2011
SCREENING ASYMPTOMATIC PATIENTS WITH TYPE 2 DIABETES FOR SILENT MYOCARDIAL ISCHEMIA: IMPORTANT GENDER DIFFERENCES FROM THE DETECTION OF ISCHEMIA IN ASYMPTOMATIC DIABETICS (DIAD) STUDY
Tandon S, Bansal S, Inzucchi S, Staib L, Davey J, Chyun D, Young L, Wackers F. SCREENING ASYMPTOMATIC PATIENTS WITH TYPE 2 DIABETES FOR SILENT MYOCARDIAL ISCHEMIA: IMPORTANT GENDER DIFFERENCES FROM THE DETECTION OF ISCHEMIA IN ASYMPTOMATIC DIABETICS (DIAD) STUDY. Journal Of The American College Of Cardiology 2011, 57: e745. DOI: 10.1016/s0735-1097(11)60745-6.Peer-Reviewed Original Research
2007
Resolution of Asymptomatic Myocardial Ischemia in Patients With Type 2 Diabetes in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) Study
Wackers FJ, Chyun DA, Young LH, Heller GV, Iskandrian AE, Davey JA, Barrett EJ, Taillefer R, Wittlin SD, Filipchuk N, Ratner RE, Inzucchi SE. Resolution of Asymptomatic Myocardial Ischemia in Patients With Type 2 Diabetes in the Detection of Ischemia in Asymptomatic Diabetics (DIAD) Study. Diabetes Care 2007, 30: 2892-2898. PMID: 17682123, DOI: 10.2337/dc07-1250.Peer-Reviewed Original ResearchConceptsResolution of ischemiaType 2 diabetesDetection of ischemiaNew ischemiaAsymptomatic Diabetics (DIAD) studyCardiovascular risk factorsAsymptomatic myocardial ischemiaAdenosine stress myocardial perfusionRepeat stressIschemia increasesAsymptomatic patientsCardiac eventsMore patientsACE inhibitorsMyocardial ischemiaRisk factorsIntensive treatmentDiabetic studyIschemiaMyocardial perfusionPatientsMedical treatmentDiabetesInitial evaluationGreater increase
2006
Value of peripheral vascular endothelial function in the detection of relative myocardial ischemia in asymptomatic type 2 diabetic patients who underwent myocardial perfusion imaging
Papaioannou GI, Kasapis C, Seip RL, Grey NJ, Katten D, Wackers FJ, Inzucchi SE, Engel S, Taylor A, Young LH, Chyun DA, Davey JA, Iskandrian AE, Ratner RE, Robinson EC, Carolan S, Heller GV. Value of peripheral vascular endothelial function in the detection of relative myocardial ischemia in asymptomatic type 2 diabetic patients who underwent myocardial perfusion imaging. Journal Of Nuclear Cardiology 2006, 13: 362-368. PMID: 16750781, DOI: 10.1016/j.nuclcard.2006.01.022.Peer-Reviewed Original ResearchConceptsEndothelium-dependent vasodilationEndothelium-independent vasodilationCoronary artery diseaseMyocardial perfusion imagingRelative myocardial ischemiaAsymptomatic patientsEndothelial functionNegative predictive valueMyocardial ischemiaAsymptomatic type 2 diabetic patientsExclusion of CADPredictive valueAdenosine myocardial perfusion imagingPeripheral vascular endothelial functionType 2 diabetic patientsType 2 diabetes mellitusHigh negative predictive valueAsymptomatic Diabetics (DIAD) studyBrachial artery ultrasonographyVascular endothelial functionDetection of ischemiaEDV responseRelative ischemiaEndothelial dysfunctionOvert atherosclerosisThe Impact of Screening for Asymptomatic Myocardial Ischemia in Individuals With Type 2 Diabetes
Chyun DA, Katten DM, Melkus GD, Talley S, Davey JA, Wackers FJ. The Impact of Screening for Asymptomatic Myocardial Ischemia in Individuals With Type 2 Diabetes. The Journal Of Cardiovascular Nursing 2006, 21: e1-e7. PMID: 16601520, DOI: 10.1097/00005082-200603000-00015.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAntihypertensive AgentsAnxietyAspirinDepressionDiabetes Mellitus, Type 2EmotionsFemaleFibrinolytic AgentsFollow-Up StudiesHealth BehaviorHumansHypolipidemic AgentsMaleMass ScreeningMiddle AgedMotor ActivityMultivariate AnalysisMyocardial IschemiaPersonal AutonomyProspective StudiesQuality of LifeRisk AssessmentSocioeconomic FactorsConceptsCoronary artery diseaseType 2 diabetesAsymptomatic coronary artery diseasePoor emotional outcomesAsymptomatic myocardial ischemiaRisk factor behaviorsImpact of screeningSelf-administered questionnaireAggressive screeningArtery diseaseProspective studyStudy baselineMyocardial ischemiaScreening TrialMyocardial perfusionEmotional outcomesOutcomesDiabetesBehavior outcomesLaboratory testsLow levelsScreeningHigh levelsIschemiaPerfusion
2004
Abnormal heart rate response to adenosine infusion is associated with silent myocardial ischemia in asymptomatic patients with diabetes mellitus
Sudhakar S, Chyun D, Young L, Inzucchi S, Davey J, Wackers F. Abnormal heart rate response to adenosine infusion is associated with silent myocardial ischemia in asymptomatic patients with diabetes mellitus. Journal Of Nuclear Cardiology 2004, 11: s20. DOI: 10.1016/j.nuclcard.2004.06.064.Peer-Reviewed Original ResearchHeart rate responseSilent myocardial ischemiaLarge myocardial perfusion defectsMyocardial perfusion defectsLarger perfusion abnormalityAsymptomatic patientsNegative predictive valuePerfusion abnormalitiesMyocardial ischemiaPerfusion defectsAdenosine infusionRate responsePredictive valueAbnormal heart rate responseBlunted heart rate responseHigh negative predictive valueLower heart rate responseCoronary artery diseaseMyocardial perfusion abnormalitiesDetection of ischemiaMales 53Autonomic neuropathyArtery diseaseDiabetes mellitusPoor outcome
2002
Pharmacologic stress perfusion imaging with adenosine: Role of simultaneous low-level treadmill exercise
Samady H, Wackers FJ, Joska TM, Zaret BL, Jain D. Pharmacologic stress perfusion imaging with adenosine: Role of simultaneous low-level treadmill exercise. Journal Of Nuclear Cardiology 2002, 9: 188-196. PMID: 11986564, DOI: 10.1067/mnc.2002.119973.Peer-Reviewed Original ResearchConceptsLow-level treadmill exerciseMyocardial perfusion imagingTreadmill exerciseElectrocardiographic changesAdverse effectsAdenosine myocardial perfusion imagingSestamibi single-photon emissionPharmacologic stress myocardial perfusion imagingStress myocardial perfusion imagingIschemic electrocardiographic changesLow-level exerciseMore adverse effectsUnfavorable side effectsSingle photon emissionAdenosine studyAdenosine TcMore patientsMyocardial ischemiaHemodynamic responseStress perfusionSide effectsPerfusion imagingTracer uptakePatientsMPI studies
1996
Quantitative comparison of single-isotope and dual-isotope stress-rest single-photon emission computed tomographic imaging for reversibility of defects
Siebelink H, Natale D, Sinusas A, Wackers F. Quantitative comparison of single-isotope and dual-isotope stress-rest single-photon emission computed tomographic imaging for reversibility of defects. Journal Of Nuclear Cardiology 1996, 3: 483-493. PMID: 8989673, DOI: 10.1016/s1071-3581(96)90058-6.Peer-Reviewed Original ResearchConceptsDefect reversibilitySingle photon emissionDual-isotope SPECTNormal databaseStress-rest single-photon emissionTechnetium 99m-labeled sestamibiStress-induced myocardial ischemiaStress single-photon emissionPerfusion defect reversibilityPrior myocardial infarctionDefect sizeRest/stressSingle-isotope imagingMyocardial infarctionThallium SPECTMyocardial ischemiaIndividual patientsMyocardial perfusionThallium-201PatientsSestamibiCircumferential count profilesTomographic imagingImaging protocolDual-isotope imagingDetection and significance of myocardial ischemia in women versus men within six months of acute myocardial infarction or unstable angina
Moriel M, Benhorin J, Brown M, Raubertas R, Severski P, Van Voorhees L, Bodenheimer M, Tzivoni D, Wackers F, Moss A, Group T. Detection and significance of myocardial ischemia in women versus men within six months of acute myocardial infarction or unstable angina. The American Journal Of Cardiology 1996, 77: 798-804. PMID: 8623730, DOI: 10.1016/s0002-9149(97)89172-2.Peer-Reviewed Original ResearchConceptsAcute coronary eventsThallium-201 stress scintigraphyPrimary end pointCoronary eventsEnd pointUnstable anginaStress scintigraphyPatient 1Myocardial infarctionNoninvasive testsExercise electrocardiogramAmbulatory electrocardiogramIschemia detectionCardiac event rateNonfatal myocardial infarctionSubsequent cardiac eventsAcute myocardial infarctionCardiac eventsIschemia testCardiac deathCox analysisPrognostic significanceMyocardial ischemiaEvent ratesWomen
1995
Technetium-99m-nitroimidazole (BMS181321): a positive imaging agent for detecting myocardial ischemia.
Shi CQ, Sinusas AJ, Dione DP, Singer MJ, Young LH, Heller EN, Rinker BD, Wackers FJ, Zaret BL. Technetium-99m-nitroimidazole (BMS181321): a positive imaging agent for detecting myocardial ischemia. Journal Of Nuclear Medicine 1995, 36: 1078-86. PMID: 7769431.Peer-Reviewed Original ResearchConceptsIschemic regionMyocardial ischemiaBlood flowEx vivo SPECTRegional myocardial blood flowPartial coronary occlusionMicrosphere blood flowMyocardial blood flowOpen-chest canine modelVivo SPECT imagesSPECT imagesVivo planarCentral ischemic regionCoronary occlusionDemand ischemiaBMS181321Technetium-99mIntravenous injectionLiver ratioMyocardial imagingCanine modelPositive imagingHepatic clearanceLiver activityArterial sampling
1994
Prognostic significance of a fixed thallium defect one to six months after onset of acute myocardial infarction or unstable angina
Bodenheimer M, Wackers F, Schwartz R, Brown M, Group T. Prognostic significance of a fixed thallium defect one to six months after onset of acute myocardial infarction or unstable angina. The American Journal Of Cardiology 1994, 74: 1196-1200. PMID: 7977089, DOI: 10.1016/0002-9149(94)90547-9.Peer-Reviewed Original ResearchConceptsNonfatal infarctionCardiac eventsUnstable anginaCardiac deathMyocardial infarctionReversible defectsExercise thallium studiesNonfatal myocardial infarctionAcute coronary eventsLarge prospective studiesAcute cardiac eventsKaplan-Meier curvesAcute myocardial infarctionLog-rank statisticsCoronary eventsExercise thalliumPatient 1Prognostic significanceProspective studyMyocardial ischemiaThallium studiesThallium testThallium imagesInfarctionPatientsEffects of altered left ventricular geometry on quantitative technetium 99m sestamibi defect size in humans: Perfusion imaging during coronary angioplasty
Haronian H, Sinusas A, Remetz M, Brennan J, Cabin H, Zaret B, Wackers F. Effects of altered left ventricular geometry on quantitative technetium 99m sestamibi defect size in humans: Perfusion imaging during coronary angioplasty. Journal Of Nuclear Cardiology 1994, 1: 150-158. PMID: 9420682, DOI: 10.1007/bf02984087.Peer-Reviewed Original ResearchConceptsPercutaneous transluminal coronary angioplastyLeft ventricular geometryAltered left ventricular geometryCoronary angioplastyRegional wall motionVentricular geometryEnd-diastolic imagesMyocardial perfusionExercise-induced myocardial ischemiaAbnormal regional wall motionMyocardial risk areaTransluminal coronary angioplastyQuantitative defectsExperimental animal modelsPlanar myocardial perfusionMyocardial perfusion imagingQuantitative technetiumResultsNine patientsVentricular functionCoronary arteryMyocardial infarctionVessel occlusionMyocardial ischemiaPerfusion defectsWall motion
1993
Detection and Significance of Myocardial Ischemia in Stable Patients After Recovery From an Acute Coronary Event
Moss A, Goldstein R, Hall W, Bigger J, Fleiss J, Greenberg H, Bodenheimer M, Krone R, Marcus F, Wackers F, Benhorin J, Brown M, Case R, Coromilas J, Dwyer E, Gillespie J, Gregory J, Kleiger R, Lichstein E, Parker J, Raubertas R, Stern S, Tzivoni D, Van Voorhees L, Krasicky G, Shah R, Walroth J, Greengart A, Moriel M, Challis T, Blood D, Rolnitzky L, DePuey G, Kuller L, Odoroff C, Schwartz R, Annechiarico R, Andrews M, Severski P, Ma G, Edwards J, Fischer K, Freedland K, Cobb L, Korsten J, Williams W, Algeo S, Chandysson P. Detection and Significance of Myocardial Ischemia in Stable Patients After Recovery From an Acute Coronary Event. JAMA 1993, 269: 2379-2385. DOI: 10.1001/jama.1993.03500180071037.Peer-Reviewed Original ResearchAcute coronary eventsSymptomatic myocardial ischemiaCoronary eventsST depressionMyocardial ischemiaNoninvasive testingExercise-induced ST depressionReversible thallium-201 defectsSubsequent coronary eventsHigh-risk subsetST-segment depressionThallium-201 scintigraphyThallium-201 defectsAcute myocardial infarctionNoninvasive test resultsPrimary eventFirst primary eventsPostcoronary patientsRecent hospitalizationSegment depressionUnstable anginaAmbulatory outpatientsCohort studyStable patientsExercise durationDetection and significance of myocardial ischemia in stable patients after recovery from an acute coronary event. Multicenter Myocardial Ischemia Research Group.
Moss A, Goldstein R, Hall W, Bigger J, Fleiss J, Greenberg H, Bodenheimer M, Krone R, Marcus F, Wackers F. Detection and significance of myocardial ischemia in stable patients after recovery from an acute coronary event. Multicenter Myocardial Ischemia Research Group. JAMA 1993, 269: 2379-85. PMID: 8479063, DOI: 10.1001/jama.269.18.2379.Peer-Reviewed Original ResearchConceptsAcute coronary eventsSymptomatic myocardial ischemiaCoronary eventsST depressionMyocardial ischemiaExercise-induced ST depressionReversible thallium-201 defectsSubsequent coronary eventsHigh-risk subsetST-segment depressionThallium-201 scintigraphyThallium-201 defectsAcute myocardial infarctionNoninvasive test resultsPrimary eventFirst primary eventsNon-invasive testingPostcoronary patientsRecent hospitalizationSegment depressionUnstable anginaAmbulatory outpatientsStable patientsExercise durationLung uptakeFactors affecting uniformity in interpretation of planar thallium-201 imaging in a Multicenter trial
Wackers F, Bodenheimer M, Fleiss J, Brown M, Investigators T. Factors affecting uniformity in interpretation of planar thallium-201 imaging in a Multicenter trial. Journal Of The American College Of Cardiology 1993, 21: 1064-1074. PMID: 8459059, DOI: 10.1016/0735-1097(93)90226-q.Peer-Reviewed Original ResearchConceptsClinical centersThallium-201 imagesCore laboratoryClinical investigatorsSilent myocardial ischemiaPlanar thallium-201 imagesThallium-201 imagingLack of standardizationCircumferential profile analysisPlanar thallium-201 imagingReproducibility of interpretationMulticenter trialMulticenter studyMyocardial ischemiaMyocardial perfusion imagesSuboptimal reproducibilityInterobserver agreementKappa statisticsPerfusion imagesPoor interlaboratory agreementComputer quantificationObjective criteriaInterlaboratory agreementPoor agreementEffects of standardization
1992
Tc-99m SestaMIBI: Will it replace Tl-201 in clinical cardiology?
Wackers F. Tc-99m SestaMIBI: Will it replace Tl-201 in clinical cardiology? Developments In Cardiovascular Medicine 1992, 128: 239-248. DOI: 10.1007/978-94-011-2666-3_16.Peer-Reviewed Original ResearchCoronary artery diseaseArtery diseaseEjection fractionPharmacological vasodilatationPhysical exerciseTl-201Regional wall motion studiesFirst-pass ejection fractionVentricular ejection fractionSize of infarctionAcute myocardial infarctionMyocardial perfusion imagingRegional wall motionMyocardial blood flowWall motion studiesThousands of patientsLower extraction fractionMyocardial salvageThrombolytic therapyVentricular functionCoronary occlusionMyocardial infarctionMyocardial ischemiaSestamibi imagingMyocardial viability
1991
Validation of continuous radionuclide left ventricular functioning monitoring in detecting silent myocardial ischemia during balloon angioplasty of the left anterior descending coronary artery
Kayden D, Remetz M, Cabin H, Deckelbaum L, Cleman M, Wackers F, Zaret B. Validation of continuous radionuclide left ventricular functioning monitoring in detecting silent myocardial ischemia during balloon angioplasty of the left anterior descending coronary artery. The American Journal Of Cardiology 1991, 67: 1339-1343. PMID: 2042565, DOI: 10.1016/0002-9149(91)90462-t.Peer-Reviewed Original ResearchConceptsSilent myocardial ischemiaLV ejection fractionLV dysfunctionMyocardial ischemiaEjection fractionLV functionBalloon inflationRelative end-systolic volumeTransient ST-segment depressionPercutaneous transluminal coronary angioplastyMean LV ejection fractionST-segment depressionContinuous electrocardiographic monitoringTransluminal coronary angioplastyLeft ventricular functionST-segment changesEnd-diastolic volumeEnd-systolic volumeIschemic decreaseCoronary angioplastyVentricular functionElectrocardiographic changesElectrocardiographic monitoringBalloon angioplastyCoronary artery
1990
Myocardial Perfusion Scintigraphy as an Aid in Understanding Electrocardiographic Changes of Ischemia and Infarction
ZARET B, WACKERS F. Myocardial Perfusion Scintigraphy as an Aid in Understanding Electrocardiographic Changes of Ischemia and Infarction. Annals Of The New York Academy Of Sciences 1990, 601: 107-118. PMID: 2221682, DOI: 10.1111/j.1749-6632.1990.tb37296.x.Peer-Reviewed Original ResearchConceptsMyocardial perfusion scintigraphyPerfusion scintigraphyMyocardial ischemiaPresence of reperfusionChronic coronary syndromeChronic coronary diseaseChronic myocardial ischemiaSignificant Q wavesElectrocardiographic documentationCoronary syndromeCoronary diseaseElectrocardiographic changesThrombolytic therapyMyocardial infarctionLimitations of electrocardiographyPharmacologic stressPrognostic evaluationQ wavesInfarct zoneScintigraphyIschemiaInfarctionPatientsCumulative experienceReperfusion
1980
Current Status of Radionuclide Imaging in the Management and Evaluation of patients with cardiovascular Disease
Wackers F. Current Status of Radionuclide Imaging in the Management and Evaluation of patients with cardiovascular Disease. Advances In Cardiology 1980, 27: 40-50. PMID: 7004129, DOI: 10.1159/000383973.Peer-Reviewed Original Research