2022
Trends and Outcomes of Patients With Amyloid Cardiomyopathy Listed for Heart Transplantation
Akintoye E, Salih M, Aje K, Alvarez P, Sellke F, Briasoulis A, Dorbala S. Trends and Outcomes of Patients With Amyloid Cardiomyopathy Listed for Heart Transplantation. Canadian Journal Of Cardiology 2022, 38: 1263-1270. PMID: 35525397, DOI: 10.1016/j.cjca.2022.04.023.Peer-Reviewed Original ResearchConceptsHeart transplantGraft survivalAmyloid cardiomyopathyWaitlist mortalityHeart transplantationRisk factorsSingle-organ heart transplantsStudy periodHeart transplant waitlistUnderwent heart transplantWorse graft survivalGraft survival ratesOutcomes of patientsPropensity-matched cohortOrgan Sharing databaseHigher waitlist mortalityNumber of patientsNumber of transplantsAmyloid recurrenceAdult patientsGraft failureRenal failureIndependent predictorsSharing databaseUnited NetworkClinical, functional and prognostic implications of severe atrial dilation in secondary mitral regurgitation
Layoun H, Mentias A, Akintoye E, Matta M, Kanaan C, Daou R, Ramchand J, Burns D, Gillinov A, Bhattacharya S, Puri R, Collier P, Griffin B, Kapadia S, Harb S. Clinical, functional and prognostic implications of severe atrial dilation in secondary mitral regurgitation. Open Heart 2022, 9: e001996. PMID: 35383126, PMCID: PMC8984044, DOI: 10.1136/openhrt-2022-001996.Peer-Reviewed Original ResearchConceptsSecondary mitral regurgitationAtrial dilationMitral regurgitationPrognostic implicationsSevere left atrial dilationSevere secondary mitral regurgitationLA reservoir strainLeft atrial dilationLeft ventricle dysfunctionPoor prognostic indicatorMV interventionVentricle dysfunctionMore diabetesAdult patientsTransthoracic echocardiographyEjection fractionIndependent predictorsAtrial fibrillationReservoir strainWorse prognosisPrognostic indicatorMR severityBetter outcomesFunctional alterationsPatients
2019
Left Ventricular Systolic Dysfunction and Cardiovascular Outcomes in Tetralogy of Fallot: Systematic Review and Meta-analysis
Egbe A, Adigun R, Anand V, West C, Montori V, Murad M, Akintoye E, Osman K, Connolly H. Left Ventricular Systolic Dysfunction and Cardiovascular Outcomes in Tetralogy of Fallot: Systematic Review and Meta-analysis. Canadian Journal Of Cardiology 2019, 35: 1784-1790. PMID: 31732195, DOI: 10.1016/j.cjca.2019.07.634.Peer-Reviewed Original ResearchConceptsCardiovascular adverse eventsLV ejection fractionLeft ventricular systolic dysfunctionLV systolic dysfunctionVentricular systolic dysfunctionSystolic dysfunctionHazard ratioLV systolic functionSudden cardiac deathNew treatment optionsClinical risk stratificationConfidence intervalsTetralogy of FallotVentricular tachycardia eventsRandom-effects modelCardiovascular outcomesAdverse eventsSystolic functionCardiac deathEjection fractionIndependent predictorsRisk stratificationPrognostic implicationsTreatment optionsTachycardia events
2018
Predictors, Burden, and the Impact of Arrhythmia on Patients Admitted for Acute Myocarditis
Adegbala O, Olagoke O, Akintoye E, Adejumo A, Oluwole A, Jara C, Williams K, Briasoulis A, Afonso L. Predictors, Burden, and the Impact of Arrhythmia on Patients Admitted for Acute Myocarditis. The American Journal Of Cardiology 2018, 123: 139-144. PMID: 30539745, DOI: 10.1016/j.amjcard.2018.09.017.Peer-Reviewed Original ResearchConceptsImpact of arrhythmiasCardiac arrhythmiasAcute myocarditisNonroutine hospital dischargePredictors of arrhythmiasPropensity-matched analysisMechanical circulatory supportSudden cardiac deathOccurrence of arrhythmiasCost of hospitalizationLength of staySignificant proportionHospital mortalityCardiogenic shockHospital outcomesHospital dischargeMyocarditis casesCardiac deathIndependent predictorsPacemaker implantationAtrial fibrillationCirculatory supportCommon arrhythmiaVentricular tachycardiaWorse outcomesIncidence and outcomes of cardiac tamponade in patients undergoing cardiac resynchronization therapy
Adegbala O, Olagoke O, Adejumo A, Akintoye E, Oluwole A, Alebna P, Williams K, Lieberman R, Afonso L. Incidence and outcomes of cardiac tamponade in patients undergoing cardiac resynchronization therapy. International Journal Of Cardiology 2018, 272: 137-141. PMID: 30045818, DOI: 10.1016/j.ijcard.2018.07.084.Peer-Reviewed Original ResearchConceptsNationwide Inpatient SampleCRT implantationCardiac tamponadeCoagulation disordersCardiac resynchronization therapy implantationHierarchical mixed-effects logistic regression modelsDevelopment of tamponadePropensity-matched analysisCardiac resynchronization therapyMixed effects logistic regression modelsLogistic regression modelsHospital mortalityHospital stayMultivariable adjustmentCABG proceduresHospitalized patientsIndependent predictorsResynchronization therapySevere complicationsRisk stratificationFemale sexInpatient SampleFemale genderHigher oddsPrior history
2017
Biochemical risk markers and 10-year incidence of atherosclerotic cardiovascular disease: independent predictors, improvement in pooled cohort equation, and risk reclassification
Akintoye E, Briasoulis A, Afonso L. Biochemical risk markers and 10-year incidence of atherosclerotic cardiovascular disease: independent predictors, improvement in pooled cohort equation, and risk reclassification. American Heart Journal 2017, 193: 95-103. PMID: 29129262, DOI: 10.1016/j.ahj.2017.08.002.Peer-Reviewed Original ResearchConceptsPooled Cohort EquationsNet reclassification indexBiochemical risk markersBiomarker scoreCohort EquationsC-statisticRisk markersTreatment decisionsPrimary atherosclerotic cardiovascular disease (ASCVD) preventionAtherosclerotic cardiovascular disease preventionCategorical net reclassification indexSensitivity C-reactive proteinCategory-free net reclassification indexN-terminal prohormoneBrain natriuretic peptideAtherosclerotic cardiovascular diseaseCardiovascular disease preventionC-reactive proteinMulti-Ethnic StudyRate of incidentsASCVD preventionIndependent predictorsNet reclassificationNatriuretic peptideRisk reclassification