2019
High-Density Lipoprotein Particle Subfractions in Heart Failure With Preserved or Reduced Ejection Fraction
Hunter WG, McGarrah RW, Kelly JP, Khouri MG, Craig DM, Haynes C, Felker GM, Hernandez AF, Velazquez EJ, Kraus WE, Shah SH. High-Density Lipoprotein Particle Subfractions in Heart Failure With Preserved or Reduced Ejection Fraction. Journal Of The American College Of Cardiology 2019, 73: 177-186. PMID: 30654890, DOI: 10.1016/j.jacc.2018.10.059.Peer-Reviewed Original ResearchConceptsLipoprotein particle subfractionsHeart failureEjection fractionTotal HDLSmall HDLMajor adverse cardiac eventsVentricular end-diastolic pressureHDL-P sizeAdverse cardiac eventsReduced ejection fractionEnd-diastolic pressureCox proportional hazardsStrict inclusion criteriaCATHGEN biorepositoryDiastolic dysfunctionAdverse eventsCardiac eventsSequential patientsCardiac catheterizationEndothelial functionMultivariable analysisPrognostic utilityAdverse outcomesClinical covariatesHFpEF
2016
Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure
Hunter WG, Kelly JP, McGarrah RW, Khouri MG, Craig D, Haynes C, Ilkayeva O, Stevens RD, Bain JR, Muehlbauer MJ, Newgard CB, Felker GM, Hernandez AF, Velazquez EJ, Kraus WE, Shah SH. Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure. Journal Of The American Heart Association 2016, 5: e003190. PMID: 27473038, PMCID: PMC5015273, DOI: 10.1161/jaha.115.003190.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionReduced ejection fractionEjection fractionHF controlsHFpEF casesHeart failureMetabolic impairmentVersus Reduced Ejection FractionHistory of HFNormal diastolic functionNovel circulating biomarkersClinical heart failureVentricular ejection fractionDiastolic dysfunction gradeHeart failure pathogenesisStrict inclusion criteriaFatty acid oxidationLVEF spectrumCardiac catheterizationDiastolic functionHF diagnosisSequential patientsMetabolic abnormalitiesInsulin resistanceCirculating Biomarkers