Featured Publications
Perivascular Fat Attenuation Index Stratifies Cardiac Risk Associated With High-Risk Plaques in the CRISP-CT Study
Oikonomou EK, Desai MY, Marwan M, Kotanidis CP, Antonopoulos AS, Schottlander D, Channon KM, Neubauer S, Achenbach S, Antoniades C. Perivascular Fat Attenuation Index Stratifies Cardiac Risk Associated With High-Risk Plaques in the CRISP-CT Study. Journal Of The American College Of Cardiology 2020, 76: 755-757. PMID: 32762910, DOI: 10.1016/j.jacc.2020.05.078.Peer-Reviewed Original ResearchNon-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data
Oikonomou EK, Marwan M, Desai MY, Mancio J, Alashi A, Centeno E, Thomas S, Herdman L, Kotanidis CP, Thomas KE, Griffin BP, Flamm SD, Antonopoulos AS, Shirodaria C, Sabharwal N, Deanfield J, Neubauer S, Hopewell JC, Channon KM, Achenbach S, Antoniades C. Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data. The Lancet 2018, 392: 929-939. PMID: 30170852, PMCID: PMC6137540, DOI: 10.1016/s0140-6736(18)31114-0.Peer-Reviewed Original ResearchMeSH KeywordsAdipocytesAdipose TissueAdolescentAdultAgedAged, 80 and overComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCoronary VesselsFemaleFollow-Up StudiesHumansImaging, Three-DimensionalMaleMiddle AgedPlaque, AtheroscleroticPredictive Value of TestsProportional Hazards ModelsProspective StudiesRisk AssessmentSurvival AnalysisYoung AdultConceptsRight coronary arteryProximal right coronary arteryCardiac mortalityCoronary inflammationCoronary CTACoronary arteryDerivation cohortValidation cohortOutcome dataHealth Research Oxford Biomedical Research CentreCoronary artery disease indexHigh-risk plaque featuresPerivascular fat attenuation indexCoronary artery inflammationFat attenuation indexIntensive secondary preventionCardiovascular risk factorsResidual cardiovascular riskProspective outcome dataMajor coronary arteriesHounsfield unitsLeft circumflex arteryCox regression modelRisk predictionCardiac risk prediction
2021
Standardized measurement of coronary inflammation using cardiovascular computed tomography: integration in clinical care as a prognostic medical device
Oikonomou EK, Antonopoulos AS, Schottlander D, Marwan M, Mathers C, Tomlins P, Siddique M, Klüner LV, Shirodaria C, Mavrogiannis MC, Thomas S, Fava A, Deanfield J, Channon KM, Neubauer S, Desai MY, Achenbach S, Antoniades C. Standardized measurement of coronary inflammation using cardiovascular computed tomography: integration in clinical care as a prognostic medical device. Cardiovascular Research 2021, 117: 2677-2690. PMID: 34450625, DOI: 10.1093/cvr/cvab286.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAdiposityAdolescentAdultAgedAged, 80 and overAlgorithmsCloud ComputingComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseCoronary VesselsDecision Support TechniquesEnglandFemaleGermanyHeart Disease Risk FactorsHumansInflammationMaleMiddle AgedNomogramsOhioPredictive Value of TestsPrognosisRisk AssessmentTime FactorsYoung AdultConceptsFat attenuation indexPerivascular fat attenuation indexRisk factor-based modelCoronary artery inflammationClinical risk factorsFatal cardiac eventsCoronary artery diseaseCoronary inflammationRisk factorsFAI scorePlaque metricsCardiac eventsArtery inflammationAbsolute riskCoronary arteryClinical careNon-invasive detectionTraditional cardiovascular risk factorsPatient's absolute riskCardiovascular risk factorsFat compositionNet clinical benefitCardiovascular risk predictionDecision curve analysisFirst-line modality
2019
Association of Biologic Therapy With Coronary Inflammation in Patients With Psoriasis as Assessed by Perivascular Fat Attenuation Index
Elnabawi YA, Oikonomou EK, Dey AK, Mancio J, Rodante JA, Aksentijevich M, Choi H, Keel A, Erb-Alvarez J, Teague HL, Joshi AA, Playford MP, Lockshin B, Choi AD, Gelfand JM, Chen MY, Bluemke DA, Shirodaria C, Antoniades C, Mehta NN. Association of Biologic Therapy With Coronary Inflammation in Patients With Psoriasis as Assessed by Perivascular Fat Attenuation Index. JAMA Cardiology 2019, 4: 885-891. PMID: 31365032, PMCID: PMC6669789, DOI: 10.1001/jamacardio.2019.2589.Peer-Reviewed Original ResearchConceptsPerivascular fat attenuation indexFat attenuation indexBiologic psoriasis therapyBiologic therapyCoronary inflammationSevere psoriasisPsoriasis therapyCoronary plaquesSkin diseasesAnti-tumor necrosis factor αChronic inflammatory skin diseaseDifferent biologic agentsTraditional risk scoresCoronary plaque burdenLow cardiovascular riskProspective cohort studyAnti-inflammatory effectsCoronary artery diseaseInflammatory skin diseaseCoronary atherosclerotic plaquesNecrosis factor αSevere skin diseaseCardiovascular eventsCardiovascular riskCohort study
2017
Detecting human coronary inflammation by imaging perivascular fat
Antonopoulos AS, Sanna F, Sabharwal N, Thomas S, Oikonomou EK, Herdman L, Margaritis M, Shirodaria C, Kampoli AM, Akoumianakis I, Petrou M, Sayeed R, Krasopoulos G, Psarros C, Ciccone P, Brophy CM, Digby J, Kelion A, Uberoi R, Anthony S, Alexopoulos N, Tousoulis D, Achenbach S, Neubauer S, Channon KM, Antoniades C. Detecting human coronary inflammation by imaging perivascular fat. Science Translational Medicine 2017, 9 PMID: 28701474, DOI: 10.1126/scitranslmed.aal2658.Peer-Reviewed Original ResearchConceptsPerivascular adipose tissueFat attenuation indexVascular inflammationSubclinical coronary artery diseaseHuman adipose tissue explantsHuman vesselsLipid accumulationHuman coronary vasculatureAcute coronary syndromeCoronary artery diseaseVulnerable atherosclerotic plaquesIntracellular lipid accumulationHuman coronary arteriesAdipocyte lipid contentAdipose tissue explantsPositron emission tomographyCT scan informationCoronary inflammationCoronary syndromeArtery diseaseCardiac surgeryValidation cohortCoronary arteryMultiple disease statesTissue inflammationA prospective study of external stenting of saphenous vein grafts to the right coronary artery: the VEST II study
Taggart DP, Amin S, Djordjevic J, Oikonomou EK, Thomas S, Kampoli AM, Sabharwal N, Antoniades C, Krasopoulos G. A prospective study of external stenting of saphenous vein grafts to the right coronary artery: the VEST II study. European Journal Of Cardio-Thoracic Surgery 2017, 51: 952-958. PMID: 28379404, DOI: 10.1093/ejcts/ezw438.Peer-Reviewed Original ResearchConceptsRight coronary arteryComputed tomography angiographyCoronary arteryExternal stentRight internal mammary artery graftInternal mammary artery graftLeft internal mammary arteryGraft 1 yearMammary artery graftsRight coronary territoryCoronary artery bypassEnd of surgeryInternal mammary arterySaphenous vein graftsSide branchesLeft territoryRight territorySVG patencyArtery bypassArtery graftExternal stentingMammary arteryPrimary endpointGraft failureII study