2024
Total-Body PET/CT Applications in Cardiovascular Diseases: A Perspective Document of the SNMMI Cardiovascular Council
Slart R, Bengel F, Akincioglu C, Bourque J, Chen W, Dweck M, Hacker M, Malhotra S, Miller E, Pelletier-Galarneau M, Packard R, Schindler T, Weinberg R, Saraste A, Slomka P. Total-Body PET/CT Applications in Cardiovascular Diseases: A Perspective Document of the SNMMI Cardiovascular Council. Journal Of Nuclear Medicine 2024, 65: jnumed.123.266858. PMID: 38388512, DOI: 10.2967/jnumed.123.266858.Peer-Reviewed Original ResearchLong axial fieldAxial fieldCardiovascular diseaseLow-dose examinationsWhole-body coveragePET/CT systemField of cardiovascular diseaseCardiac physiologyAnatomic coveragePET/CT applicationsMultiple organsVascular structuresCardiovascular systemTracer kinetic modelAcquisition timeSimultaneous assessmentSystem sensitivityImage qualityDisease
2023
Autoimmune comorbidities associated with sarcoidosis: a case-control study in the All of Us research program
Murphy M, Edemobi P, Leasure A, Gulati M, Miller E, Damsky W, Cohen J. Autoimmune comorbidities associated with sarcoidosis: a case-control study in the All of Us research program. Rheumatology Advances In Practice 2023, 7: rkad030. PMID: 38606002, PMCID: PMC11007907, DOI: 10.1093/rap/rkad030.Peer-Reviewed Original ResearchCase-control studyAutoimmune diseasesSarcoidosis patientsMultivariable analysisOdds ratioSarcoidosis casesUs Research ProgramDiverse cohortConcomitant autoimmune diseasesRace-matched controlsMultiple autoimmune diseasesAutoimmune comorbiditiesSarcoidosisPatientsLogistic regressionDiseaseSmall sample sizeCareful screeningCohortAssociationSample sizeComposite variablePrior studiesComorbiditiesStudyMECHANISTIC EVALUATION OF AN AI-DRIVEN CLINICAL DECISION SUPPORT TOOL TO PERSONALIZE THE USE OF ANATOMICAL TESTING IN SUSPECTED CORONARY ARTERY DISEASE
Oikonomou E, Suchard M, Miller E, Velazquez E, Khera R. MECHANISTIC EVALUATION OF AN AI-DRIVEN CLINICAL DECISION SUPPORT TOOL TO PERSONALIZE THE USE OF ANATOMICAL TESTING IN SUSPECTED CORONARY ARTERY DISEASE. Journal Of The American College Of Cardiology 2023, 81: 1360. DOI: 10.1016/s0735-1097(23)01804-1.Peer-Reviewed Original ResearchNovel Radiotracers for Molecular Imaging of Myocardial Inflammation: an Update Focused on Clinical Translation of Non-18F-FDG Radiotracers
Shi T, Miller E. Novel Radiotracers for Molecular Imaging of Myocardial Inflammation: an Update Focused on Clinical Translation of Non-18F-FDG Radiotracers. Current Cardiovascular Imaging Reports 2023, 16: 1-9. PMID: 36926261, PMCID: PMC9996562, DOI: 10.1007/s12410-023-09574-4.Peer-Reviewed Original ResearchCardiac sarcoidosisMyocardial inflammatory diseaseDisease activityImmunomodulatory therapyInflammatory cardiomyopathyMyocardial inflammationInflammatory diseasesPrognostic performanceReviewThe purposeNovel radiotracersMyocarditisSarcoidosisTherapy guidanceInflammationMolecular featuresRadiotracerClinical translationMolecular imagingMolecular mechanismsHigh specificityCardiomyopathyImproved mechanistic insightsPathogenesisTherapyDisease
2022
Mitigating bias in deep learning for diagnosis of coronary artery disease from myocardial perfusion SPECT images
Miller RJH, Singh A, Otaki Y, Tamarappoo BK, Kavanagh P, Parekh T, Hu LH, Gransar H, Sharir T, Einstein AJ, Fish MB, Ruddy TD, Kaufmann PA, Sinusas AJ, Miller EJ, Bateman TM, Dorbala S, Di Carli MF, Liang JX, Dey D, Berman DS, Slomka PJ. Mitigating bias in deep learning for diagnosis of coronary artery disease from myocardial perfusion SPECT images. European Journal Of Nuclear Medicine And Molecular Imaging 2022, 50: 387-397. PMID: 36194270, PMCID: PMC10042590, DOI: 10.1007/s00259-022-05972-w.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseMyocardial perfusion imagingArtery diseaseInvasive angiographyObstructive coronary artery diseaseDisease probabilityLow-risk patientsLow-risk populationHigh-risk populationTotal perfusion deficitHigh diagnostic accuracyS-TPDPerfusion deficitsPatient managementPatientsPerfusion imagingDiagnostic accuracyPerfusion SPECT imagesLower likelihoodGood calibrationCharacteristic curveAngiographySPECT imagesSelection biasDisease
2021
Potential novel imaging targets of inflammation in cardiac sarcoidosis
Park J, Young BD, Miller EJ. Potential novel imaging targets of inflammation in cardiac sarcoidosis. Journal Of Nuclear Cardiology 2021, 29: 2171-2187. PMID: 34734365, DOI: 10.1007/s12350-021-02838-w.Peer-Reviewed Original ResearchConceptsCardiac sarcoidosisFDG-PET imagingPositron emission tomographyF-fluorodeoxyglucose positron emission tomographyNon-caseating granulomatous inflammationGranulomatous inflammationHigh morbiditySarcoid granulomasInflammatory diseasesPathognomonic featuresInflammationEmission tomographySarcoidosisMolecular targetsImaging targetsImagingMorbidityGranulomasMortalityDisease
2020
PROGNOSTIC IMPACT OF DIABETES IN PATIENTS WITH OR WITHOUT KNOWN CORONARY ARTERY DISEASE, RESULTS FROM THE REFINE SPECT REGISTRY
Han D, Otaki Y, Tzolos E, Klein E, Gransar H, Sharir T, Einstein A, Fish M, Ruddy T, Kaufmann P, Sinusas A, Miller E, Bateman T, Dorbala S, Di Carli M, Liang J, Dey D, Berman D, Slomka P. PROGNOSTIC IMPACT OF DIABETES IN PATIENTS WITH OR WITHOUT KNOWN CORONARY ARTERY DISEASE, RESULTS FROM THE REFINE SPECT REGISTRY. Journal Of The American College Of Cardiology 2020, 75: 1796. DOI: 10.1016/s0735-1097(20)32423-2.Peer-Reviewed Original ResearchIMPAIRED CORONARY FLOW RESERVE ON 82RUBIDIUM POSITRON EMISSION TOMOGRAPHY IMAGING PREDICTS ADVERSE EVENTS IN PATIENTS WITH AUTOIMMUNE DISEASE
Feher A, Boutagy N, Oikonomou E, Miller E, Sinusas A, Hinchcliff M. IMPAIRED CORONARY FLOW RESERVE ON 82RUBIDIUM POSITRON EMISSION TOMOGRAPHY IMAGING PREDICTS ADVERSE EVENTS IN PATIENTS WITH AUTOIMMUNE DISEASE. Journal Of The American College Of Cardiology 2020, 75: 1726. DOI: 10.1016/s0735-1097(20)32353-6.Peer-Reviewed Original Research
2019
Upper reference limits of transient ischemic dilation ratio for different protocols on new-generation cadmium zinc telluride cameras: A report from REFINE SPECT registry
Hu LH, Sharir T, Miller RJH, Einstein AJ, Fish MB, Ruddy TD, Dorbala S, Di Carli M, Kaufmann PA, Sinusas AJ, Miller EJ, Bateman TM, Betancur J, Germano G, Liang JX, Commandeur F, Azadani PN, Gransar H, Otaki Y, Tamarappoo BK, Dey D, Berman DS, Slomka PJ. Upper reference limits of transient ischemic dilation ratio for different protocols on new-generation cadmium zinc telluride cameras: A report from REFINE SPECT registry. Journal Of Nuclear Cardiology 2019, 27: 1180-1189. PMID: 31087268, PMCID: PMC6851400, DOI: 10.1007/s12350-019-01730-y.Peer-Reviewed Original ResearchConceptsTransient ischemic dilationUpper reference limitReference limitsMulticenter registrySupine positionTransient ischemic dilation ratioCoronary artery diseaseCadmium zinc telluride cameraQuantitative perfusion SPECT softwareREFINE SPECT registryIschemic dilationArtery diseasePerfusion findingsMyocardial perfusionD-SPECTRegistryLower likelihoodSPECT softwareTelluride cameraRadiotracerDilation ratioDifferent protocolsPatientsPerfusionDiseasePET-Based Imaging of Ischemic Heart Disease
Chen K, Miller EJ, Sadeghi MM. PET-Based Imaging of Ischemic Heart Disease. PET Clinics 2019, 14: 211-221. PMID: 30826019, PMCID: PMC6426655, DOI: 10.1016/j.cpet.2018.12.003.Peer-Reviewed Original ResearchMeSH KeywordsComputed Tomography AngiographyCoronary Artery DiseaseCoronary CirculationCost-Benefit AnalysisFractional Flow Reserve, MyocardialHumansMultimodal ImagingMyocardial IschemiaMyocardial Perfusion ImagingPositron-Emission TomographyPrognosisRadiopharmaceuticalsSensitivity and SpecificityTomography, Emission-Computed, Single-PhotonConceptsIschemic heart diseaseHeart diseaseCoronary artery diseaseCardiac nuclear imagingCoronary flow reserveAtherosclerotic plaque vulnerabilityMyocardial blood flowCT myocardial perfusionArtery diseaseIschemic cardiomyopathyMicrovascular diseaseVascular calcificationFlow reserveVascular remodelingMyocardial viabilityPlaque vulnerabilityBlood flowMyocardial perfusionMolecular imaging toolDiseaseNuclear imagingImaging toolPETImagingPrognosis
2008
Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart
Miller EJ, Li J, Leng L, McDonald C, Atsumi T, Bucala R, Young LH. Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart. Nature 2008, 451: 578-582. PMID: 18235500, DOI: 10.1038/nature06504.Peer-Reviewed Original ResearchMeSH KeywordsAMP-Activated Protein KinasesAnimalsAntigens, Differentiation, B-LymphocyteCoronary Artery DiseaseEnzyme ActivationGenetic Predisposition to DiseaseGenotypeGlucoseHistocompatibility Antigens Class IIHumansHypoxiaMacrophage Migration-Inhibitory FactorsMiceMultienzyme ComplexesMyocardial IschemiaMyocardial Reperfusion InjuryMyocardiumPolymorphism, GeneticPromoter Regions, GeneticProtein Serine-Threonine KinasesRatsSignal TransductionConceptsIschemic heartMacrophage migration inhibitory factorLower MIF levelsCoronary artery diseaseIschemic heart diseaseMigration inhibitory factorPotential risk markerMIF levelsArtery diseaseRisk markersHeart diseaseIschemic stressCytokine MIFInhibitory factorGlucose uptakePotential drug targetsDiseaseHeartDrug targetsCellular stress responseAMPKMaster regulatorNew studiesPatientsAtherosclerosis
2005
AMPK – A pivotal rheostat in the control of cardiac metabolism
Miller E, Russell R, Li J, Young L. AMPK – A pivotal rheostat in the control of cardiac metabolism. Drug Discovery Today Disease Mechanisms 2005, 2: 93-100. DOI: 10.1016/j.ddmec.2005.05.008.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMyocardial stress responseRegulation of AMPKProtein kinaseCentral regulatorStress responseAMPKNon-metabolic actionsCoronary artery diseaseNovel cardioprotective strategiesType 2 diabetesPotential novel approachArtery diseaseCardioprotective strategiesCardiac metabolismMetabolic actionsPossible roleKinaseRheostatRegulatorRegulationMetabolismDiabetesDisease