2024
Effect of Stress-Related Neural Pathways on the Cardiovascular Benefit of Physical Activity
Zureigat H, Osborne M, Abohashem S, Mezue K, Gharios C, Grewal S, Cardeiro A, Naddaf N, Civieri G, Abbasi T, Radfar A, Aldosoky W, Seligowski A, Wasfy M, Guseh J, Churchill T, Rosovsky R, Fayad Z, Rosenzweig A, Baggish A, Pitman R, Choi K, Smoller J, Shin L, Tawakol A. Effect of Stress-Related Neural Pathways on the Cardiovascular Benefit of Physical Activity. Journal Of The American College Of Cardiology 2024, 83: 1543-1553. PMID: 38631773, PMCID: PMC11164527, DOI: 10.1016/j.jacc.2024.02.029.Peer-Reviewed Original ResearchConceptsCardiovascular disease eventsPhysical activityCardiovascular diseaseCVD riskBenefits of physical activityMass General Brigham BiobankElectronic health recordsIncident CVD eventsReduce CVD riskDecrease CVDCardiovascular disease riskPA surveyGreater PANeural activityPA benefitsHealth recordsPotential cardiovascular diseaseCVD eventsPreexisting depressionGuideline recommendationsStress-related activationCardiovascular disease benefitMultivariate modelDepressionNeural effects
2023
Reply Causal Pathway of Alcohol Intake: Stress-Related Neuronal Activity and Cardiovascular Risk
Mezue K, Abohashem S, Osborne M, Tawakol A. Reply Causal Pathway of Alcohol Intake: Stress-Related Neuronal Activity and Cardiovascular Risk. Journal Of The American College Of Cardiology 2023, 82: e227-e228. PMID: 38030356, PMCID: PMC10752352, DOI: 10.1016/j.jacc.2023.09.825.Peer-Reviewed Original ResearchReduced Stress-Related Neural Network Activity Mediates the Effect of Alcohol on Cardiovascular Risk
Mezue K, Osborne M, Abohashem S, Zureigat H, Gharios C, Grewal S, Radfar A, Cardeiro A, Abbasi T, Choi K, Fayad Z, Smoller J, Rosovsky R, Shin L, Pitman R, Tawakol A. Reduced Stress-Related Neural Network Activity Mediates the Effect of Alcohol on Cardiovascular Risk. Journal Of The American College Of Cardiology 2023, 81: 2315-2325. PMID: 37316112, PMCID: PMC10333800, DOI: 10.1016/j.jacc.2023.04.015.Peer-Reviewed Original ResearchConceptsNeural network activityAlcohol consumptionMACE riskEffects of alcoholAssociated with lower MACE riskHealth behavior surveyMass General Brigham BiobankNetwork activityBrain networksLower MACE riskChronic stressMedian follow-upLight/moderate alcohol consumptionCardiovascular risk factorsAdverse cardiovascular eventsAssociated with larger decreasesBrain imagingPotential health detrimentCardiovascular eventsFollow-upBehavior SurveyCardiovascular riskRisk factorsCardiovascular diseaseMACEGenetic Variation in Intercellular Adhesion Molecule-1 (ICAM-1) and Diastolic Heart Failure in the Black Population in the United States
Mezue K, Driggin E. Genetic Variation in Intercellular Adhesion Molecule-1 (ICAM-1) and Diastolic Heart Failure in the Black Population in the United States. Journal Of Cardiac Failure 2023, 29: 1173-1174. PMID: 37062471, DOI: 10.1016/j.cardfail.2023.03.021.Peer-Reviewed Original ResearchFocused cardiac ultrasound in pregnancy
Edwards P, Anyaogu C, Mezue K, Baugh D, Goha A, Egbuche O, Nunura F, Madu E. Focused cardiac ultrasound in pregnancy. Journal Of Investigative Medicine 2023, 71: 81-91. PMID: 36691704, DOI: 10.1177/10815589221142195.Peer-Reviewed Original ResearchConceptsFocused cardiac ultrasoundRheumatic heart diseaseCardiac diseaseMaternal morbidityMaternal outcomesMaternal mortality review committeesHeart diseaseAssociated with poor maternal outcomeCause of maternal mortalityCardiac ultrasoundMortality Review CommitteePoor maternal outcomeSymptoms of normal pregnancyMiddle-income countriesExcessive maternal morbidityHigh-income countriesPoint of careAcquired cardiac diseaseManagement of cardiac diseaseMaternal mortalityEmergency medicineDiagnosis of cardiac diseaseNormal pregnancyTreatment of heart diseasePrompt recognition
2022
Fluid Restriction Recommendations in Heart Failure: Dry as a Bone or Quench Your Thirst?
Merlo A, Mezue K, Ambrosy A. Fluid Restriction Recommendations in Heart Failure: Dry as a Bone or Quench Your Thirst? Journal Of Cardiac Failure 2022, 28: 1531-1533. PMID: 35977689, DOI: 10.1016/j.cardfail.2022.07.054.Peer-Reviewed Original ResearchThe combined effect of air and transportation noise pollution on atherosclerotic inflammation and risk of cardiovascular disease events
Osborne M, Abohashem S, Naddaf N, Abbasi T, Zureigat H, Mezue K, Ghoneem A, Dar T, Cardeiro A, Mehta N, Rajagopalan S, Fayad Z, Tawakol A. The combined effect of air and transportation noise pollution on atherosclerotic inflammation and risk of cardiovascular disease events. Journal Of Nuclear Cardiology 2022, 30: 665-679. PMID: 35915324, PMCID: PMC9889575, DOI: 10.1007/s12350-022-03003-7.Peer-Reviewed Original ResearchConceptsAir pollutionNoise exposureAverage air pollutionMajor adverse cardiovascular eventsTransportation noise exposureCardiovascular disease eventsPollutionRisk of cardiovascular disease eventsHigher exposuresDisease eventsIndividual residentsMajor adverse cardiovascular events riskActive cancerCardiovascular diseaseNoise pollutionAssociated with major adverse cardiovascular eventsAdverse cardiovascular eventsExposureF-FDG PET/CT imagingCardiovascular eventsRiskEffect of airAirArterial inflammationYearsPET myocardial perfusion imaging in superior vena cava syndrome
Mezue K, Chow D, Tawakol A, Fakhri G, Osborne M. PET myocardial perfusion imaging in superior vena cava syndrome. Journal Of Nuclear Cardiology 2022, 30: 1720-1724. PMID: 35764777, PMCID: PMC9794631, DOI: 10.1007/s12350-022-03033-1.Peer-Reviewed Original ResearchMolecular Imaging in Acute Aortic Syndrome Lighting a Path to Better Risk Assessment ∗
Tawakol A, Mezue K. Molecular Imaging in Acute Aortic Syndrome Lighting a Path to Better Risk Assessment ∗. JACC Cardiovascular Imaging 2022, 15: 1305-1307. PMID: 35798406, DOI: 10.1016/j.jcmg.2022.04.022.Peer-Reviewed Original Research
2021
Racial differences in cardiopulmonary outcomes of hospitalized COVID-19 patients with acute kidney injury
Egbuche O, Abe T, Nwokike S, Jegede O, Mezue K, Olanipekun T, Onuorah I, Echols M. Racial differences in cardiopulmonary outcomes of hospitalized COVID-19 patients with acute kidney injury. Reviews In Cardiovascular Medicine 2021, 22: 1667-1675. PMID: 34957809, PMCID: PMC9054458, DOI: 10.31083/j.rcm2204174.Peer-Reviewed Original ResearchConceptsIn-hospital cardiac eventsCOVID-19 patientsIn-hospital mortalityCardiac eventsGrady Health SystemNon-blacksAssociated with increased disease burdenCardiopulmonary outcomesPolymerase-chain-reaction assayAssociated with higher riskMortality of hospitalized COVID-19 patientsAcute respiratory distress syndromeAssociated with worse outcomesIn-hospital acute kidney injuryMechanism of injuryOutcomes of hospitalized COVID-19 patientsPresence of AKIHospitalized COVID-19 patientsRespiratory distress syndromeProportion of patientsAcute kidney injuryPrimary composite outcomeRetrospective cohort studyImpact of AKIHealth system
2020
Indigenous people and the COVID-19 pandemic: the tip of an iceberg of social and economic inequities
Goha A, Mezue K, Edwards P, Madu K, Baugh D, Tulloch-Reid E, Nunura F, Doubeni C, Madu E. Indigenous people and the COVID-19 pandemic: the tip of an iceberg of social and economic inequities. Journal Of Epidemiology & Community Health 2020, 75: 207-208. PMID: 33067253, DOI: 10.1136/jech-2020-214755.Peer-Reviewed Original ResearchTransvenous Retrieval of a Pulmonary Artery Catheter Knot Around Pacing Leads: A Case Report
Egbuche O, Nwagbara K, Mezue K, Abe T, Nwokike S. Transvenous Retrieval of a Pulmonary Artery Catheter Knot Around Pacing Leads: A Case Report. Cardiovascular Revascularization Medicine 2020, 28: 144-146. PMID: 33077395, DOI: 10.1016/j.carrev.2020.09.037.Peer-Reviewed Original ResearchConceptsPulmonary artery catheter insertionPulmonary artery catheterInsertion of pulmonary artery cathetersCardiac resynchronization therapyCatheter knottingBlind insertionSevere left ventricular systolic dysfunctionDilated right heart chambersPulmonary artery catheter knottingLeft ventricular systolic dysfunctionManagement of acute heart failureVentricular systolic dysfunctionArtery catheter insertionAcute heart failureRight heart chambersCardiac resynchronization devicesSystolic dysfunctionResynchronization therapyFluoroscopy-guided insertionDilated cardiomyopathyCatheter insertionArtery catheterHeart failureHemodynamic managementResynchronization devicesSub-Saharan Africa Tackles COVID-19: Challenges and Opportunities.
Mezue K, Edwards P, Nsofor I, Goha A, Anya I, Madu K, Baugh D, Nunura F, Gaulton G, Madu E. Sub-Saharan Africa Tackles COVID-19: Challenges and Opportunities. Ethnicity & Disease 2020, 30: 693-694. PMID: 32989369, PMCID: PMC7518544, DOI: 10.18865/ed.30.4.693.Peer-Reviewed Original ResearchCOVID‐19 and the heart: An update for clinicians
Goha A, Mezue K, Edwards P, Nunura F, Baugh D, Madu E. COVID‐19 and the heart: An update for clinicians. Clinical Cardiology 2020, 43: 1216-1222. PMID: 32533585, PMCID: PMC7323229, DOI: 10.1002/clc.23406.Peer-Reviewed Original ResearchConceptsPrognosis of COVID-19 diseaseAdverse cardiac effectsPre-existing cardiovascular diseaseOptimal patient managementAcute myocardial injuryRisk of morbidityAcute coronary syndromeManifestations of COVID-19Cardiovascular manifestations of COVID-19Cardiovascular manifestationsCardiac effectsEffects of medicationVenous thromboembolismCoronary syndromeHeart failureMyocardial injuryPatient managementRAA systemClinical syndromeCardiovascular diseaseViral entrySARS-CoV-2COVID-19 diseaseHeartCOVID-19
2019
Cardiorenal Syndrome: Classification, Pathophysiology, Diagnosis, and Treatment Strategies: A Scientific Statement From the American Heart Association
Rangaswami J, Bhalla V, Blair J, Chang T, Costa S, Lentine K, Lerma E, Mezue K, Molitch M, Mullens W, Ronco C, Tang W, McCullough P, Cardiology O. Cardiorenal Syndrome: Classification, Pathophysiology, Diagnosis, and Treatment Strategies: A Scientific Statement From the American Heart Association. Circulation 2019, 139: e840-e878. PMID: 30852913, DOI: 10.1161/cir.0000000000000664.Peer-Reviewed Original ResearchConceptsCardiorenal syndromeChronic dysfunctionPathogenesis of cardiorenal syndromeHeart-kidney interactionsKidney transplant recipientsSpectrum of disordersTransplant recipientsDiabetes mellitusNeurohormonal markersTreatment strategiesClinical phenotypeFailing heartScientific statementSyndromeClinicopathologic descriptionKidneyMolecular signaturesPatientsDysfunctionCross-talkHeartMellitusPathophysiologyPalliative carePathogenesisEffects of Pulmonary Hypertension and Right Ventricular Function in Short and Long-Term Kidney Function
Naranjo M, Lo K, Mezue K, Rangaswami J. Effects of Pulmonary Hypertension and Right Ventricular Function in Short and Long-Term Kidney Function. Current Cardiology Reviews 2019, 15: 3-11. PMID: 30306876, PMCID: PMC6367698, DOI: 10.2174/1573403x14666181008154215.Peer-Reviewed Original ResearchConceptsEffects of pulmonary hypertensionPulmonary hypertensionKidney transplant outcomesPrognostic implicationsTransplant outcomesPrognostic implications of pulmonary hypertensionRenal diseaseKidney diseaseDefinition of pulmonary hypertensionRight ventricular functionProgression of kidney diseaseAcute kidney injuryProgression of CKDPost-LVAD implantationVentricular functionKidney injuryHemodynamic dysfunctionKidney functionTreatment strategiesHemodynamic effectsHypertensionPatho-physiological effectsInfluence treatmentLVAD implantationMultiple body systems
2018
Response to Letter to the Editor concerning manuscript, “Blood pressure variability predicts adverse events and cardiovascular outcomes in sprint”
Mezue K, Goyal A, Pressman G, Matthew R, Horrow J, Rangaswami J. Response to Letter to the Editor concerning manuscript, “Blood pressure variability predicts adverse events and cardiovascular outcomes in sprint”. Journal Of Clinical Hypertension 2018, 20: 1646-1647. PMID: 30328256, PMCID: PMC8030952, DOI: 10.1111/jch.13400.Peer-Reviewed Original ResearchBlood pressure variability predicts adverse events and cardiovascular outcomes in SPRINT
Mezue K, Goyal A, Pressman G, Matthew R, Horrow J, Rangaswami J. Blood pressure variability predicts adverse events and cardiovascular outcomes in SPRINT. Journal Of Clinical Hypertension 2018, 20: 1247-1252. PMID: 29984884, PMCID: PMC8031192, DOI: 10.1111/jch.13346.Peer-Reviewed Original ResearchConceptsAdverse eventsDiastolic BPCardiovascular outcomesDiastolic BP-CVSystolic BPAntihypertensive therapyTreatment armsRate of treatment-related adverse eventsPrimary outcomeTreatment-related adverse eventsBlood pressureEffects of antihypertensive therapyCox proportional hazards regressionAcute kidney injuryCompare treatment armsPredictors of outcomeVisit-to-visitStudent's t-testTarget systolic BPProportional hazards regressionBlood pressure variabilityLevels of BPSPRINT dataVisit-to-visit DBP variabilityIndependent predictorsBlood stream infection is associated with cerebrovascular accident in patients with left ventricular assist device: a systematic review and meta-analysis
Kanjanahattakij N, Horn B, Abdulhadi B, Wongjarupong N, Mezue K, Rattanawong P. Blood stream infection is associated with cerebrovascular accident in patients with left ventricular assist device: a systematic review and meta-analysis. Journal Of Artificial Organs 2018, 21: 271-277. PMID: 29546615, DOI: 10.1007/s10047-018-1034-5.Peer-Reviewed Original ResearchConceptsBlood stream infectionsLeft ventricular assist deviceIschemic cerebrovascular accidentCerebrovascular accidentPost-left ventricular assist deviceMeta-analysisAssociated with cerebrovascular accidentsVentricular assist deviceStudy assessed patientsEMBASE electronic databasesHemorrhagic cerebrovascular accidentPooled effect sizeRandom-effects modelInverse of varianceHeart failureIncreased incidenceAssist devicePatientsElectronic databasesSystematic reviewEffect sizeMinimal heterogeneityInfectionBloodMultiple studies
2017
Acute kidney injury post–transcatheter aortic valve replacement
Ram P, Mezue K, Pressman G, Rangaswami J. Acute kidney injury post–transcatheter aortic valve replacement. Clinical Cardiology 2017, 40: 1357-1362. PMID: 29251358, PMCID: PMC6490570, DOI: 10.1002/clc.22820.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAcute kidney injuryImpact of acute kidney injuryIntermediate-risk patientsPatient outcomesAortic valve replacementSevere aortic stenosisHigh-risk patientsCost of hospital stayReduce procedural complicationsPeriprocedural hydrationSurgical candidatesValve replacementAortic stenosisImprove patient outcomesBlood transfusionHemodynamic instabilityProcedural complicationsHospital stayKidney injuryPeriprocedural embolizationTreatment optionsDevice implantationPrevent embolizationContrast medium