2021
Racial differences in cardiopulmonary outcomes of hospitalized COVID-19 patients with acute kidney injury
Egbuche O, Abe T, Nwokike S, Jegede O, Mezue K, Olanipekun T, Onuorah I, Echols M. Racial differences in cardiopulmonary outcomes of hospitalized COVID-19 patients with acute kidney injury. Reviews In Cardiovascular Medicine 2021, 22: 1667-1675. PMID: 34957809, PMCID: PMC9054458, DOI: 10.31083/j.rcm2204174.Peer-Reviewed Original ResearchConceptsIn-hospital cardiac eventsCOVID-19 patientsIn-hospital mortalityCardiac eventsGrady Health SystemNon-blacksAssociated with increased disease burdenCardiopulmonary outcomesPolymerase-chain-reaction assayAssociated with higher riskMortality of hospitalized COVID-19 patientsAcute respiratory distress syndromeAssociated with worse outcomesIn-hospital acute kidney injuryMechanism of injuryOutcomes of hospitalized COVID-19 patientsPresence of AKIHospitalized COVID-19 patientsRespiratory distress syndromeProportion of patientsAcute kidney injuryPrimary composite outcomeRetrospective cohort studyImpact of AKIHealth systemPRE-EXISTING CARDIOVASCULAR DISEASE, ACUTE KIDNEY INJURY, AND CARDIOVASCULAR OUTCOMES IN HOSPITALIZED BLACKS WITH COVID-19 INFECTION
Egbuche O, Jegede O, Abe T, Wagle B, Huynh K, Hayes D, Campbell M, Mezue K, Ram P, Desai R, Kpodonu J, Morgan J, Ofili E, Onwuanyi A, Echols M. PRE-EXISTING CARDIOVASCULAR DISEASE, ACUTE KIDNEY INJURY, AND CARDIOVASCULAR OUTCOMES IN HOSPITALIZED BLACKS WITH COVID-19 INFECTION. Journal Of The American College Of Cardiology 2021, 77: 3081. PMCID: PMC8091265, DOI: 10.1016/s0735-1097(21)04436-3.Peer-Reviewed Original ResearchPre-existing cardiovascular diseaseAcute kidney injuryPre-existing cardiovascular disease, acute kidney injury, and cardiovascular outcomes in hospitalized blacks with COVID-19 infection.
Egbuche O, Jegede O, Abe T, Wagle B, Huynh K, Hayes D, Campbell M, Mezue K, Ram P, Nwokike S, Desai R, Effoe V, Kpodonu J, Morgan J, Ofili E, Onwuanyi A, Echols M. Pre-existing cardiovascular disease, acute kidney injury, and cardiovascular outcomes in hospitalized blacks with COVID-19 infection. Am J Cardiovasc Dis 2021, 11: 212-221. PMID: 34084656, PMCID: PMC8166582.Peer-Reviewed Original ResearchIn-hospital cardiac eventsPre-existing cardiovascular diseaseAcute kidney injuryIn-hospital mortalityAcute respiratory distress syndromeAssociated with increased oddsCardiac eventsCOVID-19 patientsKidney injuryPresence of acute kidney injuryAssociated with increased odds of in-hospital mortalityPolymerase-chain-reaction assayHigher risk of in-hospital mortalityIn-hospital acute kidney injuryAssociated with worse outcomesRisk of in-hospital mortalityCardiovascular diseaseHospitalized COVID-19 patientsRespiratory distress syndromeOdds of in-hospital mortalityAssociated with higher riskRetrospective cohort studyMortality of COVID-19 patientsIn-hospital mortality of COVID-19 patientsDistress syndrome
2019
Effects of Pulmonary Hypertension and Right Ventricular Function in Short and Long-Term Kidney Function
Naranjo M, Lo K, Mezue K, Rangaswami J. Effects of Pulmonary Hypertension and Right Ventricular Function in Short and Long-Term Kidney Function. Current Cardiology Reviews 2019, 15: 3-11. PMID: 30306876, PMCID: PMC6367698, DOI: 10.2174/1573403x14666181008154215.Peer-Reviewed Original ResearchConceptsEffects of pulmonary hypertensionPulmonary hypertensionKidney transplant outcomesPrognostic implicationsTransplant outcomesPrognostic implications of pulmonary hypertensionRenal diseaseKidney diseaseDefinition of pulmonary hypertensionRight ventricular functionProgression of kidney diseaseAcute kidney injuryProgression of CKDPost-LVAD implantationVentricular functionKidney injuryHemodynamic dysfunctionKidney functionTreatment strategiesHemodynamic effectsHypertensionPatho-physiological effectsInfluence treatmentLVAD implantationMultiple body systems
2018
Blood pressure variability predicts adverse events and cardiovascular outcomes in SPRINT
Mezue K, Goyal A, Pressman G, Matthew R, Horrow J, Rangaswami J. Blood pressure variability predicts adverse events and cardiovascular outcomes in SPRINT. Journal Of Clinical Hypertension 2018, 20: 1247-1252. PMID: 29984884, PMCID: PMC8031192, DOI: 10.1111/jch.13346.Peer-Reviewed Original ResearchConceptsAdverse eventsDiastolic BPCardiovascular outcomesDiastolic BP-CVSystolic BPAntihypertensive therapyTreatment armsRate of treatment-related adverse eventsPrimary outcomeTreatment-related adverse eventsBlood pressureEffects of antihypertensive therapyCox proportional hazards regressionAcute kidney injuryCompare treatment armsPredictors of outcomeVisit-to-visitStudent's t-testTarget systolic BPProportional hazards regressionBlood pressure variabilityLevels of BPSPRINT dataVisit-to-visit DBP variabilityIndependent predictors
2017
Acute kidney injury post–transcatheter aortic valve replacement
Ram P, Mezue K, Pressman G, Rangaswami J. Acute kidney injury post–transcatheter aortic valve replacement. Clinical Cardiology 2017, 40: 1357-1362. PMID: 29251358, PMCID: PMC6490570, DOI: 10.1002/clc.22820.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAcute kidney injuryImpact of acute kidney injuryIntermediate-risk patientsPatient outcomesAortic valve replacementSevere aortic stenosisHigh-risk patientsCost of hospital stayReduce procedural complicationsPeriprocedural hydrationSurgical candidatesValve replacementAortic stenosisImprove patient outcomesBlood transfusionHemodynamic instabilityProcedural complicationsHospital stayKidney injuryPeriprocedural embolizationTreatment optionsDevice implantationPrevent embolizationContrast mediumBlood Pressure Variability Predicts Adverse Events and Cardiovascular Outcomes in Chronic Kidney Disease: A Post-Hoc Analysis of the SPRINT Trial
Mezue K, Goyal A, Pressman G, Horrow J, Rangaswami J. Blood Pressure Variability Predicts Adverse Events and Cardiovascular Outcomes in Chronic Kidney Disease: A Post-Hoc Analysis of the SPRINT Trial. American Journal Of Hypertension 2017, 31: 48-52. PMID: 28985328, DOI: 10.1093/ajh/hpx128.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseAcute kidney injuryDiastolic blood pressureDBP CVVisit-to-visitCardiovascular outcomesBlood pressure variabilityAdverse eventsPrimary outcomeKidney diseaseBlood pressureAssociated with adverse cardiovascular outcomesVisit-to-visit blood pressure variabilityCox proportional hazards regressionTarget systolic blood pressureAdverse cardiovascular outcomesPressure variabilityProportional hazards regressionSystolic blood pressurePredicting adverse eventsPost hoc analysisVisit-to-visit DBP variabilityAntihypertensive therapyIndependent predictorsKidney injury