Featured Publications
Individualising intensive systolic blood pressure reduction in hypertension using computational trial phenomaps and machine learning: a post-hoc analysis of randomised clinical trials
Oikonomou EK, Spatz ES, Suchard MA, Khera R. Individualising intensive systolic blood pressure reduction in hypertension using computational trial phenomaps and machine learning: a post-hoc analysis of randomised clinical trials. The Lancet Digital Health 2022, 4: e796-e805. PMID: 36307193, PMCID: PMC9768739, DOI: 10.1016/s2589-7500(22)00170-4.Peer-Reviewed Original ResearchConceptsSystolic blood pressure controlBlood pressure controlIntensive systolic blood pressure controlType 2 diabetesPressure controlCardiovascular benefitsClinical trialsMajor adverse cardiovascular eventsFirst major adverse cardiovascular eventLarge randomised clinical trialsACCORD-BP trialAdverse cardiovascular eventsRandomised clinical trialsSystolic blood pressureCox regression analysisTreatment effectsHazard ratio estimatesACCORD-BPBP trialCardiovascular eventsBlood pressurePrimary outcomeStandard treatmentBaseline variablesIndex patients
2018
The predictive value of baseline pulmonary hypertension in early and long term cardiac and all-cause mortality after transcatheter aortic valve implantation for patients with severe aortic valve stenosis: A systematic review and meta-analysis
Kokkinidis DG, Papanastasiou CA, Jonnalagadda AK, Oikonomou EK, Theochari CA, Palaiodimos L, Karvounis HI, Armstrong EJ, Faillace RT, Giannakoulas G. The predictive value of baseline pulmonary hypertension in early and long term cardiac and all-cause mortality after transcatheter aortic valve implantation for patients with severe aortic valve stenosis: A systematic review and meta-analysis. Cardiovascular Revascularization Medicine 2018, 19: 859-867. PMID: 29724516, DOI: 10.1016/j.carrev.2018.03.015.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationElevated pulmonary artery pressurePulmonary artery pressureAortic valve stenosisSevere aortic valve stenosisSurgical aortic valve replacementBaseline pulmonary hypertensionPulmonary hypertensionAortic valve implantationArtery pressureCause mortalityHazard ratioSystematic reviewValve implantationValve stenosisRelative riskAssociation of PHBaseline pulmonary artery pressurePulmonary artery systolic pressureChronic obstructive pulmonary diseaseAortic valve replacementLate cardiac mortalityObstructive pulmonary diseaseRandom-effects modelMeta-regression analysis
2017
Clinical and translational science in cardiovascular research: highlights from the American Heart Association Scientific Sessions 2017
Oikonomou EK. Clinical and translational science in cardiovascular research: highlights from the American Heart Association Scientific Sessions 2017. Cardiovascular Research 2017, 114: e6-e8. PMID: 29202178, DOI: 10.1093/cvr/cvx233.Commentaries, Editorials and LettersEfficacy of ganglionated plexi ablation in addition to pulmonary vein isolation for paroxysmal versus persistent atrial fibrillation: a meta-analysis of randomized controlled clinical trials
Kampaktsis PN, Oikonomou EK, Y. Choi D, Cheung JW. Efficacy of ganglionated plexi ablation in addition to pulmonary vein isolation for paroxysmal versus persistent atrial fibrillation: a meta-analysis of randomized controlled clinical trials. Journal Of Interventional Cardiac Electrophysiology 2017, 50: 253-260. PMID: 28887742, DOI: 10.1007/s10840-017-0285-z.Peer-Reviewed Original ResearchConceptsPulmonary vein isolationAT/AFGP ablationAtrial fibrillationPV isolationVein isolationPlexi ablationAF patientsAtrial tachyarrhythmiasSubtype of AFSignificant structural heart diseaseParoxysmal AF patientsVentricular ejection fractionParoxysmal atrial fibrillationPersistent atrial fibrillationStructural heart diseaseSustained atrial fibrillationPersistent AF patientsClinical trial dataNon-significant trendPrimary endpointAF subtypesAtrial sizeEjection fractionHeart diseaseRole of deferred stenting in patients with ST elevation myocardial infarction treated with primary percutaneous coronary intervention: A systematic review and meta‐analysis
De Maria GL, Alkhalil M, Oikonomou EK, Wolfrum M, Choudhury RP, Banning AP. Role of deferred stenting in patients with ST elevation myocardial infarction treated with primary percutaneous coronary intervention: A systematic review and meta‐analysis. Journal Of Interventional Cardiology 2017, 30: 264-273. PMID: 28370496, DOI: 10.1111/joic.12380.Peer-Reviewed Original ResearchConceptsPrimary percutaneous coronary interventionHard clinical endpointsImmediate stentingAngiographic endpointsClinical endpointsST-elevation myocardial infarctionElevation myocardial infarctionPercutaneous coronary interventionRandomized clinical trialsCoronary interventionMyocardial infarctionClinical trialsImproved outcomesElectronic databasesFlow restorationPatientsEndpointStentingSTEMIInfarctionRecent publicationsTrials
2016
Prognostic implications of epicardial fat volume quantification in acute pericarditis
Lazaros G, Antonopoulos AS, Oikonomou EK, Vasileiou P, Oikonomou E, Stroumpouli E, Karavidas A, Antoniades C, Tousoulis D. Prognostic implications of epicardial fat volume quantification in acute pericarditis. European Journal Of Clinical Investigation 2016, 47: 129-136. PMID: 27931089, DOI: 10.1111/eci.12711.Peer-Reviewed Original ResearchConceptsEpicardial fat volumeCardiac computerized tomographyComposite clinical endpointAcute pericarditisIncessant pericarditisChest painPrognostic implicationsClinical endpointsPoor responsePericardial effusion sizeOutcomes of patientsAtrial fibrillation developmentImportant prognostic implicationsCardiovascular disease pathogenesisAnti-inflammatory drugsLower odds ratioFifty patientsClinical featuresEffusion sizeFirst diagnosisPrognostic informationOdds ratioPericarditisFat volumePatients