1996
Serial myocardial perfusion imaging with Tc-99m-labeled myocardial perfusion imaging agents in patients receiving thrombolytic therapy for acute myocardial infarction
Wackers F. Serial myocardial perfusion imaging with Tc-99m-labeled myocardial perfusion imaging agents in patients receiving thrombolytic therapy for acute myocardial infarction. Developments In Cardiovascular Medicine 1996, 173: 1-12. DOI: 10.1007/978-94-009-0115-5_1.Peer-Reviewed Original ResearchAcute myocardial infarctionThrombolytic therapyMyocardial infarctionInfarct arteryMyocardial perfusionRecurrent myocardial infarctionInfarct artery patencyLong-term mortalityAppropriate adjunctive therapyNovel treatment strategiesTerm mortalityAdjunctive therapyArtery patencyAcute infarctionHibernating myocardiumConventional therapyUnfavorable outcomeAntithrombotic agentsTreatment strategiesComparative efficacyReocclusionPatientsInfarctionTherapyBeneficial effects
1995
Value of radionuclide rest and exercise left ventricular ejection fraction in assessing survival of patients after thrombolytic therapy for acute myocardial infarction: Results of thrombolysis in myocardial infarction (TIMI) phase II study
Zaret B, Wackers F, Terrin M, Forman S, Williams D, Knatterud G, Braunwald E, Group F. Value of radionuclide rest and exercise left ventricular ejection fraction in assessing survival of patients after thrombolytic therapy for acute myocardial infarction: Results of thrombolysis in myocardial infarction (TIMI) phase II study. Journal Of The American College Of Cardiology 1995, 26: 73-79. PMID: 7797778, DOI: 10.1016/0735-1097(95)00146-q.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionVentricular ejection fractionExercise left ventricular ejection fractionPeak exercise ejection fractionExercise ejection fractionEjection fractionAcute myocardial infarctionImportant prognostic indexThrombolytic therapyPrethrombolytic eraCardiac mortalityPrognostic indexPrognostic valueMyocardial infarctionMortality rateMyocardial Infarction Phase II (TIMI II) studyMyocardial Infarction trialRest ejection fractionSubmaximal supine exercisePhase II studySurvival of patientsResults of thrombolysisHigh mortality rateCause mortalityII studyTomographic and planar quantitation of perfusion defects on technetium 99m-labeled sestamibi scans: Evaluation in patients treated with thrombolytic therapy for acute myocardial infarction
Mortelmans L, Wackers F, Nuyts J, Scheys I, Brzostek T, Schiepers C, Lesaffre E, Suetens P, Verbruggen A, Van de Werf F. Tomographic and planar quantitation of perfusion defects on technetium 99m-labeled sestamibi scans: Evaluation in patients treated with thrombolytic therapy for acute myocardial infarction. Journal Of Nuclear Cardiology 1995, 2: 133-143. DOI: 10.1016/s1071-3581(06)80023-1.Peer-Reviewed Original Research
1993
A new quantitative method for the analysis of cardiac perfusion tomography (SPET): validation in post-infarct patients treated with thrombolytic therapy
Mortelmans L, Nuyts J, Scheys I, Wackers F, Lesaffre E, Brzostek T, De Roo M, De Geest H, Suetens P, Verbruggen A, Van de Werf F. A new quantitative method for the analysis of cardiac perfusion tomography (SPET): validation in post-infarct patients treated with thrombolytic therapy. European Journal Of Nuclear Medicine And Molecular Imaging 1993, 20: 1193-1200. PMID: 8299655, DOI: 10.1007/bf00171018.Peer-Reviewed Original ResearchConceptsEnzymatic infarct sizePerfusion defectsThrombolytic therapyVentricular functionInfarct sizeInfarct-related vesselLarge perfusion defectsThallium-201 chloridePost-infarct patientsPerfusion defect sizeGlobal ventricular functionRegional ventricular functionPerfusion tomographyContrast angiographyPatientsBeneficial effectsTherapyMyocardial perfusion tomogramsSignificant differencesPlanar quantificationValve planeFrequency and significance of right ventricular dysfunction during inferior wall left ventricular myocardial infarction treated with thrombolytic therapy (results from the Thrombolysis in Myocardial Infarction [TIMI] II trial)
Berger P, Ruocco N, Ryan T, Jacobs A, Zaret B, Wackers F, Frederick M, Faxon D, Group R. Frequency and significance of right ventricular dysfunction during inferior wall left ventricular myocardial infarction treated with thrombolytic therapy (results from the Thrombolysis in Myocardial Infarction [TIMI] II trial). The American Journal Of Cardiology 1993, 71: 1148-1152. PMID: 8097614, DOI: 10.1016/0002-9149(93)90637-r.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAngioplasty, Balloon, CoronaryCombined Modality TherapyConstriction, PathologicCoronary VesselsFemaleHeart DiseasesHeart VentriclesHumansMaleMiddle AgedMyocardial InfarctionRadionuclide VentriculographyThrombolytic TherapyTissue Plasminogen ActivatorVentricular Function, LeftVentricular Function, RightConceptsRV wall motion abnormalitiesRight ventricular dysfunctionRV dysfunctionVentricular myocardial infarctionWall motion abnormalitiesVentricular dysfunctionThrombolytic therapyRadionuclide ventriculographyMyocardial infarctionMotion abnormalitiesInferior wallLower mean left ventricular ejection fractionMean left ventricular ejection fractionLeft ventricular ejection fractionBaseline clinical characteristicsInfarct-related arteryMyocardial Infarction (TIMI) II trialVentricular ejection fractionEquilibrium radionuclide ventriculographyHospital complicationsMultivessel diseaseII trialClinical characteristicsHospital dischargeEjection fraction
1992
Assessment of global and regional left ventricular performance at rest and during exercise after thrombolytic therapy for acute myocardial infarction: Results of the Thrombolysis in Myocardial Infarction (TIMI) II study
Zaret B, Wackers F, Terrin M, Ross R, Weiss M, Slater J, Morrison J, Bourge R, Passamani E, Knatterud G, Braunwald E, Investigators. Assessment of global and regional left ventricular performance at rest and during exercise after thrombolytic therapy for acute myocardial infarction: Results of the Thrombolysis in Myocardial Infarction (TIMI) II study. The American Journal Of Cardiology 1992, 69: 1-9. PMID: 1729855, DOI: 10.1016/0002-9149(92)90667-n.Peer-Reviewed Original ResearchConceptsLV ejection fractionLeft ventricular performanceEjection fractionRegional left ventricular performanceRegional ejection fractionHospital dischargeThrombolytic therapyVentricular performanceTreatment strategiesStrategies patientsComparable work loadNormal exercise responseRegional LV performanceMyocardial Infarction (TIMI) II trialAcute myocardial infarctionHospital-discharged patientsConservative strategyII studyII trialDischarge patientsConservative patientsClinical benefitLV performanceExercise studiesMyocardial infarctionTc-99m SestaMIBI: Will it replace Tl-201 in clinical cardiology?
Wackers F. Tc-99m SestaMIBI: Will it replace Tl-201 in clinical cardiology? Developments In Cardiovascular Medicine 1992, 128: 239-248. DOI: 10.1007/978-94-011-2666-3_16.Peer-Reviewed Original ResearchCoronary artery diseaseArtery diseaseEjection fractionPharmacological vasodilatationPhysical exerciseTl-201Regional wall motion studiesFirst-pass ejection fractionVentricular ejection fractionSize of infarctionAcute myocardial infarctionMyocardial perfusion imagingRegional wall motionMyocardial blood flowWall motion studiesThousands of patientsLower extraction fractionMyocardial salvageThrombolytic therapyVentricular functionCoronary occlusionMyocardial infarctionMyocardial ischemiaSestamibi imagingMyocardial viability
1991
Does left ventricular ejection fraction following thrombolytic therapy have the same prognostic impact described in the prethrombolytic era? Results of the TIMI II trail
Zaret B, Wackers F, Terrin M, Ross R, Knatterud G, Braunwald E, Investigators. Does left ventricular ejection fraction following thrombolytic therapy have the same prognostic impact described in the prethrombolytic era? Results of the TIMI II trail. Journal Of The American College Of Cardiology 1991, 17: a214. DOI: 10.1016/0735-1097(91)91821-u.Peer-Reviewed Original Research
1990
Thrombolytic therapy for myocardial infarction: Assessment of efficacy by myocardial perfusion imaging with technetium-99m sestamibi
Wackers F. Thrombolytic therapy for myocardial infarction: Assessment of efficacy by myocardial perfusion imaging with technetium-99m sestamibi. The American Journal Of Cardiology 1990, 66: e36-e41. PMID: 2145744, DOI: 10.1016/0002-9149(90)90610-d.Peer-Reviewed Original ResearchConceptsRecombinant tissue-type plasminogen activatorThrombolytic therapyMyocardial infarctionFirst acute myocardial infarctionInfarct-related artery patencyInitial risk areaPersistent coronary occlusionAcute chest painAcute myocardial infarctionAssessment of efficacyFuture clinical researchImaging agentNew thrombolytic agentsTissue-type plasminogen activatorArtery patencyChest painInfarct arterySuccessful thrombolysisConventional therapyCoronary occlusionHypoperfused myocardiumThrombolytic agentsMyocardial perfusionPatientsEnd pointMyocardial Perfusion Scintigraphy as an Aid in Understanding Electrocardiographic Changes of Ischemia and Infarction
ZARET B, WACKERS F. Myocardial Perfusion Scintigraphy as an Aid in Understanding Electrocardiographic Changes of Ischemia and Infarction. Annals Of The New York Academy Of Sciences 1990, 601: 107-118. PMID: 2221682, DOI: 10.1111/j.1749-6632.1990.tb37296.x.Peer-Reviewed Original ResearchConceptsMyocardial perfusion scintigraphyPerfusion scintigraphyMyocardial ischemiaPresence of reperfusionChronic coronary syndromeChronic coronary diseaseChronic myocardial ischemiaSignificant Q wavesElectrocardiographic documentationCoronary syndromeCoronary diseaseElectrocardiographic changesThrombolytic therapyMyocardial infarctionLimitations of electrocardiographyPharmacologic stressPrognostic evaluationQ wavesInfarct zoneScintigraphyIschemiaInfarctionPatientsCumulative experienceReperfusionSilent left ventricular dysfunction during routine activity after thrombolytic Therapy for acute myocardial infarction
Kayden D, Wackers F, Zaret B. Silent left ventricular dysfunction during routine activity after thrombolytic Therapy for acute myocardial infarction. Journal Of The American College Of Cardiology 1990, 15: 1500-1507. PMID: 2345230, DOI: 10.1016/0735-1097(90)92817-l.Peer-Reviewed Original ResearchConceptsTransient left ventricular dysfunctionLeft ventricular dysfunctionSilent left ventricular dysfunctionVentricular dysfunctionMyocardial infarctionCardiac eventsHospital dischargeEjection fractionThrombolytic therapySubmaximal supine bicycle exerciseNormal activityBaseline ejection fractionExercise test resultsSubsequent cardiac eventsSupine bicycle exerciseVentricular function monitoringAcute myocardial infarctionChest painPeak exerciseBicycle exerciseAmbulatory patientsElectrocardiographic changesPoor outcomePrognostic informationFunction monitoring
1989
Feasibility of tomographic 99mTc-hexakis-2-methoxy-2-methylpropyl-isonitrile imaging for the assessment of myocardial area at risk and the effect of treatment in acute myocardial infarction.
Gibbons R, Verani M, Behrenbeck T, Pellikka P, O'Connor M, Mahmarian J, Chesebro J, Wackers F. Feasibility of tomographic 99mTc-hexakis-2-methoxy-2-methylpropyl-isonitrile imaging for the assessment of myocardial area at risk and the effect of treatment in acute myocardial infarction. Circulation 1989, 80: 1277-1286. PMID: 2530004, DOI: 10.1161/01.cir.80.5.1277.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionThrombolytic therapyTc-sestamibiHypoperfused myocardiumMyocardial perfusionLeft ventricleIntravenous tissue-type plasminogen activatorRegional wall motion scoreIntravenous thrombolytic therapyWall motion scoreTime of administrationEffect of treatmentSingle photon emissionTissue-type plasminogen activatorEjection fractionAnterior infarctsHypoperfused regionsInferior infarctsSimilar injectionsIntravenous injectionMotion scoreInfarctionMyocardial areaInfarct segmentsSerial quantitative planar technetium-99m isonitrile imaging in acute myocardial infarction: Efficacy for noninvasive assessment of thrombolytic therapy
Wackers F, Gibbons R, Verani M, Kayden D, Pellikka P, Behrenbeck T, Mahmarian J, Zaret B. Serial quantitative planar technetium-99m isonitrile imaging in acute myocardial infarction: Efficacy for noninvasive assessment of thrombolytic therapy. Journal Of The American College Of Cardiology 1989, 14: 861-873. PMID: 2507612, DOI: 10.1016/0735-1097(89)90456-7.Peer-Reviewed Original ResearchConceptsRecombinant tissue-type plasminogen activatorAcute myocardial infarctionPatent infarct-related arteryInfarct-related arteryThallium-201 imagingThrombolytic therapyMyocardial infarctionPlanar technetiumMyocardial perfusionExercise thallium-201 imagingFirst acute myocardial infarctionInfarct-related artery patencyInitial risk areaPersistent coronary occlusionSuccess of reperfusionMyocardial blood flowNew myocardial perfusionTissue-type plasminogen activatorArtery patencyChest painCoronary occlusionRepeat imagingBlood flowInfarctionThallium-201Quantitative radionuclide assessment of regional ventricular function after thrombolytic therapy for acute myocardial infarction: Results of phase I Thrombolysis in Myocardial Infarction (TIMI) trial
Wackers F, Terrin M, Kayden D, Knatterud G, Forman S, Braunwald E, Zaret B, Investigators. Quantitative radionuclide assessment of regional ventricular function after thrombolytic therapy for acute myocardial infarction: Results of phase I Thrombolysis in Myocardial Infarction (TIMI) trial. Journal Of The American College Of Cardiology 1989, 13: 998-1005. PMID: 2494246, DOI: 10.1016/0735-1097(89)90250-7.Peer-Reviewed Original ResearchConceptsRecombinant tissue-type plasminogen activatorLeft ventricular ejection fractionInfarct-related arteryVentricular ejection fractionGlobal left ventricular ejection fractionRegional left ventricular functionLeft ventricular functionEjection fractionAcute myocardial infarctionRegional ejection fractionVentricular functionMyocardial infarctionMean global left ventricular ejection fractionIntravenous recombinant tissue-type plasminogen activatorRegional left ventricular ejection fractionEffect of thrombolysisMyocardial Infarction trialRegional ventricular functionTissue-type plasminogen activatorPatients 185Sustained reperfusionIntravenous streptokinaseAngiographic reperfusionThrombolytic therapyPatency rates
1988
Demonstration of reperfusion after thrombolysis with technetium-99m isonitrile myocardial imaging.
Kayden D, Mattera J, Zaret B, Wackers F. Demonstration of reperfusion after thrombolysis with technetium-99m isonitrile myocardial imaging. Journal Of Nuclear Medicine 1988, 29: 1865-7. PMID: 2972815.Peer-Reviewed Original ResearchConceptsThrombolytic therapyMyocardial infarctionRecombinant tissue plasminogen activatorAcute anteroseptal myocardial infarctionSuccess of reperfusionSalvage of myocardiumAcute myocardial infarctionAnteroseptal myocardial infarctionMyocardial perfusion defectsMyocardial perfusion imagingTissue plasminogen activatorEmergency roomRepeat injectionsPerfusion defectsIntravenous injectionMyocardial imagingPerfusion imagingMyocardial redistributionInfarctionNoninvasive meansPlasminogen activatorReperfusionImaging agentTherapyTechnetiumElectrophysiologic effects of thrombolytic therapy in patients with a transmural anterior myocardial infarction complicated by left ventricular aneurysm formation
Sager P, Perlmutter R, Rosenfeld L, McPherson C, Wackers F, Batsford W. Electrophysiologic effects of thrombolytic therapy in patients with a transmural anterior myocardial infarction complicated by left ventricular aneurysm formation. Journal Of The American College Of Cardiology 1988, 12: 19-24. PMID: 3379204, DOI: 10.1016/0735-1097(88)90350-6.Peer-Reviewed Original ResearchConceptsGroup B patientsLeft ventricular aneurysm formationTransmural anterior myocardial infarctionGroup A patientsVentricular aneurysm formationAnterior myocardial infarctionThrombolytic therapyB patientsVentricular tachycardiaA patientsVentricular arrhythmiasMyocardial infarctionAneurysm formationNew bundle branch blockPeak creatine kinase-MB levelsLeft ventricular ejection fractionCreatine kinase-MB levelsClinical arrhythmic eventsEarly thrombolytic therapyCongestive heart failureVentricular ejection fractionSustained ventricular tachycardiaInduced ventricular arrhythmiasBundle branch blockPostmyocardial infarction patientsThe Role of Nuclear Cardiology in Assessment of Acute Myocardial Infarction
den D, Wackers F, Zaret B. The Role of Nuclear Cardiology in Assessment of Acute Myocardial Infarction. Cardiology Clinics 1988, 6: 81-95. PMID: 3048676, DOI: 10.1016/s0733-8651(18)30503-4.Peer-Reviewed Original ResearchConceptsConvalescent phaseVentricular functionExercise-induced ischemiaAcute myocardial infarctionSalvaged myocardiumThallium imagingThrombolytic therapyAcute interventionIschemic myocardiumMyocardial infarctionPrognostic informationFurther interventionMyocardial perfusionPerfusion imagingAmbulatory monitoringMetabolic imagingMyocardiumNuclear cardiologyAppropriate management strategiesInterventionImagingInfarctionIschemiaPatientsTherapy