2019
Gender Differences in Outcomes After Implantation of Left Ventricular Assist Devices
Ahmed A, Adegbala O, Akintoye E, Inampudi C, Ajam M, Yassin A, Olawusi E, Shokr M, Alvarez P, Briasoulis A. Gender Differences in Outcomes After Implantation of Left Ventricular Assist Devices. The Annals Of Thoracic Surgery 2019, 109: 780-786. PMID: 31479642, DOI: 10.1016/j.athoracsur.2019.07.032.Peer-Reviewed Original ResearchConceptsLVAD implantationContinuous-flow LVADVentricular assist device implantationLeft ventricular assist deviceAcute kidney injuryAssist device implantationMost common complicationsExtracorporeal membrane oxygenationMedian hospitalization costNational Inpatient SamplePostoperative cardiac tamponadeLength of stayYears of ageVentricular assist deviceGender-specific differencesHospital mortalityPostoperative thromboembolismCardiac tamponadeHospital outcomesKidney injuryPeriprocedural complicationsPostoperative sepsisCommon complicationInpatient mortalityLVAD placementOptimum age for performing Fontan operation in patients with univentricular heart
Akintoye E, Veldtman G, Miranda W, Connolly H, Egbe A. Optimum age for performing Fontan operation in patients with univentricular heart. Congenital Heart Disease 2019, 14: 138-139. PMID: 30945806, DOI: 10.1111/chd.12690.Peer-Reviewed Original ResearchTrends and Outcomes of Infective Endocarditis in Adults With Tetralogy of Fallot: A Review of the National Inpatient Sample Database
Egbe A, Vallabhajosyula S, Akintoye E, Connolly H. Trends and Outcomes of Infective Endocarditis in Adults With Tetralogy of Fallot: A Review of the National Inpatient Sample Database. Canadian Journal Of Cardiology 2019, 35: 721-726. PMID: 31151707, DOI: 10.1016/j.cjca.2019.02.006.Peer-Reviewed Original ResearchConceptsHealth care resource utilizationTetralogy of FallotProsthetic valve implantationNational Inpatient SampleCongenital heart diseaseHospital mortalityValve implantationInfective endocarditisHeart diseaseRisk factorsTOF patientsInflation-adjusted hospitalization costsNational Inpatient Sample databaseCyanotic congenital heart diseaseIncidence of endocarditisLength of stayPacemaker/defibrillatorLow socioeconomic classPopulation-based riskHospital dischargeSecondary outcomesPrimary outcomeHospitalization costsBlack raceInpatient SampleImpact of atrial fibrillation on patients hospitalized for acute myocarditis: Insights from a nationally‐representative United States cohort
Subahi A, Akintoye E, Yassin A, Abubakar H, Adegbala O, Mishra T, Abdelrahman M, Shokr M, Afonso L. Impact of atrial fibrillation on patients hospitalized for acute myocarditis: Insights from a nationally‐representative United States cohort. Clinical Cardiology 2019, 42: 26-31. PMID: 30284301, PMCID: PMC6436524, DOI: 10.1002/clc.23088.Peer-Reviewed Original ResearchConceptsAtrial fibrillationHospital mortalityHospital outcomesAcute myocarditisICD-9-CM diagnostic codesNon-routine hospital dischargeImpact of AFPropensity score-matched control groupAcute myocarditis patientsAcute kidney injuryUnited States cohortNational Inpatient SampleCardiac tamponadeCardiogenic shockCause mortalityKidney injuryMyocarditis patientsAM patientsHospital dischargeAF groupInpatient SamplePrimary diagnosisDiagnostic codesHigh riskGeneral population
2018
Effect of Hospital Ownership on Outcomes After Left Ventricular Assist Device Implantation in the United States
Briasoulis A, Inampudi C, Akintoye E, Adegbala O, Bhama J, Alvarez P. Effect of Hospital Ownership on Outcomes After Left Ventricular Assist Device Implantation in the United States. The Annals Of Thoracic Surgery 2018, 107: 527-532. PMID: 30316859, DOI: 10.1016/j.athoracsur.2018.08.051.Peer-Reviewed Original ResearchOutcomes and Effects of Hepatic Cirrhosis in Patients Who Underwent Transcatheter Aortic Valve Implantation
Yassin A, Subahi A, Abubakar H, Akintoye E, Alhusain R, Adegbala O, Ahmed A, Elmoughrabi A, Subahi E, Pahuja M, Sahlieh A, Elder M, Kaki A, Schreiber T, Mohamad T. Outcomes and Effects of Hepatic Cirrhosis in Patients Who Underwent Transcatheter Aortic Valve Implantation. The American Journal Of Cardiology 2018, 122: 455-460. PMID: 30041889, DOI: 10.1016/j.amjcard.2018.04.013.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationAortic valve implantationLiver cirrhosisCirrhotic patientsValve implantationUnderwent Transcatheter Aortic Valve ImplantationNational Inpatient Sample databasePropensity score-matched analysisNonroutine hospital dischargeSevere aortic stenosisAortic valve replacementReasonable therapeutic optionCost of hospitalizationHospital mortalityHospital stayVascular complicationsHospital dischargeInpatient mortalitySecondary outcomesValve replacementAortic stenosisPacemaker implantationPrimary outcomeProcedural complicationsClinical outcomesClinical End Points of Transcatheter Aortic Valve Implantation Compared With Surgical Aortic Valve Replacement in Patients <65 Years of Age (From the National Inpatient Sample Database)
Ando T, Akintoye E, Holmes A, Briasoulis A, Pahuja M, Takagi H, Schreiber T, Grines C, Afonso L. Clinical End Points of Transcatheter Aortic Valve Implantation Compared With Surgical Aortic Valve Replacement in Patients <65 Years of Age (From the National Inpatient Sample Database). The American Journal Of Cardiology 2018, 122: 279-283. PMID: 29880287, DOI: 10.1016/j.amjcard.2018.03.356.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAortic ValveAortic Valve StenosisCause of DeathFemaleFollow-Up StudiesHospital MortalityHumansIncidenceInpatientsLength of StayMaleMiddle AgedPostoperative ComplicationsPropensity ScoreRegistriesRetrospective StudiesRisk AssessmentRisk FactorsSurvival RateTime FactorsTranscatheter Aortic Valve ReplacementUnited StatesYoung AdultConceptsSurgical aortic valve replacementTranscatheter aortic valve implantationAortic valve replacementShorter hospital stayAortic valve implantationHospital mortalityHospital stayValve replacementValve implantationNational Inpatient Sample databaseSafe alternativeAcute kidney injuryOlder patient populationClinical end pointsAcute myocardial infarctionPropensity score analysisYears of agePostprocedure strokeKidney injuryValve surgeryVascular complicationsMajor complicationsPacemaker implantationPatient populationMyocardial infarctionSafety and Efficacy of Novel Oral Anticoagulants Versus Warfarin in Medicare Beneficiaries With Atrial Fibrillation and Valvular Heart Disease
Briasoulis A, Inampudi C, Akintoye E, Alvarez P, Panaich S, Vaughan‐Sarrazin M. Safety and Efficacy of Novel Oral Anticoagulants Versus Warfarin in Medicare Beneficiaries With Atrial Fibrillation and Valvular Heart Disease. Journal Of The American Heart Association 2018, 7: e008773. PMID: 29622591, PMCID: PMC6015407, DOI: 10.1161/jaha.118.008773.Peer-Reviewed Original ResearchConceptsValvular heart diseaseAtrial fibrillationMedicare beneficiariesIschemic strokeHeart diseaseNew-onset atrial fibrillationNon-vitamin K anticoagulantsGastrointestinal bleeding ratesLarge community-based samplePropensity-matched sampleCommunity-based sampleMajor bleedingNongastrointestinal bleedingCause mortalitySystemic thromboembolismVersus WarfarinPrimary outcomePropensity matchingMyocardial infarctionBleeding rateLower riskPatientsRivaroxabanWarfarinDabigatranRelation of Cannabis Use and Atrial Fibrillation Among Patients Hospitalized for Heart Failure
Adegbala O, Adejumo A, Olakanmi O, Akinjero A, Akintoye E, Alliu S, Edo-Osagie E, Chatterjee A. Relation of Cannabis Use and Atrial Fibrillation Among Patients Hospitalized for Heart Failure. The American Journal Of Cardiology 2018, 122: 129-134. PMID: 29685570, DOI: 10.1016/j.amjcard.2018.03.015.Peer-Reviewed Original ResearchConceptsDiagnosis of HFAtrial fibrillationHeart failureNervous systemCannabis usersOccurrence of AFUtilization Project National Inpatient SampleDiagnosis of AFCannabis useLeft ventricular dysfunctionCo-morbid conditionsSympathetic nervous systemCannabis user groupAutonomic nervous systemInotropic supportVentricular dysfunctionCardiovascular effectsSympathetic effectsSympathetic activityAutonomic effectsInpatient SampleAF diagnosisInsurance typeMain exposureLower odds
2017
Mechanism for temporal changes in exercise capacity after Fontan palliation: Role of Doppler echocardiography
Egbe A, Khan A, Miranda W, Ammash N, Warnes C, Said S, Taggart N, Akintoye E, Veldtman G, Connolly H. Mechanism for temporal changes in exercise capacity after Fontan palliation: Role of Doppler echocardiography. American Heart Journal 2017, 196: 144-152. PMID: 29421006, DOI: 10.1016/j.ahj.2017.10.010.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdultAge FactorsCohort StudiesDouble Outlet Right VentricleEchocardiography, DopplerExercise TestExercise ToleranceFollow-Up StudiesFontan ProcedureHeart Defects, CongenitalHumansMaleMichiganOxygen ConsumptionPulmonary AtresiaRetrospective StudiesTime FactorsTreatment OutcomeTricuspid AtresiaYoung AdultConceptsCardiopulmonary exercise testTransthoracic echocardiogramLV function indicesFontan palliationExercise capacityChronotropic indexFunction IndexLeft ventricleAdult Fontan patientsFontan conversion operationSystemic left ventriclePeak oxygen consumptionSerial transthoracic echocardiogramsFontan patientsFontan conversionDoppler echocardiographyRetrospective reviewDoppler hemodynamicsMean ageHemodynamic mechanismsExercise testMayo ClinicCPET dataPatientsTemporal improvementOutcomes of cardiac pacing in adult patients after a Fontan operation
Egbe A, Huntley G, Connolly H, Ammash N, Deshmukh A, Khan A, Said S, Akintoye E, Warnes C, Kapa S. Outcomes of cardiac pacing in adult patients after a Fontan operation. American Heart Journal 2017, 194: 92-98. PMID: 29223440, DOI: 10.1016/j.ahj.2017.08.019.Peer-Reviewed Original ResearchConceptsDevice-related complicationsCardiovascular adverse eventsAdult Fontan patientsFontan patientsEndocardial leadsFontan operationPacemaker implantationRisk factorsEpicardial leadsCardiac pacingLead failureDevice-related infectionsReintervention rateAdult patientsAdverse eventsHeart transplantRetrospective reviewVenous thrombosisCardiac perforationMayo ClinicReinterventionPatientsLead recallDual chamberPacingBiochemical risk markers and 10-year incidence of atherosclerotic cardiovascular disease: independent predictors, improvement in pooled cohort equation, and risk reclassification
Akintoye E, Briasoulis A, Afonso L. Biochemical risk markers and 10-year incidence of atherosclerotic cardiovascular disease: independent predictors, improvement in pooled cohort equation, and risk reclassification. American Heart Journal 2017, 193: 95-103. PMID: 29129262, DOI: 10.1016/j.ahj.2017.08.002.Peer-Reviewed Original ResearchConceptsPooled Cohort EquationsNet reclassification indexBiochemical risk markersBiomarker scoreCohort EquationsC-statisticRisk markersTreatment decisionsPrimary atherosclerotic cardiovascular disease (ASCVD) preventionAtherosclerotic cardiovascular disease preventionCategorical net reclassification indexSensitivity C-reactive proteinCategory-free net reclassification indexN-terminal prohormoneBrain natriuretic peptideAtherosclerotic cardiovascular diseaseCardiovascular disease preventionC-reactive proteinMulti-Ethnic StudyRate of incidentsASCVD preventionIndependent predictorsNet reclassificationNatriuretic peptideRisk reclassificationComparison of In-Hospital Outcomes of Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement in Obese (Body Mass Index ≥ 30 Kg/M2) Patients
Ando T, Akintoye E, Trehan N, Telila T, Briasoulis A, Takagi H, Grines C, Afonso L. Comparison of In-Hospital Outcomes of Transcatheter Aortic Valve Implantation Versus Surgical Aortic Valve Replacement in Obese (Body Mass Index ≥ 30 Kg/M2) Patients. The American Journal Of Cardiology 2017, 120: 1858-1862. PMID: 28860018, DOI: 10.1016/j.amjcard.2017.07.098.Peer-Reviewed Original ResearchMeSH KeywordsAgedAortic ValveAortic Valve StenosisBody Mass IndexComorbidityFemaleFollow-Up StudiesHospital MortalityHumansIncidenceInpatientsMaleObesityPostoperative ComplicationsPrevalencePrognosisPropensity ScoreRisk AssessmentRisk FactorsSurvival RateTime FactorsTranscatheter Aortic Valve ReplacementUnited StatesConceptsTranscatheter aortic valve implantationSurgical aortic valve replacementAortic valve replacementTAVI patientsNonroutine dischargeObese patientsValve replacementTranscatheter Aortic Valve Implantation Versus Surgical Aortic Valve ReplacementNationwide Inpatient Sample databaseHigher co-morbidity burdenCertain perioperative complicationsAcute kidney injuryIn-Hospital OutcomesShorter hospital stayAortic valve implantationCo-morbidity burdenMedian hospital costsAcute myocardial infarctionLength of stayCharlson scoreDeyo's modificationHospital mortalityCardiac complicationsHospital stayKidney injuryPrevalence and predictors of intracranial aneurysms in patients with bicuspid aortic valve
Egbe A, Padang R, Brown R, Khan A, Luis S, Huston J, Akintoye E, Connolly H. Prevalence and predictors of intracranial aneurysms in patients with bicuspid aortic valve. Heart 2017, 103: 1508. PMID: 28596303, DOI: 10.1136/heartjnl-2016-311076.Peer-Reviewed Original ResearchMeSH KeywordsAge DistributionAgedAged, 80 and overAortic ValveBicuspid Aortic Valve DiseaseBrainEchocardiographyFemaleFollow-Up StudiesForecastingHeart Valve DiseasesHumansIntracranial AneurysmMagnetic Resonance AngiographyMaleMiddle AgedMinnesotaPrevalenceRetrospective StudiesRisk FactorsSex DistributionConceptsCoarctation of aortaBicuspid aortic valveLeft cusp fusionIntracranial aneurysmsCusp fusionAortic valveFemale genderBrain MR angiographyStudy mean ageAge tertilesRetrospective reviewCoil embolisationRisk factorsMayo ClinicHigh prevalenceAge 41General populationPatientsMR angiographyPrevalenceAneurysmsAgeRiskYearsEmbolisationUsefulness of the Mitral Regurgitation Severity Index to Assess the Severity of Chronic Mitral Regurgitation
Afonso L, Shokr M, Akintoye E, Briasoulis A, Alesh I, Alani A, Mahajan N, Veeranna V, Mostafa A, Zmily H, Telila T, Zalawadiya S. Usefulness of the Mitral Regurgitation Severity Index to Assess the Severity of Chronic Mitral Regurgitation. The American Journal Of Cardiology 2017, 120: 304-308. PMID: 28550931, DOI: 10.1016/j.amjcard.2017.04.027.Peer-Reviewed Original ResearchMeSH KeywordsBlood Flow VelocityChronic DiseaseEchocardiography, Doppler, ColorEchocardiography, TransesophagealFemaleFollow-Up StudiesHumansMaleMiddle AgedMitral ValveMitral Valve InsufficiencyPredictive Value of TestsReproducibility of ResultsRetrospective StudiesROC CurveSeverity of Illness IndexConceptsSevere mitral regurgitationMitral regurgitationTime-velocity integralVelocity integralNonsevere mitral regurgitationChronic mitral regurgitationInter-rater reproducibilityOptimal diagnostic accuracyDerivation cohortMitral inflowValidation cohortGood inter-rater reproducibilityHigh interobserver variabilityMR severityInter-rater agreementLevel IIMean differenceDiagnostic accuracyInterobserver variabilitySeverity IndexCut pointsRegurgitationPatientsCohortSeverityCardiopulmonary exercise test in adults with prior Fontan operation: The prognostic value of serial testing
Egbe A, Driscoll D, Khan A, Said S, Akintoye E, Berganza F, Connolly H. Cardiopulmonary exercise test in adults with prior Fontan operation: The prognostic value of serial testing. International Journal Of Cardiology 2017, 235: 6-10. PMID: 28284501, DOI: 10.1016/j.ijcard.2017.02.140.Peer-Reviewed Original ResearchConceptsSerial cardiopulmonary exercise testsCardiovascular adverse eventsCardiopulmonary exercise testPercentage points/yearPoints/yearFontan operationPeak VOExercise testBaseline cardiopulmonary exercise testBaseline peak oxygen consumptionAdult Fontan patientsAdult Fontan populationPrior Fontan operationPeak oxygen consumptionPeak heart rateFontan populationFontan palliationFontan patientsPeak exerciseAdverse eventsCardiac surgeryRetrospective reviewPrognostic valueInclusion criteriaSerial testing