2024
Anxiety and depression are associated with heightened risk of incident deep vein thrombosis: Mediation through stress‐related neural mechanisms
Rosovsky R, Mezue K, Gharios C, Civieri G, Cardeiro A, Zureigat H, Lau H, Pitman R, Shin L, Abohashem S, Osborne M, Jaffer F, Tawakol A. Anxiety and depression are associated with heightened risk of incident deep vein thrombosis: Mediation through stress‐related neural mechanisms. American Journal Of Hematology 2024, 99: 1927-1938. PMID: 38965839, PMCID: PMC11502251, DOI: 10.1002/ajh.27427.Peer-Reviewed Original ResearchTreatment of anxietyAssociated with heightened riskDeep vein thrombosisNeural mechanismsHeart rate variabilityAutonomic system activityMediation analysisVein thrombosisHs-CRPNeural activityAnxietyDepressionCortical activityIncident deep vein thrombosisF-FDG PET/CT imagingHigh-sensitivity C-reactive proteinFemale participantsMedian follow-upC-reactive proteinDVT risk factorsMedian ageMass General Brigham BiobankRetrospective studyChronic inflammationFollow-up
2021
Anxiety and depression associate with heightened risk of deep venous thrombosis: mediation through neural pathways
Mezue K, Osborne M, Abohashem S, Zureigat H, Abbasi T, Gharios C, Cardeiro A, Akuffo E, Pitman R, Shin L, Jaffer F, Rosovsky R, Tawakol A. Anxiety and depression associate with heightened risk of deep venous thrombosis: mediation through neural pathways. European Heart Journal 2021, 42: ehab724.2045. DOI: 10.1093/eurheartj/ehab724.2045.Peer-Reviewed Original ResearchAnxiety disordersInternational Classification of DiseasesRisk of deep venous thrombosisDeep venous thrombosisNeural activityNeural pathwaysFollow-up periodMass General Brigham BiobankIncreased riskClassification of DiseasesBiobank enrollmentVenous thrombosisIncreased risk of DVTCancer historyIncreased risk of deep venous thrombosisHealth informationMediation analysisDeep venous thrombosis riskInternational ClassificationMedian follow-up periodPotential confoundersAnxietyLower extremity deep venous thrombosisExtremity deep venous thrombosisDepression