2023
Impact of Age and Sex on Left Ventricular Remodeling in Patients With Aortic Regurgitation
Akintoye E, Saijo Y, Braghieri L, Badwan O, Patel H, Dabbagh M, El Dahdah J, Jellis C, Desai M, Rodriguez L, Grimm R, Griffin B, Popović Z. Impact of Age and Sex on Left Ventricular Remodeling in Patients With Aortic Regurgitation. Journal Of The American College Of Cardiology 2023, 81: 1474-1487. PMID: 37045517, DOI: 10.1016/j.jacc.2023.02.037.Peer-Reviewed Original ResearchConceptsSmaller LV volumesAdverse eventsAortic regurgitationBody surface areaOlder patientsYounger patientsLV volumesImpact of ageLV remodelingSerial evaluationLV end-systolic volumeLV end-diastolic volumeSevere aortic regurgitationChronic aortic regurgitationLeft ventricular remodelingEnd-diastolic volumeEnd-systolic volumeLower LV volumesAdult patientsConsecutive patientsMain endpointVentricular dimensionsVentricular remodelingCurrent guidelinesPatientsLeft Ventricular Global Longitudinal Strain Before TAVR Time to Jump the Ejection Fraction Ship? ∗
Desai M, Akintoye E. Left Ventricular Global Longitudinal Strain Before TAVR Time to Jump the Ejection Fraction Ship? ∗. JACC Cardiovascular Imaging 2023, 16: 342-344. PMID: 36889850, DOI: 10.1016/j.jcmg.2023.01.011.Peer-Reviewed Original Research
2022
Quantitative Echocardiographic Assessment and Optimal Criteria for Early Intervention in Asymptomatic Tricuspid Regurgitation
Akintoye E, Wang T, Nakhla M, Ali A, Fava A, Akyuz K, Popovic Z, Pettersson G, Gillinov A, Xu B, Griffin B, Desai M. Quantitative Echocardiographic Assessment and Optimal Criteria for Early Intervention in Asymptomatic Tricuspid Regurgitation. JACC Cardiovascular Imaging 2022, 16: 13-24. PMID: 36274042, DOI: 10.1016/j.jcmg.2022.08.004.Peer-Reviewed Original ResearchMeSH KeywordsAgedEchocardiographyFemaleHumansMalePredictive Value of TestsRetrospective StudiesSeverity of Illness IndexTricuspid ValveTricuspid Valve InsufficiencyConceptsTricuspid regurgitationMedian survival timeRisk factorsAsymptomatic patientsEchocardiographic parametersSurvival timeEarly interventionOptimal timingRight heart parametersSymptomatic tricuspid regurgitationSignificant tricuspid regurgitationFree wall strainHigh operative mortalitySex-matched cohortQuantitative echocardiographic assessmentKey prognostic markersCause mortalityOperative mortalityTR patientsEchocardiographic assessmentLate presentationPoor outcomePrognostic utilityPrognostic valuePrognostic markerTrends and Outcomes of Patients With Amyloid Cardiomyopathy Listed for Heart Transplantation
Akintoye E, Salih M, Aje K, Alvarez P, Sellke F, Briasoulis A, Dorbala S. Trends and Outcomes of Patients With Amyloid Cardiomyopathy Listed for Heart Transplantation. Canadian Journal Of Cardiology 2022, 38: 1263-1270. PMID: 35525397, DOI: 10.1016/j.cjca.2022.04.023.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmyloidosisCardiomyopathy, DilatedHeart TransplantationHumansRetrospective StudiesWaiting ListsConceptsHeart transplantGraft survivalAmyloid cardiomyopathyWaitlist mortalityHeart transplantationRisk factorsSingle-organ heart transplantsStudy periodHeart transplant waitlistUnderwent heart transplantWorse graft survivalGraft survival ratesOutcomes of patientsPropensity-matched cohortOrgan Sharing databaseHigher waitlist mortalityNumber of patientsNumber of transplantsAmyloid recurrenceAdult patientsGraft failureRenal failureIndependent predictorsSharing databaseUnited NetworkImpact of chronic kidney disease on in-hospital mortality and clinical outcomes of catheter ablation of ventricular tachycardia: Insights from the national readmission database
Khalil M, Maraey A, Aglan A, Akintoye E, Salem M, Elzanaty A, Younes A, Saeyeldin A, Barbhaiya C, Shokr M. Impact of chronic kidney disease on in-hospital mortality and clinical outcomes of catheter ablation of ventricular tachycardia: Insights from the national readmission database. Journal Of Interventional Cardiac Electrophysiology 2022, 66: 323-331. PMID: 35314904, DOI: 10.1007/s10840-022-01187-z.Peer-Reviewed Original ResearchMeSH KeywordsAgedArrhythmias, CardiacCatheter AblationHospital MortalityHumansPatient ReadmissionRetrospective StudiesTachycardia, VentricularTreatment OutcomeConceptsChronic kidney diseaseNational Readmission DatabaseClinical outcomesVentricular tachycardiaCatheter ablationKidney diseaseHospital mortalityVT ablationOdds ratioCorresponding diagnosis codesUnderwent catheter ablationAcute kidney injuryTotal hospital chargesWorse clinical outcomesMean lengthMultivariable regression analysisCKD groupConclusionIn patientsGroup patientsKidney injurySecondary outcomesHospital chargesDiagnosis codesClinical dataEffective treatmentOutcomes of diabetic patients with end‐stage heart failure listed for heart transplantation: A propensity‐matched analysis
Akintoye E, Alvarez P, Salih M, Sellke F, Briasoulis A. Outcomes of diabetic patients with end‐stage heart failure listed for heart transplantation: A propensity‐matched analysis. Clinical Transplantation 2022, 36: e14590. PMID: 35018661, DOI: 10.1111/ctr.14590.Peer-Reviewed Original ResearchMeSH KeywordsAdultDiabetes MellitusGraft SurvivalHeart FailureHeart TransplantationHumansRetrospective StudiesWaiting ListsConceptsDiabetic patientsWaitlist mortalityHeart transplantPost-transplant graft survivalEnd-stage heart failurePropensity-matched cohortHeart failure patientsGraft survivalAdult patientsFailure patientsGraft failureHeart failureUnited NetworkRisk factorsOrgan SharingPatientsStudy periodTransplantMortalityFailureCohortWaitlist
2021
Prognostic Implications of Ambulatory N-Terminal Pro-B-Type Natriuretic Peptide Changes in Patients with Continuous-Flow Left Ventricular Assist Devices
Ali A, Akintoye E, Duque E, Kshetri R, Shetty S, Sharma U, Johnson C, Panos A, Briasoulis A, Alvarez P. Prognostic Implications of Ambulatory N-Terminal Pro-B-Type Natriuretic Peptide Changes in Patients with Continuous-Flow Left Ventricular Assist Devices. ASAIO Journal 2021, 68: 524-530. PMID: 34352812, DOI: 10.1097/mat.0000000000001524.Peer-Reviewed Original ResearchConceptsNT-pro BNP concentrationHF hospitalizationBNP concentrationsVentricular assist devicePrognostic implicationsN-terminal pro-B-type natriuretic peptidePro-B-type natriuretic peptideAssist deviceHeart failure hospitalizationNT-pro BNPFailure hospitalizationIndex hospitalizationAdverse eventsLVAD implantationConsecutive patientsAmbulatory patientsNatriuretic peptideRetrospective studyHospitalizationAmbulatory settingPatientsMonth baselineMonthsDeathUnit increase
2020
Effect of Concurrent Dementia on Heart Failure Hospital Outcomes: Nationwide Inpatient Sample (2007–2014)
Vuong J, Akintoye E, Kim S, Desai A, Dorbala S. Effect of Concurrent Dementia on Heart Failure Hospital Outcomes: Nationwide Inpatient Sample (2007–2014). Journal Of Cardiac Failure 2020, 27: 258-260. PMID: 32505818, DOI: 10.1016/j.cardfail.2020.05.020.Peer-Reviewed Original ResearchIncidence and clinical outcomes of bleeding complications and acute limb ischemia in STEMI and cardiogenic shock
Pahuja M, Ranka S, Chehab O, Mishra T, Akintoye E, Adegbala O, Yassin A, Ando T, Thayer K, Shah P, Kimmelstiel C, Salehi P, Kapur N. Incidence and clinical outcomes of bleeding complications and acute limb ischemia in STEMI and cardiogenic shock. Catheterization And Cardiovascular Interventions 2020, 97: 1129-1138. PMID: 32473083, PMCID: PMC8344361, DOI: 10.1002/ccd.29003.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionAcute limb ischemiaLength of stayCardiogenic shockCS-STEMIHospital mortalityVascular complicationsLimb ischemiaClinical outcomesManagement of CSPercutaneous ventricular assist deviceIntra-aortic balloon pumpPercutaneous mechanical circulatory supportRetrospective cohort studyElevation myocardial infarctionMechanical circulatory supportVentricular assist deviceU.S. national databaseTandem HeartMultiorgan failureCohort studyBalloon pumpCommon complicationMembrane oxygenationCirculatory supportTrends, Outcomes, and Readmissions Among Left Ventricular Assist Device Recipients with Acute Kidney Injury Requiring Hemodialysis.
Adegbala O, Olakanmi O, Akintoye E, Inampudi C, Pahuja M, Alvarez P, Briasoulis A. Trends, Outcomes, and Readmissions Among Left Ventricular Assist Device Recipients with Acute Kidney Injury Requiring Hemodialysis. ASAIO Journal 2020, 66: 507-512. PMID: 31192850, DOI: 10.1097/mat.0000000000001036.Peer-Reviewed Original ResearchConceptsAcute kidney injuryLength of stayHospital mortalityKidney injuryLVAD recipientsMaintenance hemodialysisLVAD implantationAcute Kidney Injury Requiring HemodialysisVentricular assist device implantationVentricular assist device recipientsNational Readmission DatabaseAssist device implantationReduced hospital costsHospital outcomesPostoperative bleedingHospital dischargeRenal functionDevice implantationDevice recipientsHemodialysis therapyHospital characteristicsHospital costsHemodialysisReadmissionPatientsTemporal trends and outcomes of patients waiting on left ventricular assist devices and inotropes for heart transplantation
Briasoulis A, Adegbala O, Akintoye E, Alvarez P. Temporal trends and outcomes of patients waiting on left ventricular assist devices and inotropes for heart transplantation. Clinical Transplantation 2020, 34: e13857. PMID: 32167606, DOI: 10.1111/ctr.13857.Peer-Reviewed Original ResearchMeSH KeywordsAdultHeart FailureHeart TransplantationHeart-Assist DevicesHumansRegistriesRetrospective StudiesTreatment OutcomeWaiting ListsConceptsLeft ventricular assist deviceRight ventricular assist deviceVentricular assist deviceOutcomes of patientsTime of listingTime of transplantationHeart transplantationAssist deviceOrgan Sharing registryTerms of survivalStatus 1AInotropic therapyLVAD recipientsUnited NetworkWorse outcomesInotropesHigh riskWaiting listPatientsTransplantationLower ratesOutcomesTemporal trendsConfoundersRegistryPalliative Care in Ruptured Aortic Aneurysm in the United States: A Retrospective Analysis of Nationwide Inpatient Sample Database
Ando T, Adegbala O, Uemura T, Ashraf S, Akintoye E, Pahuja M, Afonso L, Briasoulis A, Takagi H. Palliative Care in Ruptured Aortic Aneurysm in the United States: A Retrospective Analysis of Nationwide Inpatient Sample Database. Angiology 2020, 71: 633-640. PMID: 32249588, DOI: 10.1177/0003319720917239.Peer-Reviewed Original ResearchConceptsLength of stayHospitalization costsPalliative careAortic aneurysmRepair groupNationwide Inpatient Sample databasePalliative care referralPC referral ratePercutaneous repair groupRuptured Aortic AneurysmSurgical repair groupNationwide Inpatient SamplePC referralCare referralInpatient SampleReferral ratesRetrospective analysisAdmissionStudy periodSample databaseFurther studiesStayAneurysmsReferralCare
2019
Gender Differences in Outcomes After Implantation of Left Ventricular Assist Devices
Ahmed A, Adegbala O, Akintoye E, Inampudi C, Ajam M, Yassin A, Olawusi E, Shokr M, Alvarez P, Briasoulis A. Gender Differences in Outcomes After Implantation of Left Ventricular Assist Devices. The Annals Of Thoracic Surgery 2019, 109: 780-786. PMID: 31479642, DOI: 10.1016/j.athoracsur.2019.07.032.Peer-Reviewed Original ResearchConceptsLVAD implantationContinuous-flow LVADVentricular assist device implantationLeft ventricular assist deviceAcute kidney injuryAssist device implantationMost common complicationsExtracorporeal membrane oxygenationMedian hospitalization costNational Inpatient SamplePostoperative cardiac tamponadeLength of stayYears of ageVentricular assist deviceGender-specific differencesHospital mortalityPostoperative thromboembolismCardiac tamponadeHospital outcomesKidney injuryPeriprocedural complicationsPostoperative sepsisCommon complicationInpatient mortalityLVAD placementA Doppler Echocardiographic Pulmonary Flow Marker of Massive or Submassive Acute Pulmonary Embolus
Afonso L, Sood A, Akintoye E, Gorcsan J, Rehman M, Kumar K, Javed A, Kottam A, Cardozo S, Singh M, Palla M, Ando T, Adegbala O, Shokr M, Briasoulis A. A Doppler Echocardiographic Pulmonary Flow Marker of Massive or Submassive Acute Pulmonary Embolus. Journal Of The American Society Of Echocardiography 2019, 32: 799-806. PMID: 31056367, DOI: 10.1016/j.echo.2019.03.004.Peer-Reviewed Original ResearchConceptsMassive pulmonary embolismSubmassive pulmonary embolismPulmonary embolismSubsegmental pulmonary embolismMcConnell's signExtent of PEDoppler flow patternsAcute pulmonary emboliFuture prospective studiesCharacteristic curve analysisSpectral Doppler interrogationAlternative imaging modalityNoninvasive signsUnderwent echocardiographyEchocardiographic parametersPulmonary hypertensionPulmonary emboliEchocardiography parametersProspective studyDoppler interrogationTomographic angiographyDeceleration timeDoppler variablesClinical utilityPatientsTrends in the Incidence of In-Hospital Mortality, Cardiogenic Shock, and Utilization of Mechanical Circulatory Support Devices in Myocarditis (Analysis of National Inpatient Sample Data, 2005–2014)
Pahuja M, Adegbala O, Mishra T, Akintoye E, Chehab O, Mony S, Singh M, Ando T, Abubaker H, Yassin A, Subahi A, Shokr M, Ranka S, Briasoulis A, Kapur N, Burkhoff D, Afonso L. Trends in the Incidence of In-Hospital Mortality, Cardiogenic Shock, and Utilization of Mechanical Circulatory Support Devices in Myocarditis (Analysis of National Inpatient Sample Data, 2005–2014). Journal Of Cardiac Failure 2019, 25: 457-467. PMID: 31035007, DOI: 10.1016/j.cardfail.2019.04.012.Peer-Reviewed Original ResearchConceptsIncidence of CSCardiogenic shockMechanical circulatory supportHospital mortalityMCS devicesPercutaneous ventricular assist deviceNational Inpatient Sample databaseMechanical circulatory support devicesIncidence of myocarditisPercutaneous cardiopulmonary supportCases of myocarditisIn-Hospital MortalityExtracorporeal membrane oxygenationCirculatory support devicesVentricular assist deviceTandem HeartHemodynamic instabilityMultiple comorbiditiesCardiopulmonary supportEndomyocardial biopsyMembrane oxygenationTotal admissionsCirculatory supportPatient mortalityPoor prognosisCardiac Implantable Electronic Devices in Adults with Tetralogy of Fallot
Egbe A, Vallabhajosyula S, Akintoye E, Deshmukh A. Cardiac Implantable Electronic Devices in Adults with Tetralogy of Fallot. The American Journal Of Cardiology 2019, 123: 1999-2001. PMID: 30961908, DOI: 10.1016/j.amjcard.2019.03.010.Peer-Reviewed Original ResearchConceptsCardiac implantable electronic devicesImplantable electronic devicesNationwide/National Inpatient SampleInflation-adjusted hospitalization costsNational Inpatient Sample databaseCharlson Comorbidity IndexMean hospital lengthPopulation-based studyNational Inpatient SampleSudden cardiac deathTetralogy of FallotTime of implantationComorbidity indexHospital lengthHospital mortalityCardiac deathTOF repairRepaired tetralogyRetrospective reviewHospitalization costsCIED implantationInpatient SampleTOF populationAdmissionObserved temporal increaseOptimum age for performing Fontan operation in patients with univentricular heart
Akintoye E, Veldtman G, Miranda W, Connolly H, Egbe A. Optimum age for performing Fontan operation in patients with univentricular heart. Congenital Heart Disease 2019, 14: 138-139. PMID: 30945806, DOI: 10.1111/chd.12690.Peer-Reviewed Original ResearchTrends in utilization, mortality, major complications, and cost after total artificial heart implantation in the United States (2009-2015)
Briasoulis A, Akintoye E, Mohsen A, Inampudi C, Briasouli A, Asleh R, Alvarez P. Trends in utilization, mortality, major complications, and cost after total artificial heart implantation in the United States (2009-2015). Hellenic Journal Of Cardiology 2019, 61: 407-412. PMID: 30790715, DOI: 10.1016/j.hjc.2019.02.002.Peer-Reviewed Original ResearchMeSH KeywordsAdultHeart FailureHeart TransplantationHeart, ArtificialHeart-Assist DevicesHospital MortalityHumansRetrospective StudiesUnited StatesConceptsLength of stayTotal artificial heartHospital mortalityHeart transplantationTAH implantationMajor complicationsLeft ventricular assist device implantationVentricular assist device implantationTotal artificial heart implantationComplex congenital heart diseaseStudy periodAcute kidney injuryAssist device implantationSame hospital staySevere biventricular failureDisposition of patientsNational Inpatient SampleTime of dischargeContinuous-flow LVADCost of hospitalizationArtificial heart implantationCongenital heart diseaseHospital complicationsMajor bleedingBiventricular failureTrends and Outcomes of Infective Endocarditis in Adults With Tetralogy of Fallot: A Review of the National Inpatient Sample Database
Egbe A, Vallabhajosyula S, Akintoye E, Connolly H. Trends and Outcomes of Infective Endocarditis in Adults With Tetralogy of Fallot: A Review of the National Inpatient Sample Database. Canadian Journal Of Cardiology 2019, 35: 721-726. PMID: 31151707, DOI: 10.1016/j.cjca.2019.02.006.Peer-Reviewed Original ResearchConceptsHealth care resource utilizationTetralogy of FallotProsthetic valve implantationNational Inpatient SampleCongenital heart diseaseHospital mortalityValve implantationInfective endocarditisHeart diseaseRisk factorsTOF patientsInflation-adjusted hospitalization costsNational Inpatient Sample databaseCyanotic congenital heart diseaseIncidence of endocarditisLength of stayPacemaker/defibrillatorLow socioeconomic classPopulation-based riskHospital dischargeSecondary outcomesPrimary outcomeHospitalization costsBlack raceInpatient SampleImpact of atrial fibrillation on patients hospitalized for acute myocarditis: Insights from a nationally‐representative United States cohort
Subahi A, Akintoye E, Yassin A, Abubakar H, Adegbala O, Mishra T, Abdelrahman M, Shokr M, Afonso L. Impact of atrial fibrillation on patients hospitalized for acute myocarditis: Insights from a nationally‐representative United States cohort. Clinical Cardiology 2019, 42: 26-31. PMID: 30284301, PMCID: PMC6436524, DOI: 10.1002/clc.23088.Peer-Reviewed Original ResearchConceptsAtrial fibrillationHospital mortalityHospital outcomesAcute myocarditisICD-9-CM diagnostic codesNon-routine hospital dischargeImpact of AFPropensity score-matched control groupAcute myocarditis patientsAcute kidney injuryUnited States cohortNational Inpatient SampleCardiac tamponadeCardiogenic shockCause mortalityKidney injuryMyocarditis patientsAM patientsHospital dischargeAF groupInpatient SamplePrimary diagnosisDiagnostic codesHigh riskGeneral population