepressive symptomsHealth statusArtery diseaseEQ-5D visual analog scale scoresEQ-5D visual analog scaleVisual analog scale scoreGeneric health statusPeripheral Artery QuestionnaireVascular specialty clinicsAnalog scale scoreHealth status scoresPatient Health QuestionnaireSevere depressive symptomsVisual analog scaleHealth status outcomesWorse health statusAdjusted general linear modelSex differencesPORTRAIT registryPAD diagnosisPAD symptomsAnalog scaleConclusions WomenMean agePatient profiles and health status outcomes for peripheral artery disease in high-income countries: a comparison between the USA and The Netherlands
Jelani QU, Smolderen KG, Halpin D, Gosch K, Spertus JA, Chaar C, Nolthenius R, Heyligers J, De Vries JP, Mena-Hurtado C. Patient profiles and health status outcomes for peripheral artery disease in high-income countries: a comparison between the USA and The Netherlands. European Heart Journal - Quality Of Care And Clinical Outcomes 2020, 7: 505-512. PMID: 32539108, DOI: 10.1093/ehjqcco/qcaa052.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseHealth status scoresHealth status outcomesStatus scoreStatus outcomesArtery diseaseUS patientsHigh-income countriesPatient profilesCardiovascular risk factor burdenPAD-specific health statusPeripheral Artery QuestionnaireRisk factor burdenVascular specialty clinicsPeripheral arterial diseasePatient-centered outcomesLow referral ratesMore financial barriersPAD carePAD outcomesNew onsetPAD symptomsArterial diseaseExercise treatmentReferral rates
2019
Financial barriers in accessing medical care for peripheral artery disease are associated with delay of presentation and adverse health status outcomes in the United States
Jelani QU, Jhamnani S, Spatz ES, Spertus J, Smolderen KG, Wang J, Desai NR, Jones P, Gosch K, Shah S, Attaran R, Mena-Hurtado C. Financial barriers in accessing medical care for peripheral artery disease are associated with delay of presentation and adverse health status outcomes in the United States. Vascular Medicine 2019, 25: 13-24. PMID: 31603393, DOI: 10.1177/1358863x19872542.Peer-Reviewed Original ResearchMeSH KeywordsAgedFemaleHealth Care CostsHealth Services AccessibilityHealth Status DisparitiesHealthcare DisparitiesHumansInsurance, HealthMaleMedically UninsuredMiddle AgedPatient Reported Outcome MeasuresPeripheral Arterial DiseaseProspective StudiesQuality of LifeRisk FactorsTime FactorsTime-to-TreatmentUnited StatesConceptsPeripheral artery diseasePeripheral Artery QuestionnaireHealth status outcomesHealth statusArtery diseaseStatus outcomesFinancial barriersGeneral health-related qualityDisease-specific health statusPatient-reported health statusDelay of presentationPatient-reported difficultyVascular specialty clinicsPeripheral arterial diseaseEuroQol-5 DimensionsHealth-related qualityPoor health statusUnited States patientsMulticenter registryMultivariable adjustmentPAD symptomsArterial diseaseTreatment patternsUS patientsLate presentationTHE ASSOCIATION OF PERCEIVED STRESS WITH HEALTH STATUS OUTCOMES IN PATIENTS WITH PERIPHERAL ARTERY DISEASE
Malik A, Peri-Okonny P, Provance J, Gosch K, Thomas M, Labrosciano C, Spertus J, Smolderen K. THE ASSOCIATION OF PERCEIVED STRESS WITH HEALTH STATUS OUTCOMES IN PATIENTS WITH PERIPHERAL ARTERY DISEASE. Journal Of The American College Of Cardiology 2019, 73: 2081. DOI: 10.1016/s0735-1097(19)32687-7.Peer-Reviewed Original Research
2018
PORTRAIT (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease
Smolderen KG, Gosch K, Patel M, Jones WS, Hirsch AT, Beltrame J, Fitridge R, Shishehbor MH, Denollet J, Vriens P, Heyligers J, Stone MEd N, Aronow H, Abbott JD, Labrosciano C, Tutein-Nolthenius R, A Spertus J. PORTRAIT (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease. Circulation Cardiovascular Quality And Outcomes 2018, 11: e003860. PMID: 29440123, DOI: 10.1161/circoutcomes.117.003860.Peer-Reviewed Original ResearchMeSH KeywordsAgedAustraliaCardiovascular AgentsExercise TherapyFemaleHealth StatusHealth Status IndicatorsHealthcare DisparitiesHumansIntermittent ClaudicationLife StyleMaleMiddle AgedMulticenter Studies as TopicNetherlandsPatient Outcome AssessmentPeripheral Arterial DiseaseProspective StudiesQuality of LifeRegistriesResearch DesignRisk FactorsSurveys and QuestionnairesTime FactorsTreatment OutcomeUnited StatesVascular Surgical ProceduresConceptsHealth status outcomesHealth statusMedical historyMedical recordsStatus outcomesAbnormal ankle-brachial indexPAD-related hospitalizationAnkle-brachial indexCardiovascular risk factorsMajor cardiovascular eventsPatients' medical recordsComparative effectiveness studiesHealth status dataPatient's medical historyPatients' health statusQuality of lifeClaudication symptomsEligible patientsCardiovascular eventsPAD symptomsPatient characteristicsClinician adherenceRisk stratificationLifestyle factorsFunctional status
2016
Health Status Outcomes in Patients With Acute Myocardial Infarction After Rehospitalization
Shore S, Smolderen KG, Kennedy KF, Jones PG, Arnold SV, Cohen DJ, Stolker JM, Zhao Z, Wang TY, Ho PM, Spertus JA. Health Status Outcomes in Patients With Acute Myocardial Infarction After Rehospitalization. Circulation Cardiovascular Quality And Outcomes 2016, 9: 777-784. PMID: 27780850, PMCID: PMC5794496, DOI: 10.1161/circoutcomes.116.002883.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngina, UnstableFemaleHealth StatusHealth Status IndicatorsHumansLinear ModelsLogistic ModelsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionMyocardial RevascularizationPatient ReadmissionPredictive Value of TestsPropensity ScoreProspective StudiesQuality of LifeRegistriesRisk FactorsSurveys and QuestionnairesTime FactorsUnited StatesConceptsAcute myocardial infarctionComposite end pointUnplanned revascularizationUnstable anginaMyocardial infarctionHealth statusEuroQol-5D visual analogue scaleVisual analog scale scoreEnd pointUnplanned coronary revascularizationPropensity-matched cohortAnalog scale scoreSeattle Angina QuestionnaireVisual analog scaleHealth status outcomesWorse health statusAngina QuestionnaireCoronary revascularizationRehospitalization ratesAnalog scaleMean ageSuch readmissionsQuestionnaire domainsClinical trialsRehospitalization
2015
One Year Health Status Benefits Following Treatment for New Onset or Exacerbation of Peripheral Arterial Disease Symptoms: The Importance of Patients' Baseline Health Status
van Zitteren M, Denollet J, Heyligers JM, Elshof JW, Nooren MJ, Burger DH, de Fijter WM, Vriens PW, Smolderen KG. One Year Health Status Benefits Following Treatment for New Onset or Exacerbation of Peripheral Arterial Disease Symptoms: The Importance of Patients' Baseline Health Status. European Journal Of Vascular And Endovascular Surgery 2015, 50: 213-222. PMID: 26036809, DOI: 10.1016/j.ejvs.2015.04.003.Peer-Reviewed Original ResearchMeSH KeywordsAgedDisease ProgressionFemaleHealth StatusHealth Status IndicatorsHumansLinear ModelsMaleMental HealthMiddle AgedNetherlandsPeripheral Arterial DiseasePredictive Value of TestsPropensity ScoreProspective StudiesRecovery of FunctionRisk FactorsSeverity of Illness IndexTime FactorsTreatment OutcomeUltrasonography, Doppler, DuplexConceptsHealth status scoresPeripheral arterial diseaseHealth status gainsBaseline health statusInvasive treatmentStatus scoreHealth statusPatient's baseline health statusPeripheral arterial disease symptomsHealth status levelsHealth status outcomesNew onsetPAD symptomsVascular clinicArterial diseaseHighest quartilePCS scoresInvasive strategyTreatment strategiesClinical informationStatus outcomesPatientsLinear regression analysisChange scoresExacerbationGender differences in pre-event health status of young patients with acute myocardial infarction: A VIRGO study analysis
Dreyer RP, Smolderen KG, Strait KM, Beltrame JF, Lichtman JH, Lorenze NP, D’Onofrio G, Bueno H, Krumholz HM, Spertus JA. Gender differences in pre-event health status of young patients with acute myocardial infarction: A VIRGO study analysis. European Heart Journal Acute Cardiovascular Care 2015, 5: 43-54. PMID: 25681487, PMCID: PMC4658311, DOI: 10.1177/2048872615568967.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPrior coronary artery diseaseCoronary artery diseaseHealth statusMyocardial infarctionYounger patientsArtery diseaseCoronary artery disease historyDisease-specific health statusAcute myocardial infarction patientsAggressive symptom controlCornerstone of careWorse physical functionBaseline health statusMedical record abstractionVisual analog scaleHealth status outcomesMyocardial infarction patientsDisease-specific measuresMean health scoresLogistic regression analysisQuality of lifeHealth status informationGender differencesSymptom control
2012
Perceived Stress in Myocardial Infarction Long-Term Mortality and Health Status Outcomes
Arnold SV, Smolderen KG, Buchanan DM, Li Y, Spertus JA. Perceived Stress in Myocardial Infarction Long-Term Mortality and Health Status Outcomes. Journal Of The American College Of Cardiology 2012, 60: 1756-1763. PMID: 23040574, PMCID: PMC3601381, DOI: 10.1016/j.jacc.2012.06.044.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHealth status outcomesChronic stressHealth statusAMI patientsStatus outcomesAdverse long-term outcomesLong-term adverse outcomesEuroQol visual analogue scaleGeneric health statusPost-AMI outcomesSeattle Angina QuestionnaireLong-term mortalityShort Form-12Long-term outcomesVisual analog scaleImportant confounding factorsRecurrent adverse eventsRevascularization statusAngina QuestionnaireAdverse eventsClinical characteristicsClinical factorsForm-12Analog scale
2011
Percutaneous transluminal angioplasty: Association between depressive symptoms and diminished health status benefits
Smolderen KG, Safley DM, House JA, Spertus JA, Marso SP. Percutaneous transluminal angioplasty: Association between depressive symptoms and diminished health status benefits. Vascular Medicine 2011, 16: 260-266. PMID: 21828173, DOI: 10.1177/1358863x11415568.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, BalloonCross-Sectional StudiesDepressionFemaleHealth StatusHumansLinear ModelsMaleMiddle AgedMissouriPatient SatisfactionPeripheral Arterial DiseaseProspective StudiesQuality of LifeRecovery of FunctionRegistriesRisk AssessmentRisk FactorsSeverity of Illness IndexSocial BehaviorSurveys and QuestionnairesTime FactorsTreatment OutcomeConceptsPeripheral artery diseasePeripheral endovascular revascularizationPercutaneous transluminal angioplastyDepressive symptomsHealth statusWorsened depressionHealth status 1 yearDisease-specific health statusHealth status benefitsBaseline depressive symptomsHealth status outcomesEndovascular revascularizationPAD patientsTransluminal angioplastyArtery diseaseDepression statusCardiac diseasePatientsStatus outcomesSymptomsLess improvementDepressionBaselineStatus benefitsDisease