2012
The heart rate response to adenosine: A simple predictor of adverse cardiac outcomes in asymptomatic patients with type 2 diabetes
Hage FG, Wackers FJ, Bansal S, Chyun DA, Young LH, Inzucchi SE, Iskandrian AE. The heart rate response to adenosine: A simple predictor of adverse cardiac outcomes in asymptomatic patients with type 2 diabetes. International Journal Of Cardiology 2012, 167: 2952-2957. PMID: 22981277, PMCID: PMC3723723, DOI: 10.1016/j.ijcard.2012.08.011.Peer-Reviewed Original ResearchConceptsAbnormal myocardial perfusion imagingMyocardial perfusion imagingHeart rate responseCardiac eventsMPI abnormalitiesAsymptomatic patientsAdenosine myocardial perfusion imagingHard cardiac event rateCardiovascular risk factor managementCox proportional regression modelType 2 diabetes mellitusAsymptomatic Diabetics (DIAD) studyCardiac event rateNonfatal myocardial infarctionCardiac autonomic neuropathyRate responseRisk factor managementYears of followAdverse cardiac outcomesProportional regression modelHigh cardiac riskType 2 diabetesDetection of ischemiaAbnormal HRRAutonomic neuropathy
2011
85% of maximal age-predicted heart rate is not a valid endpoint for exercise treadmill testing
Jain M, Nkonde C, Lin BA, Walker A, Wackers FJ. 85% of maximal age-predicted heart rate is not a valid endpoint for exercise treadmill testing. Journal Of Nuclear Cardiology 2011, 18: 1026-1035. PMID: 21922347, DOI: 10.1007/s12350-011-9454-0.Peer-Reviewed Original ResearchConceptsMaximal age-predicted heart rateAge-predicted heart rateInducible ischemiaPeak exerciseExercise testingPositive ECGHeart rateExercise endpointPositive exercise ECGExercise treadmill testingRegistry patientsProspective registryExercise capacityRetrospective cohortTreadmill testingPatient cohortExercise ECGValid endpointPatientsMore womenEndpointIschemiaClinical laboratoriesECGCohort
2004
Cardiac Abnormalities in Diabetic Patients With Neuropathy
Johnson BF, Nesto RW, Pfeifer MA, Slater WR, Vinik AI, Chyun DA, Law G, Wackers FJ, Young LH. Cardiac Abnormalities in Diabetic Patients With Neuropathy. Diabetes Care 2004, 27: 448-454. PMID: 14747227, DOI: 10.2337/diacare.27.2.448.Peer-Reviewed Original ResearchMeSH KeywordsAldehyde ReductaseBenzothiazolesCardiac OutputDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic NeuropathiesDouble-Blind MethodEnzyme InhibitorsExercise TestFemaleHeartHeart Conduction SystemHeart RateHumansMaleMiddle AgedPhthalazinesPlacebosStroke VolumeThiazolesVentricular Function, LeftConceptsLeft ventricular ejection fractionDiabetic patientsARI treatmentCardiac outputStroke volumeCardiac abnormalitiesAldose reductase inhibitorExercise left ventricular ejection fractionAbnormal heart rate variabilityDiastolic peak filling rateAsymptomatic cardiac abnormalitiesGated radionuclide ventriculographyMaximal bicycle exercisePlacebo-treated subjectsDiastolic filling rateVentricular ejection fractionCoronary artery diseaseValvular heart diseasePeak filling rateExercise cardiac outputLV stroke volumeHeart rate variabilityBlinded treatmentInsulin useArtery disease
2001
Cardiac responses to insulin-induced hypoglycemia in nondiabetic and intensively treated type 1 diabetic patients
Russell R, Chyun D, Song S, Sherwin R, Tamborlane W, Lee F, Pfeifer M, Rife F, Wackers F, Young L. Cardiac responses to insulin-induced hypoglycemia in nondiabetic and intensively treated type 1 diabetic patients. AJP Endocrinology And Metabolism 2001, 281: e1029-e1036. PMID: 11595660, DOI: 10.1152/ajpendo.2001.281.5.e1029.Peer-Reviewed Original ResearchMeSH KeywordsAdultCardiac OutputCatecholaminesChemical PrecipitationDiabetes Mellitus, Type 1DiastoleEpinephrineFatty Acids, NonesterifiedFemaleGlucagonGlucose Clamp TechniqueHeartHeart RateHumansHydrocortisoneHypoglycemiaInsulinLactic AcidMaleNorepinephrinePolyethylene GlycolsStroke VolumeSystoleVentricular Function, LeftConceptsType 1 diabetic patientsInsulin-induced hypoglycemiaNondiabetic groupType 1 diabetesDiabetic subjectsEuglycemic hyperinsulinemiaDiabetic patientsNondiabetic subjectsCardiac responseLeft ventricular systolicHealthy nondiabetic subjectsEquilibrium radionuclide angiographyDiabetic groupDiastolic functionVentricular systolicCardiovascular consequencesVentricular functionBlunted increaseCardiac outputGlucagon concentrationsPlasma catecholaminesRadionuclide angiographyInsulin infusionEuglycemic conditionsHypoglycemia
1989
Transient left ventricular dysfunction during provocative mental stress in patients with coronary artery disease
LaVeau P, Rozanski A, Krantz D, Cornell C, Cattanach L, Zaret B, Wackers F. Transient left ventricular dysfunction during provocative mental stress in patients with coronary artery disease. American Heart Journal 1989, 118: 1-8. PMID: 2741776, DOI: 10.1016/0002-8703(89)90064-1.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionCoronary artery diseaseCoronary diseaseMental stressArtery diseaseNormal volunteersPsychological stressVentricular ejection fractionStress-induced abnormalitiesLVEF responseChest painVentricular dysfunctionEjection fractionDouble productECG changesTransient ischemiaAcute decreaseBaseline valuesNormal subjectsStroop Color-Word TestPatientsPhysical exerciseAmbulatory monitoringImmediate reboundColor-Word Test
1988
Oral Terbutaline Augments Cardiac Performance in Chronic Obstructive Pulmonary Disease
Chan C, Loke J, Snyder P, Wackers F, Mattera J, Matthay R. Oral Terbutaline Augments Cardiac Performance in Chronic Obstructive Pulmonary Disease. The American Journal Of The Medical Sciences 1988, 296: 33-38. PMID: 3044105, DOI: 10.1097/00000441-198807000-00007.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseObstructive pulmonary diseaseVentricular ejection fractionSubmaximal steady-state exerciseOral terbutalineSteady-state exerciseEjection fractionPulmonary diseaseSevere chronic obstructive pulmonary diseaseLeft ventricular ejection fractionFirst-pass radionuclide angiographySystolic pump performancePlacebo-controlled trialState exerciseExpiratory volumeBlood pressureCardiopulmonary effectsPlacebo dayHemodynamic measurementsVital capacityRadionuclide angiographyCardiac functionSubmaximal exerciseCardiac performanceHeart rate
1981
Pathophysiologic correlates of right ventricular thallium-201 uptake in a canine model.
Wackers F, Klay J, Laks H, Schnitzer J, Zaret B, Geha A. Pathophysiologic correlates of right ventricular thallium-201 uptake in a canine model. Circulation 1981, 64: 1256-1264. PMID: 6457702, DOI: 10.1161/01.cir.64.6.1256.Peer-Reviewed Original ResearchExercise left ventricular performance in patients with chest pain, ischemic-appearing exercise electrocardiograms, and angiographically normal coronary arteries.
Berger HJ, Sands MJ, Davies RA, Wackers FJ, Alexander J, Lachman AS, Williams BW, Zaret BL. Exercise left ventricular performance in patients with chest pain, ischemic-appearing exercise electrocardiograms, and angiographically normal coronary arteries. Annals Of Internal Medicine 1981, 94: 186-91. PMID: 7469209, DOI: 10.7326/0003-4819-94-2-186.Peer-Reviewed Original ResearchConceptsNormal coronary arteriesLeft ventricular performanceChest painVentricular performanceCoronary arteryExercise electrocardiogramAbnormal ejection fraction responseMaximal upright bicycle exerciseCoronary arterial spasmUpright bicycle exerciseEjection fraction responseFirst-pass radionuclide angiocardiographyThallium-201 imagingErgonovine testingVentricular dysfunctionArterial spasmBicycle exerciseErgonovine provocationAdditional patientsTreadmill exercisePerfusion defectsRadionuclide angiocardiographyRegional dysfunctionPatientsFraction response
1980
Radionuclide assessment of right and left ventricular exercise reserve after total correction of tetralogy of Fallot
Reduto L, Berger H, Johnstone D, Hellenbrand W, Wackers F, Whittemore R, Cohen L, Gottschalk A, Zaret B, Pytlik L. Radionuclide assessment of right and left ventricular exercise reserve after total correction of tetralogy of Fallot. The American Journal Of Cardiology 1980, 45: 1013-1018. PMID: 7369132, DOI: 10.1016/0002-9149(80)90170-8.Peer-Reviewed Original ResearchConceptsVentricular ejection fraction responseRight ventricular ejection fractionRight ventricular performanceVentricular ejection fractionEjection fraction responseRight ventricular hypertrophyEjection fractionPostoperative patientsVentricular hypertrophyVentricular performanceNormal right ventricular ejection fractionFraction responseThallium-201 myocardial imagingAsymptomatic clinical statusRight ventricular uptakeTotal surgical correctionThallium-201 imagingExercise reserveVentricular uptakeConditions of restClinical statusSurgical correctionRadionuclide angiocardiographyRadionuclide assessmentPatients