2011
Non-invasive imaging in acute chest pain syndromes
Sechtem U, Achenbach S, Friedrich M, Wackers F, Zamorano J. Non-invasive imaging in acute chest pain syndromes. European Heart Journal - Cardiovascular Imaging 2011, 13: 69-78. PMID: 22094238, DOI: 10.1093/ejechocard/jer250.Peer-Reviewed Original Research
1999
Ejection fraction by radionuclide ventriculography and contrast left ventriculogram A tale of two techniques
Ureña P, Lamas G, Mitchell G, Flaker G, Smith S, Wackers F, McEwan P, Pfeffer M, investigators F. Ejection fraction by radionuclide ventriculography and contrast left ventriculogram A tale of two techniques. Journal Of The American College Of Cardiology 1999, 33: 180-185. PMID: 9935027, DOI: 10.1016/s0735-1097(98)00533-6.Peer-Reviewed Original ResearchConceptsRadionuclide ventriculographyEjection fractionCardiovascular eventsEvent ratesMyocardial infarctionPostinfarct patientsIndependent predictorsRisk stratificationAssess prognosisClinical eventsVentricular performanceClinical impressionPatientsMultivariate analysisPrognosisVentriculographyTercileEF measurementsBest predictorPredictorsComparative abilityCatheterizationInfarctionVentriculograms
1997
Improved diagnostic accuracy of planar imaging with technetium 99m-labeled tetrofosmin compared with thallium-201 for the detection of coronary artery disease
Khattar R, Hendel R, Crawley J, Wackers F, Rigo P, Zaret B, Sridhara B, Lahiri A. Improved diagnostic accuracy of planar imaging with technetium 99m-labeled tetrofosmin compared with thallium-201 for the detection of coronary artery disease. Journal Of Nuclear Cardiology 1997, 4: 291-297. PMID: 9278875, DOI: 10.1016/s1071-3581(97)90106-9.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseROC curve analysisPrevious myocardial infarctionArtery diseaseCurve analysisMyocardial infarctionMulticenter phase III trialTechnetium 99m-labeled tetrofosminDiagnostic accuracySingle-vessel diseasePhase III trialsCharacteristic curve analysisMultivessel diseaseIII trialsCoronary arteriographyROC curve areaThallium-201TetrofosminDiagnostic testsDiseaseDiagnostic performanceCurve areaInfarctionReference standardPlanar imaging
1996
Serial myocardial perfusion imaging with Tc-99m-labeled myocardial perfusion imaging agents in patients receiving thrombolytic therapy for acute myocardial infarction
Wackers F. Serial myocardial perfusion imaging with Tc-99m-labeled myocardial perfusion imaging agents in patients receiving thrombolytic therapy for acute myocardial infarction. Developments In Cardiovascular Medicine 1996, 173: 1-12. DOI: 10.1007/978-94-009-0115-5_1.Peer-Reviewed Original ResearchAcute myocardial infarctionThrombolytic therapyMyocardial infarctionInfarct arteryMyocardial perfusionRecurrent myocardial infarctionInfarct artery patencyLong-term mortalityAppropriate adjunctive therapyNovel treatment strategiesTerm mortalityAdjunctive therapyArtery patencyAcute infarctionHibernating myocardiumConventional therapyUnfavorable outcomeAntithrombotic agentsTreatment strategiesComparative efficacyReocclusionPatientsInfarctionTherapyBeneficial effects
1995
Tomographic and planar quantitation of perfusion defects on technetium 99m-labeled sestamibi scans: Evaluation in patients treated with thrombolytic therapy for acute myocardial infarction
Mortelmans L, Wackers F, Nuyts J, Scheys I, Brzostek T, Schiepers C, Lesaffre E, Suetens P, Verbruggen A, Van de Werf F. Tomographic and planar quantitation of perfusion defects on technetium 99m-labeled sestamibi scans: Evaluation in patients treated with thrombolytic therapy for acute myocardial infarction. Journal Of Nuclear Cardiology 1995, 2: 133-143. DOI: 10.1016/s1071-3581(06)80023-1.Peer-Reviewed Original Research
1994
Prognostic significance of a fixed thallium defect one to six months after onset of acute myocardial infarction or unstable angina
Bodenheimer M, Wackers F, Schwartz R, Brown M, Group T. Prognostic significance of a fixed thallium defect one to six months after onset of acute myocardial infarction or unstable angina. The American Journal Of Cardiology 1994, 74: 1196-1200. PMID: 7977089, DOI: 10.1016/0002-9149(94)90547-9.Peer-Reviewed Original ResearchConceptsNonfatal infarctionCardiac eventsUnstable anginaCardiac deathMyocardial infarctionReversible defectsExercise thallium studiesNonfatal myocardial infarctionAcute coronary eventsLarge prospective studiesAcute cardiac eventsKaplan-Meier curvesAcute myocardial infarctionLog-rank statisticsCoronary eventsExercise thalliumPatient 1Prognostic significanceProspective studyMyocardial ischemiaThallium studiesThallium testThallium imagesInfarctionPatients
1993
Assessing myocardial reperfusion with technetium-99m-labeled myocardial perfusion agents: basic concepts and clinical applications.
Sinusas AJ, Wackers FJ. Assessing myocardial reperfusion with technetium-99m-labeled myocardial perfusion agents: basic concepts and clinical applications. American Journal Of Cardiac Imaging 1993, 7: 24-38. PMID: 10148381.Peer-Reviewed Original ResearchConceptsVessel patencyPerfusion agentManagement of patientsAcute myocardial infarctionAssessment of reperfusionClinical applicationAcute coronary reperfusionMyocardial perfusion agentThrombolytic eraCoronary reperfusionMyocardial reperfusionPotential clinical applicationsMyocardial salvageMyocardial infarctionNoninvasive evaluationReperfusionPatencyResidual viabilityThrombolysisPatientsUnique biological propertiesBiological propertiesReocclusionInfarctionPerfusion
1992
Technetium-99m sestamibi myocardial imaging at rest for assessment of myocardial infarction and first-pass ejection fraction
Boucher C, Wackers F, Zaret B, Mena I. Technetium-99m sestamibi myocardial imaging at rest for assessment of myocardial infarction and first-pass ejection fraction. The American Journal Of Cardiology 1992, 69: 22-27. PMID: 1530901, DOI: 10.1016/0002-9149(92)90670-t.Peer-Reviewed Original ResearchConceptsWall motion abnormalitiesFirst-pass ejection fractionEjection fractionQ-wave infarctsMotion abnormalitiesQ wavesAbnormal TcMyocardial infarctionSestamibi studiesFirst-pass imagingAbility of technetiumVentricular ejection fractionOccurrence of infarctionSestamibi myocardial perfusionPerfusion abnormalitiesWall motionRegional perfusionPosterior infarctsMyocardial perfusionMyocardial segmentsPatientsInfarctionSestamibi imagesProtocol IInfarcts
1990
Myocardial Perfusion Scintigraphy as an Aid in Understanding Electrocardiographic Changes of Ischemia and Infarction
ZARET B, WACKERS F. Myocardial Perfusion Scintigraphy as an Aid in Understanding Electrocardiographic Changes of Ischemia and Infarction. Annals Of The New York Academy Of Sciences 1990, 601: 107-118. PMID: 2221682, DOI: 10.1111/j.1749-6632.1990.tb37296.x.Peer-Reviewed Original ResearchConceptsMyocardial perfusion scintigraphyPerfusion scintigraphyMyocardial ischemiaPresence of reperfusionChronic coronary syndromeChronic coronary diseaseChronic myocardial ischemiaSignificant Q wavesElectrocardiographic documentationCoronary syndromeCoronary diseaseElectrocardiographic changesThrombolytic therapyMyocardial infarctionLimitations of electrocardiographyPharmacologic stressPrognostic evaluationQ wavesInfarct zoneScintigraphyIschemiaInfarctionPatientsCumulative experienceReperfusionSerial changes in myocardial perfusion using tomographic technetium-99m-hexakis-2-methoxy-2-methylpropyl-isonitrile imaging following reperfusion therapy of myocardial infarction.
Pellikka P, Behrenbeck T, Verani M, Mahmarian J, Wackers F, Gibbons R. Serial changes in myocardial perfusion using tomographic technetium-99m-hexakis-2-methoxy-2-methylpropyl-isonitrile imaging following reperfusion therapy of myocardial infarction. Journal Of Nuclear Medicine 1990, 31: 1269-75. PMID: 2143527.Peer-Reviewed Original ResearchConceptsReperfusion therapyMyocardial infarctionTc-sestamibiAcute reperfusion therapyFirst myocardial infarctionSuccessful reperfusionTomographic myocardial perfusion imagesSerial changesHypoperfused myocardiumMean decreaseFinal studyMyocardial perfusionPatientsSignificant improvementMyocardial perfusion imagesSecond studyTherapyPerfusion imagesReperfusionInfarctionPerfusionFurther decreaseHrTomographic imagingImaging
1989
Feasibility of tomographic 99mTc-hexakis-2-methoxy-2-methylpropyl-isonitrile imaging for the assessment of myocardial area at risk and the effect of treatment in acute myocardial infarction.
Gibbons R, Verani M, Behrenbeck T, Pellikka P, O'Connor M, Mahmarian J, Chesebro J, Wackers F. Feasibility of tomographic 99mTc-hexakis-2-methoxy-2-methylpropyl-isonitrile imaging for the assessment of myocardial area at risk and the effect of treatment in acute myocardial infarction. Circulation 1989, 80: 1277-1286. PMID: 2530004, DOI: 10.1161/01.cir.80.5.1277.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionThrombolytic therapyTc-sestamibiHypoperfused myocardiumMyocardial perfusionLeft ventricleIntravenous tissue-type plasminogen activatorRegional wall motion scoreIntravenous thrombolytic therapyWall motion scoreTime of administrationEffect of treatmentSingle photon emissionTissue-type plasminogen activatorEjection fractionAnterior infarctsHypoperfused regionsInferior infarctsSimilar injectionsIntravenous injectionMotion scoreInfarctionMyocardial areaInfarct segmentsSerial quantitative planar technetium-99m isonitrile imaging in acute myocardial infarction: Efficacy for noninvasive assessment of thrombolytic therapy
Wackers F, Gibbons R, Verani M, Kayden D, Pellikka P, Behrenbeck T, Mahmarian J, Zaret B. Serial quantitative planar technetium-99m isonitrile imaging in acute myocardial infarction: Efficacy for noninvasive assessment of thrombolytic therapy. Journal Of The American College Of Cardiology 1989, 14: 861-873. PMID: 2507612, DOI: 10.1016/0735-1097(89)90456-7.Peer-Reviewed Original ResearchConceptsRecombinant tissue-type plasminogen activatorAcute myocardial infarctionPatent infarct-related arteryInfarct-related arteryThallium-201 imagingThrombolytic therapyMyocardial infarctionPlanar technetiumMyocardial perfusionExercise thallium-201 imagingFirst acute myocardial infarctionInfarct-related artery patencyInitial risk areaPersistent coronary occlusionSuccess of reperfusionMyocardial blood flowNew myocardial perfusionTissue-type plasminogen activatorArtery patencyChest painCoronary occlusionRepeat imagingBlood flowInfarctionThallium-201The Role of Nuclear Cardiology in the Assessment of Myocardial Infarction and the Evaluation of Early Interventions
Kayden D, Wackers F, Zaret B. The Role of Nuclear Cardiology in the Assessment of Myocardial Infarction and the Evaluation of Early Interventions. Developments In Cardiovascular Medicine 1989, 97: 187-211. DOI: 10.1007/978-1-4613-1597-1_10.Peer-Reviewed Original ResearchCoronary artery diseaseArtery diseaseConvalescent phaseMyocardial infarctionStable coronary artery diseaseManagement of patientsPresence of ischemiaMyocardial functional reserveNuclear cardiologyEarly reperfusionAcute phaseVentricular functionIschemic myocardiumMyocardial damageFunctional reservePatient prognosisEarly interventionInfarctionMyocardiumPrognosisInfarctsFuture riskPatientsDiagnostic toolAppropriate management strategies
1988
Demonstration of reperfusion after thrombolysis with technetium-99m isonitrile myocardial imaging.
Kayden D, Mattera J, Zaret B, Wackers F. Demonstration of reperfusion after thrombolysis with technetium-99m isonitrile myocardial imaging. Journal Of Nuclear Medicine 1988, 29: 1865-7. PMID: 2972815.Peer-Reviewed Original ResearchConceptsThrombolytic therapyMyocardial infarctionRecombinant tissue plasminogen activatorAcute anteroseptal myocardial infarctionSuccess of reperfusionSalvage of myocardiumAcute myocardial infarctionAnteroseptal myocardial infarctionMyocardial perfusion defectsMyocardial perfusion imagingTissue plasminogen activatorEmergency roomRepeat injectionsPerfusion defectsIntravenous injectionMyocardial imagingPerfusion imagingMyocardial redistributionInfarctionNoninvasive meansPlasminogen activatorReperfusionImaging agentTherapyTechnetiumThe Role of Nuclear Cardiology in Assessment of Acute Myocardial Infarction
den D, Wackers F, Zaret B. The Role of Nuclear Cardiology in Assessment of Acute Myocardial Infarction. Cardiology Clinics 1988, 6: 81-95. PMID: 3048676, DOI: 10.1016/s0733-8651(18)30503-4.Peer-Reviewed Original ResearchConceptsConvalescent phaseVentricular functionExercise-induced ischemiaAcute myocardial infarctionSalvaged myocardiumThallium imagingThrombolytic therapyAcute interventionIschemic myocardiumMyocardial infarctionPrognostic informationFurther interventionMyocardial perfusionPerfusion imagingAmbulatory monitoringMetabolic imagingMyocardiumNuclear cardiologyAppropriate management strategiesInterventionImagingInfarctionIschemiaPatientsTherapy
1987
Right ventricular myocardial infarction with anterior wall left ventricular infarction: An autopsy study
Cabin H, Clubb K, Wackers F, Zaret B. Right ventricular myocardial infarction with anterior wall left ventricular infarction: An autopsy study. American Heart Journal 1987, 113: 16-23. PMID: 3799430, DOI: 10.1016/0002-8703(87)90004-4.Peer-Reviewed Original ResearchConceptsRight ventricular myocardial infarctionVentricular myocardial infarctionAnterior myocardial infarctionMyocardial infarctionVentricular infarctionVentricular free wallRadionuclide angiographyVentricular infarctAnterior wallFree wallInferior left ventricular infarctionRight ventricular free wallRight ventricular dysfunctionRight ventricular infarctRight ventricular necrosisLeft ventricular infarctionLeft ventricular free wallEquilibrium radionuclide angiographyVentricular necrosisVentricular dysfunctionAutopsy studyGlobal dysfunctionInfarctionTherapeutic implicationsClinical importance
1986
Use of the Initial Electrocardiogram to Predict In-Hospital Complications of Acute Myocardial Infarction
BRUSH J, BRAND D, ACAMPORA D, CHALMER B, WACKERS F. Use of the Initial Electrocardiogram to Predict In-Hospital Complications of Acute Myocardial Infarction. Survey Of Anesthesiology 1986, 30: 29. DOI: 10.1097/00132586-198602000-00026.Peer-Reviewed Original Research
1985
Use of the Initial Electrocardiogram to Predict In-Hospital Complications of Acute Myocardial Infarction
Brush J, Brand D, Acampora D, Chalmer B, Wackers F. Use of the Initial Electrocardiogram to Predict In-Hospital Complications of Acute Myocardial Infarction. New England Journal Of Medicine 1985, 312: 1137-1141. PMID: 3920520, DOI: 10.1056/nejm198505023121801.Peer-Reviewed Original ResearchConceptsLife-threatening complicationsCoronary care unitAcute myocardial infarctionInitial electrocardiogramCare unitMyocardial infarctionPositive electrocardiogramIn-Hospital ComplicationsNegative initial electrocardiogramPredictors of complicationsIntermediate care unitEvidence of infarctionBundle branch blockVentricular hypertrophyNegative electrocardiogramHospital costsComplicationsPatientsPatient careInfarctionElectrocardiogramLower likelihoodIschemiaAdmissionHypertrophyRadionuclide Techniques for Diagnosing and Sizing of Myocardial Infarction
Wackers F. Radionuclide Techniques for Diagnosing and Sizing of Myocardial Infarction. 1985, 179-187. DOI: 10.1007/978-1-4613-3828-4_20.Peer-Reviewed Original ResearchRadionuclide techniquesAcute ischemic heart diseaseEvaluation of patientsIschemic heart diseaseAssessment of rightIll patientsVentricular functionMyocardial infarctionHeart diseaseLittle discomfortMyocardial imagingNew radiotracersPatient's bedsidePatientsNon-invasive natureNuclear cardiologyBedsideInfarctionDiseaseCardiology
1981
Imaging the inflammatory response to acute myocardial infarction in man using indium-111-labeled autologous platelets.
Davies R, Thakur M, Berger H, Wackers F, Gottschalk A, Zaret B. Imaging the inflammatory response to acute myocardial infarction in man using indium-111-labeled autologous platelets. Circulation 1981, 63: 826-832. PMID: 7471338, DOI: 10.1161/01.cir.63.4.826.Peer-Reviewed Original ResearchConceptsMyocardial infarctionInflammatory responseIndium-111-labeled autologous plateletsMembrane-active antiarrhythmic drugsPeak serum creatine kinaseStable coronary artery diseaseAcute transmural myocardial infarctionPeripheral leukocyte countCoronary artery diseaseAcute myocardial infarctionHours of infarctionTransmural myocardial infarctionIncidence of pericarditisLocation of infarctionIndium-111 leukocytesSerum creatine kinaseChest painArtery diseaseAntiarrhythmic drugsAcute infarctionAutologous leukocytesLeukocyte countAntiinflammatory drugsAutologous plateletsInfarction