2009
Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes†
Aiba T, Hesketh GG, Liu T, Carlisle R, Villa-Abrille MC, O'Rourke B, Akar FG, Tomaselli GF. Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes†. Cardiovascular Research 2009, 85: 454-463. PMID: 19797425, PMCID: PMC2802203, DOI: 10.1093/cvr/cvp324.Peer-Reviewed Original ResearchConceptsAutocamtide-2-related inhibitory peptideDependent protein kinase IIProtein kinase IIKinase IIChannel gatingGlutathione S-transferase fusion peptidesCAMP-dependent proteinIQ-like motifSpecific CaMKII inhibitorC-terminusChannel regulationPresence of CaMInactivation phenotypeCaMKIICaMKII inhibitorFusion peptideInactivationSlow inactivationFraction of channelsDistinct effectsInhibitorsPeptidesInhibitory peptidesGatingCalmodulin
2007
Regulation of ion channels and arrhythmias in the ischemic heart
Akar JG, Akar FG. Regulation of ion channels and arrhythmias in the ischemic heart. Journal Of Electrocardiology 2007, 40: s37-s41. PMID: 17993326, DOI: 10.1016/j.jelectrocard.2007.05.020.Peer-Reviewed Original ResearchConceptsIschemic injuryElectrophysiological changesIschemic heart diseaseBest treatment strategyCoronary eventsReperfusion phaseVentricular arrhythmiasIschemic episodesHeart diseaseLeading causeElectrical dysfunctionTreatment strategiesIschemic heartMetabolic substratesPatientsArrhythmiasKey cellularTime courseInjuryIon channelsHeartDysfunctionMortalityDisease