2010
Optical imaging of mitochondrial function uncovers actively propagating waves of mitochondrial membrane potential collapse across intact heart
Lyon AR, Joudrey PJ, Jin D, Nass RD, Aon MA, O'Rourke B, Akar FG. Optical imaging of mitochondrial function uncovers actively propagating waves of mitochondrial membrane potential collapse across intact heart. Journal Of Molecular And Cellular Cardiology 2010, 49: 565-575. PMID: 20624394, PMCID: PMC3081287, DOI: 10.1016/j.yjmcc.2010.07.002.Peer-Reviewed Original Research
2009
From mitochondrial dynamics to arrhythmias
Aon MA, Cortassa S, Akar FG, Brown DA, Zhou L, O’Rourke B. From mitochondrial dynamics to arrhythmias. The International Journal Of Biochemistry & Cell Biology 2009, 41: 1940-1948. PMID: 19703656, PMCID: PMC2732583, DOI: 10.1016/j.biocel.2009.02.016.Peer-Reviewed Original ResearchConceptsWhole cellsMitochondrial membrane potentialMode of functionMitochondrial networkOxidative stressMitochondrial dynamicsReactive oxygen speciesMitochondrial criticalityMitochondria behaveMitochondriaCellular excitabilityOxygen speciesMembrane potentialPhysiological conditionsROSCatastrophic arrhythmiasCellsCardiac cellsEnergetic failureNormal conditionsSpeciesMessengerNADHStressBroad range
2008
A ligand to the mitochondrial benzodiazepine receptor prevents ventricular arrhythmias and LV dysfunction after ischemia or glutathione depletion
Brown D, Aon M, Akar F, O’Rourke B. A ligand to the mitochondrial benzodiazepine receptor prevents ventricular arrhythmias and LV dysfunction after ischemia or glutathione depletion. The FASEB Journal 2008, 22: 747.7-747.7. DOI: 10.1096/fasebj.22.1_supplement.747.7.Peer-Reviewed Original ResearchContractile dysfunctionBenzodiazepine receptorsGlobal ischemia/reperfusionOxidative stressMitochondrial benzodiazepine receptorIschemia/reperfusionGuinea pig heartsSignificant clinical implicationsAnti-oxidant defensesReduced arrhythmiasLV dysfunctionVentricular dysfunctionR injuryVentricular arrhythmiasInduced arrhythmiasNormoxic perfusionIsolated myocytesDysfunctionClinical implicationsArrhythmiasIntact heartMetabolic challengesPig heartsGlutathione depletionMitochondrial membrane potential
2005
Mitochondrial criticality: A new concept at the turning point of life or death
Aon MA, Cortassa S, Akar FG, O'Rourke B. Mitochondrial criticality: A new concept at the turning point of life or death. Biochimica Et Biophysica Acta 2005, 1762: 232-240. PMID: 16242921, PMCID: PMC2692535, DOI: 10.1016/j.bbadis.2005.06.008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements