2019
Clinical Impact of Atrial Fibrillation on Short-Term Outcomes and In-Hospital Mortality in Patients with Takotsubo Syndrome: A Propensity-Matched National Study
Yassin A, Subahi A, Adegbala O, Abubakar H, Dawdy J, Mishra T, Akintoye E, Shereef H, Ghandour M, Alhusain R, Shokr M, Oviedo C, Afonso L. Clinical Impact of Atrial Fibrillation on Short-Term Outcomes and In-Hospital Mortality in Patients with Takotsubo Syndrome: A Propensity-Matched National Study. Cardiovascular Revascularization Medicine 2019, 21: 522-526. PMID: 31439442, DOI: 10.1016/j.carrev.2019.07.022.Peer-Reviewed Original ResearchConceptsCost of hospitalizationAtrial fibrillationHospital mortalityHospital complicationsVentricular arrhythmiasNational Inpatient Sample databasePropensity score-matched analysisMajor cardiac complicationsTakotsubo syndrome patientsIn-Hospital MortalityNon-routine dischargeAtrial fibrillation groupAtrial fibrillation patientsShort-term outcomesNational Inpatient SampleLength of stayPotential confounding factorsCardiac complicationsHospital stayFibrillation groupFibrillation patientsSecondary outcomesTakotsubo syndromePrimary outcomeCardiac arrestTrends in In-Hospital Mortality, Length of Stay, Nonroutine Discharge, and Cost Among End-Stage Renal Disease Patients on Dialysis Hospitalized With Heart Failure (2001–2014)
Inampudi C, Akintoye E, Bengaluru Jayanna M, Asleh R, Briasouli A, Alvarez P, Briasoulis A. Trends in In-Hospital Mortality, Length of Stay, Nonroutine Discharge, and Cost Among End-Stage Renal Disease Patients on Dialysis Hospitalized With Heart Failure (2001–2014). Journal Of Cardiac Failure 2019, 25: 524-533. PMID: 30844441, DOI: 10.1016/j.cardfail.2019.02.020.Peer-Reviewed Original ResearchConceptsLength of stayEnd-stage renal disease patientsHF admissionsRenal disease patientsHospital mortalityNonroutine dischargeHeart failureESRD patientsDisease patientsStudy periodAnnual national ratesHF admission ratesPrevalence of comorbiditiesIn-Hospital MortalityNational Inpatient SampleCost of hospitalizationAnnual percentage changeYears of ageHF hospitalizationSecondary admissionsAdmission diagnosisComorbidity prevalencePeritoneal dialysisSubgroup analysisInpatient SampleTrends in utilization, mortality, major complications, and cost after total artificial heart implantation in the United States (2009-2015)
Briasoulis A, Akintoye E, Mohsen A, Inampudi C, Briasouli A, Asleh R, Alvarez P. Trends in utilization, mortality, major complications, and cost after total artificial heart implantation in the United States (2009-2015). Hellenic Journal Of Cardiology 2019, 61: 407-412. PMID: 30790715, DOI: 10.1016/j.hjc.2019.02.002.Peer-Reviewed Original ResearchConceptsLength of stayTotal artificial heartHospital mortalityHeart transplantationTAH implantationMajor complicationsLeft ventricular assist device implantationVentricular assist device implantationTotal artificial heart implantationComplex congenital heart diseaseStudy periodAcute kidney injuryAssist device implantationSame hospital staySevere biventricular failureDisposition of patientsNational Inpatient SampleTime of dischargeContinuous-flow LVADCost of hospitalizationArtificial heart implantationCongenital heart diseaseHospital complicationsMajor bleedingBiventricular failurePredictors of Hospital Cost After Transcatheter Aortic Valve Implantation in the United States: From the Nationwide Inpatient Sample Database
Ando T, Adegbala O, Villablanca P, Akintoye E, Ashraf S, Briasoulis A, Telila T, Takagi H, Grines C, Schreiber T, Bhatt D, Afonso L. Predictors of Hospital Cost After Transcatheter Aortic Valve Implantation in the United States: From the Nationwide Inpatient Sample Database. The American Journal Of Cardiology 2019, 123: 1142-1148. PMID: 30658917, DOI: 10.1016/j.amjcard.2018.12.044.Peer-Reviewed Original ResearchMeSH KeywordsAged, 80 and overAortic Valve StenosisDatabases, FactualFemaleHospital CostsHospital MortalityHospitalizationHumansIncidenceInpatientsMalePatient Acceptance of Health CarePostoperative ComplicationsPropensity ScoreRisk FactorsTime FactorsTranscatheter Aortic Valve ReplacementUnited StatesConceptsTranscatheter aortic valve implantationNationwide Inpatient Sample databaseHigh-cost groupHigher hospitalization costsAortic valve implantationHospitalization costsValve implantationHospital costsSample databaseSurgical aortic valve replacementCost groupsHigher co-morbidity burdenAcute kidney injuryAcute respiratory failureAortic valve replacementPeripheral vascular diseaseCo-morbidity burdenCost of hospitalizationLength of stayMultivariable regression analysisLow-cost groupHigh incremental costPost-TAVITAVI hospitalizationsCardiogenic shock
2018
Clinical Impact of Diabetes Mellitus on Short-Term Outcomes andIn-Hospital Mortality of Cardiac Mechanical Support with Left Ventricular Assist Device (LVAD): A Retrospective Study from a National Database
Yassin A, Subahi A, Adegbala O, Abubakar H, Akintoye E, Ahmed A, Ismail A, Elhag A, Kambal A, Alade A, Shokr M, Weinberger J, Levine D, Afonso L. Clinical Impact of Diabetes Mellitus on Short-Term Outcomes andIn-Hospital Mortality of Cardiac Mechanical Support with Left Ventricular Assist Device (LVAD): A Retrospective Study from a National Database. Cardiovascular Revascularization Medicine 2018, 20: 883-886. PMID: 30578171, DOI: 10.1016/j.carrev.2018.12.011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedDatabases, FactualDiabetes MellitusFemaleHeart FailureHeart-Assist DevicesHospital MortalityHumansMaleMiddle AgedProsthesis DesignProsthesis ImplantationRecovery of FunctionRegistriesRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesVentricular Dysfunction, LeftVentricular Function, LeftConceptsLeft ventricular assist deviceCardiac mechanical supportDiabetes mellitusCost of hospitalizationCardiac supportVentricular assist deviceHospital mortalityDiabetic patientsHeart failureClinical impactMultivariable logistic regression model analysisAssist deviceStage D heart failureAdvanced congestive heart failureNational Inpatient Sample databasePost-LVAD complicationsShort-term complicationsCongestive heart failureLogistic regression model analysisHospital-level characteristicsImpact of diabetesRegression model analysisInpatient mortalityLVAD implantationSecondary outcomesComparison of In-Hospital Outcomes of Patients With-Versus-Without Ischemic Cardiomyopathy Undergoing Left Ventricular Assist Device Placement
Abubakar H, Subahi A, Adegbala O, Yassin A, Akintoye E, Abdulrahman A, Ahmed A, Alade A, Pahuja M, Afonso L. Comparison of In-Hospital Outcomes of Patients With-Versus-Without Ischemic Cardiomyopathy Undergoing Left Ventricular Assist Device Placement. The American Journal Of Cardiology 2018, 123: 414-418. PMID: 30545482, DOI: 10.1016/j.amjcard.2018.10.039.Peer-Reviewed Original ResearchConceptsVentricular assist device placementPostoperative myocardial infarctionLength of stayHospital mortalityVascular complicationsLVAD placementMyocardial infarctionEnd pointLeft ventricular assist device placementNationwide Inpatient Sample databaseST-segment myocardial infarctionDevice placementPeriprocedural vascular complicationsHeart failure etiologyIn-Hospital OutcomesPrimary end pointSecondary end pointsClinical end pointsHospital-level characteristicsCost of hospitalizationHemorrhage requiring transfusionMixed-effects logistic modelHospital outcomesFailure etiologyIschemic cardiomyopathyThe impact of atrial fibrillation on transcatheter mitral valve repair outcomes: A propensity‐matched analysis
Subahi A, Munir A, Abubakar H, Akintoye E, Yassin A, Adegbala O, Alraies M, Elder M, Mohamad T, Kaki A, Schreiber T. The impact of atrial fibrillation on transcatheter mitral valve repair outcomes: A propensity‐matched analysis. Journal Of Interventional Cardiology 2018, 31: 925-931. PMID: 30456770, DOI: 10.1111/joic.12568.Peer-Reviewed Original ResearchConceptsTranscatheter mitral valve repairAtrial fibrillationHospital outcomesTranscatheter Mitral Valve Repair OutcomesICD-9-CM diagnostic codesMitral valve repair outcomesNational Inpatient Sample registryNon-routine hospital dischargeImpact of AFPrevalence of AFPropensity score-matched analysisHigher AF burdenPropensity-matched analysisRepresentative United States sampleHospital-level characteristicsMitral valve repairCost of hospitalizationLength of stayHospital mortalityAF burdenHospital dischargePatient characteristicsAF patientsBaseline rhythmTMVR proceduresEffect of Hospital Ownership on Outcomes After Left Ventricular Assist Device Implantation in the United States
Briasoulis A, Inampudi C, Akintoye E, Adegbala O, Bhama J, Alvarez P. Effect of Hospital Ownership on Outcomes After Left Ventricular Assist Device Implantation in the United States. The Annals Of Thoracic Surgery 2018, 107: 527-532. PMID: 30316859, DOI: 10.1016/j.athoracsur.2018.08.051.Peer-Reviewed Original ResearchPredictors, Burden, and the Impact of Arrhythmia on Patients Admitted for Acute Myocarditis
Adegbala O, Olagoke O, Akintoye E, Adejumo A, Oluwole A, Jara C, Williams K, Briasoulis A, Afonso L. Predictors, Burden, and the Impact of Arrhythmia on Patients Admitted for Acute Myocarditis. The American Journal Of Cardiology 2018, 123: 139-144. PMID: 30539745, DOI: 10.1016/j.amjcard.2018.09.017.Peer-Reviewed Original ResearchConceptsImpact of arrhythmiasCardiac arrhythmiasAcute myocarditisNonroutine hospital dischargePredictors of arrhythmiasPropensity-matched analysisMechanical circulatory supportSudden cardiac deathOccurrence of arrhythmiasCost of hospitalizationLength of staySignificant proportionHospital mortalityCardiogenic shockHospital outcomesHospital dischargeMyocarditis casesCardiac deathIndependent predictorsPacemaker implantationAtrial fibrillationCirculatory supportCommon arrhythmiaVentricular tachycardiaWorse outcomesClinical impact of advanced chronic kidney disease on outcomes and in-hospital complications of Takotsubo Syndrome (broken-heart-syndrome): Propensity-matched national study
Yassin A, Adegbala O, Subahi A, Abubakar H, Akintoye E, Abdelrahamn M, Ahmed A, Agarwal A, Shokr M, Pahuja M, Elder M, Kaki A, Schreiber T, Mohamad T. Clinical impact of advanced chronic kidney disease on outcomes and in-hospital complications of Takotsubo Syndrome (broken-heart-syndrome): Propensity-matched national study. International Journal Of Cardiology 2018, 277: 16-19. PMID: 30293663, DOI: 10.1016/j.ijcard.2018.09.098.Peer-Reviewed Original ResearchConceptsAdvanced chronic kidney diseaseChronic kidney diseaseAcute kidney injuryTakotsubo syndromeHospital complicationsKidney diseaseCKD groupImpact of CKDNational Inpatient Sample databasePropensity score-matched analysisAdvanced CKD groupAdvanced CKD patientsIn-Hospital MortalityCost of hospitalizationCKD patientsHospital mortalityHospital lengthHospital stayKidney injuryComplication rateInpatient mortalitySecondary outcomesTakotsubo cardiomyopathyPrimary outcomeClinical outcomesComparison of Hospital Outcomes of Transcatheter AorticValve Implantation With Versus Without Hypothyroidism
Subahi A, Yassin A, Adegbala O, Akintoye E, Abubakar H, Elmoghrabi A, Ibrahim W, Ajam M, Pahuja M, Weinberger J, Levine D, Afonso L. Comparison of Hospital Outcomes of Transcatheter AorticValve Implantation With Versus Without Hypothyroidism. The American Journal Of Cardiology 2018, 122: 838-843. PMID: 30037424, DOI: 10.1016/j.amjcard.2018.05.025.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationHypothyroid patientsImpact of hypothyroidismHospital outcomesSevere symptomatic aortic stenosisNational Inpatient Sample databasePropensity score-matched analysisSymptomatic aortic stenosisAdditional randomized trialsAortic valve implantationCost of hospitalizationHemorrhage requiring transfusionEffect of hypothyroidismHospital mortalityTAVR outcomesHospital stayInpatient mortalityPostprocedural complicationsSecondary outcomesValve implantationAortic stenosisBlood transfusionPrimary outcomeClinical outcomesRandomized trialsOutcomes and Effects of Hepatic Cirrhosis in Patients Who Underwent Transcatheter Aortic Valve Implantation
Yassin A, Subahi A, Abubakar H, Akintoye E, Alhusain R, Adegbala O, Ahmed A, Elmoughrabi A, Subahi E, Pahuja M, Sahlieh A, Elder M, Kaki A, Schreiber T, Mohamad T. Outcomes and Effects of Hepatic Cirrhosis in Patients Who Underwent Transcatheter Aortic Valve Implantation. The American Journal Of Cardiology 2018, 122: 455-460. PMID: 30041889, DOI: 10.1016/j.amjcard.2018.04.013.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationAortic valve implantationLiver cirrhosisCirrhotic patientsValve implantationUnderwent Transcatheter Aortic Valve ImplantationNational Inpatient Sample databasePropensity score-matched analysisNonroutine hospital dischargeSevere aortic stenosisAortic valve replacementReasonable therapeutic optionCost of hospitalizationHospital mortalityHospital stayVascular complicationsHospital dischargeInpatient mortalitySecondary outcomesValve replacementAortic stenosisPacemaker implantationPrimary outcomeProcedural complicationsClinical outcomesFinancial Implications and Impact of Pre-existing Atrial Fibrillation on In-Hospital Outcomes in Patients Who Underwent Transcatheter Aortic Valve Implantation (from the National Inpatient Database)
Abubakar H, Yassin A, Akintoye E, Bakhit K, Pahuja M, Shokr M, Lieberman R, Afonso L. Financial Implications and Impact of Pre-existing Atrial Fibrillation on In-Hospital Outcomes in Patients Who Underwent Transcatheter Aortic Valve Implantation (from the National Inpatient Database). The American Journal Of Cardiology 2018, 121: 1587-1592. PMID: 29622287, DOI: 10.1016/j.amjcard.2018.02.052.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic Valve StenosisArrhythmias, CardiacAtrial FibrillationCardiac Pacing, ArtificialCardiac TamponadeComorbidityDatabases, FactualFemaleHeart ArrestHeart FailureHospital CostsHospital MortalityHumansLength of StayLinear ModelsLogistic ModelsMaleMyocardial InfarctionPacemaker, ArtificialPericardial EffusionPostoperative ComplicationsPostoperative HemorrhageStrokeTranscatheter Aortic Valve ReplacementUnited StatesConceptsTranscatheter aortic valve implantationPre-existing atrial fibrillationLength of stayPeriprocedural cardiac complicationsAortic valve implantationAtrial fibrillationCost of hospitalizationCardiac complicationsHospital mortalityEnd pointValve implantationLonger hospital LOSUnderwent Transcatheter Aortic Valve ImplantationPre-existing AFHospital LOSIncidence of AFLonger LOSNationwide Inpatient Sample databaseIn-Hospital OutcomesPrimary end pointSecondary end pointsClinical end pointsHospital-level characteristicsMixed-effects logistic modelTAVI patientsTrends in Utilization, Mortality, Major Complications, and Cost After Left Ventricular Assist Device Implantation in the United States (2009 to 2014)
Briasoulis A, Inampudi C, Akintoye E, Adegbala O, Alvarez P, Bhama J. Trends in Utilization, Mortality, Major Complications, and Cost After Left Ventricular Assist Device Implantation in the United States (2009 to 2014). The American Journal Of Cardiology 2018, 121: 1214-1218. PMID: 29525059, DOI: 10.1016/j.amjcard.2018.01.041.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAdultAgedCardiac TamponadeDatabases, FactualFemaleHealth Care CostsHeart FailureHeart-Assist DevicesHospital CostsHospital MortalityHumansLength of StayLogistic ModelsMaleMiddle AgedMortalityMyocardial InfarctionPatient DischargePostoperative ComplicationsPostoperative HemorrhageProsthesis ImplantationRenal DialysisRespiratory Tract DiseasesStrokeSurgical Wound DehiscenceSurgical Wound InfectionUnited StatesConceptsLength of stayMajor complicationsHospital mortalityLeft ventricular assist device (LVAD) implantsVentricular assist device implantsVentricular assist device implantationAssist device implantationHospital mortality rateNational Inpatient SampleTime of dischargeCost of hospitalizationSignificant decreaseAnnual national estimatesVentricular assist deviceHospital complicationsMajor bleedingCardiac tamponadeRespiratory complicationsAdult patientsIschemic strokePostoperative infectionCF-LVADCF-LVADsDevice implantationInpatient Sample
2017
Effect of Hospital Ownership on Outcomes of Heart Failure Hospitalization
Akintoye E, Briasoulis A, Egbe A, Orhurhu V, Ibrahim W, Kumar K, Alliu S, Nas H, Levine D, Weinberger J. Effect of Hospital Ownership on Outcomes of Heart Failure Hospitalization. The American Journal Of Cardiology 2017, 120: 831-837. PMID: 28689752, DOI: 10.1016/j.amjcard.2017.06.009.Peer-Reviewed Original ResearchConceptsInpatient mortalityFemale patientsGovernment hospitalsHospitalization outcomesHospital ownershipSignificant differencesCharge of hospitalizationRoutine home dischargeHeart failure hospitalizationMean lengthNational Inpatient SampleCost of hospitalizationHF hospitalizationFailure hospitalizationHome dischargeHospital dischargeMale patientsInpatient SamplePrimary diagnosisProfit hospitalsHospitalizationMedian costMedian chargeMortality rateHospitalSEASONAL VARIATION IN IN-PATIENT MORTALITY, COST OF HOSPITALIZATION AND LENGTH OF STAY IN HEART FAILURE PATIENTS IN THE UNITED STATES
Akintoye E, Briasoulis A, Adegbala O, Sheikh M, Singh M, Ahmed A, Levine D. SEASONAL VARIATION IN IN-PATIENT MORTALITY, COST OF HOSPITALIZATION AND LENGTH OF STAY IN HEART FAILURE PATIENTS IN THE UNITED STATES. Journal Of The American College Of Cardiology 2017, 69: 759. DOI: 10.1016/s0735-1097(17)34148-7.Peer-Reviewed Original ResearchIMPACT OF HOSPITAL OWNERSHIP ON IN-PATIENT MORTALITY AND COST OF HOSPITALIZATION IN PATIENTS ADMITTED FOR HEART FAILURE: INSIGHT FROM THE NATIONAL INPATIENT SAMPLE (NIS)
Akintoye E, Briasoulis A, Orhurhu V, Ibrahim W, Kumar K, Nas H, Weinberger J. IMPACT OF HOSPITAL OWNERSHIP ON IN-PATIENT MORTALITY AND COST OF HOSPITALIZATION IN PATIENTS ADMITTED FOR HEART FAILURE: INSIGHT FROM THE NATIONAL INPATIENT SAMPLE (NIS). Journal Of The American College Of Cardiology 2017, 69: 770. DOI: 10.1016/s0735-1097(17)34159-1.Peer-Reviewed Original ResearchTranscatheter aortic valve implantation in the United States: Predictors of early hospital discharge
Mallikethi‐Reddy S, Akintoye E, Telila T, Sudhakar R, Jagadeesh K, Briasoulis A, Rubenfire M, Afonso L, Grines C. Transcatheter aortic valve implantation in the United States: Predictors of early hospital discharge. Journal Of Interventional Cardiology 2017, 30: 149-155. PMID: 28247569, DOI: 10.1111/joic.12373.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve implantationEarly hospital dischargeAortic valve implantationEarly dischargeDischarge cohortPost-TAVIAortic valvuloplastyHospital dischargeBlood transfusionValve implantationPermanent pacemakerNationwide Inpatient Sample databaseMechanical circulatory support devicesAcute kidney injuryEarly discharge cohortTransfemoral TAVI approachHigher hospitalization costsMechanical circulatory supportCost of hospitalizationOverall mean ageHealthcare Utilization ProjectCirculatory support devicesHospital outcomesKidney injuryRenal failure