2020
The Foundational Role of Cardiovascular Imaging in the Characterization of Mental Stress–Induced Myocardial Ischemia in Patients with Coronary Artery Disease
Meadows JL, Shah S, Burg MM, Pfau S, Soufer R. The Foundational Role of Cardiovascular Imaging in the Characterization of Mental Stress–Induced Myocardial Ischemia in Patients with Coronary Artery Disease. Current Cardiology Reports 2020, 22: 162. PMID: 33037938, DOI: 10.1007/s11886-020-01407-w.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsActivities of Daily LivingCoronary Artery DiseaseExercise TestHumansMyocardial IschemiaMyocardial Perfusion ImagingConceptsCoronary artery diseaseArtery diseaseMyocardial ischemiaMental Stress–Induced Myocardial IschemiaNon-obstructive coronary artery diseaseStable coronary artery diseaseHalf of patientsEpicardial coronary stenosisMental stress testingMyocardial oxygen demandUnderstanding of pathophysiologyCoronary macroAnginal symptomsCardiac eventsAdverse prognosisEarly mortalityIschemic phenomenaCoronary perfusionCoronary stenosisCoronary microvasculatureInvasive studiesClinical careMyocardial perfusionStress-mediated changesCardiac responseEffects of Psychological Stress on Vascular Physiology: Beyond the Current Imaging Signal
Shah SM, Meadows JL, Burg MM, Pfau S, Soufer R. Effects of Psychological Stress on Vascular Physiology: Beyond the Current Imaging Signal. Current Cardiology Reports 2020, 22: 156. PMID: 33037500, DOI: 10.1007/s11886-020-01406-x.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsCardiovascular DiseasesCardiovascular SystemCoronary Artery DiseaseHumansMyocardial IschemiaStress, PsychologicalConceptsPsychological stressCardiovascular diseaseMental stress-induced myocardial ischemiaStress-induced myocardial ischemiaMental stressVascular smooth muscleMental stress effectsVascular systemCardiovascular imaging modalitiesEntire vascular systemCardiovascular manifestationsVascular effectsMicrovascular resistanceMicrovascular responsesVascular changesVascular mechanismsVascular responsesCardiovascular responsesMyocardial ischemiaLong-term consequencesSmooth muscleMicrovascular compartmentTherapeutic interventionsReviewThis reviewStandardized psychological assessments
2017
Role of Imaging in the Management of Stable Ischemic Heart Disease An Evolving Paradigm Shift∗
Boden WE, Meadows JL. Role of Imaging in the Management of Stable Ischemic Heart Disease An Evolving Paradigm Shift∗. JACC Cardiovascular Imaging 2017, 10: 335-337. PMID: 28279381, DOI: 10.1016/j.jcmg.2016.12.009.Peer-Reviewed Original Research
2016
Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1&bgr; Production
Ceneri N, Zhao L, Young BD, Healy A, Coskun S, Vasavada H, Yarovinsky TO, Ike K, Pardi R, Qin L, Qin L, Tellides G, Hirschi K, Meadows J, Soufer R, Chun HJ, Sadeghi M, Bender JR, Morrison AR. Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1&bgr; Production. Arteriosclerosis Thrombosis And Vascular Biology 2016, 37: 328-340. PMID: 27834690, PMCID: PMC5269510, DOI: 10.1161/atvbaha.116.308507.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaAortic DiseasesApolipoproteins EAtherosclerosisCells, CulturedCoronary Artery DiseaseCoronary VesselsFemaleGenetic Predisposition to DiseaseHumansInflammation MediatorsInterleukin 1 Receptor Antagonist ProteinInterleukin-1betaMacrophagesMaleMice, Inbred C57BLMice, KnockoutMuscle, Smooth, VascularMyocytes, Smooth MuscleNeuropeptidesPhenotypePlaque, AtheroscleroticPrognosisRac GTP-Binding ProteinsRac1 GTP-Binding ProteinSignal TransductionTransfectionUp-RegulationVascular CalcificationConceptsCoronary calcium burdenIL-1β expressionCalcium burdenSerum IL-1β levelsElevated IL-1βIL-1β levelsCoronary artery diseaseInterleukin-1β expressionCalcified coronary arteryCardiovascular deathCardiovascular eventsArtery diseaseIndependent predictorsClinical outcomesVascular calcificationCoronary arteryIL-1βPlaque calciumAtherosclerotic calcificationExperimental atherogenesisInflammatory regulatorsMacrophage interleukinAtherosclerotic plaquesTherapeutic targetProgressive calcification