2024
The Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0).
Miller R, Lemley M, Shanbhag A, Ramirez G, Liang J, Builoff V, Kavanagh P, Sharir T, Hauser M, Ruddy T, Fish M, Bateman T, Acampa W, Einstein A, Dorbala S, Di Carli M, Feher A, Miller E, Sinusas A, Halcox J, Martins M, Kaufmann P, Dey D, Berman D, Slomka P. The Updated Registry of Fast Myocardial Perfusion Imaging with Next-Generation SPECT (REFINE SPECT 2.0). Journal Of Nuclear Medicine 2024, 65: 1795-1801. PMID: 39362762, PMCID: PMC11533915, DOI: 10.2967/jnumed.124.268292.Peer-Reviewed Original ResearchCoronary artery calciumCT attenuation correction imagesStress total perfusion deficitMyocardial perfusion imagingTotal perfusion deficitAttenuation correction imagesPerfusion imagingREFINE SPECTImprove prediction of adverse outcomesPerfusion deficitsSPECT myocardial perfusion imagingIncreased risk of MACEPredictive of adverse outcomesMedian follow-upInvasive coronary angiographyRisk of MACEAdverse cardiovascular eventsCAC scoreExperience MACECoronary angiographyArtery calciumInternational registryCardiovascular eventsFollow-upClinical data
2020
Prognostically safe stress-only single-photon emission computed tomography myocardial perfusion imaging guided by machine learning: report from REFINE SPECT
Hu LH, Miller RJH, Sharir T, Commandeur F, Rios R, Einstein AJ, Fish MB, Ruddy TD, Kaufmann PA, Sinusas AJ, Miller EJ, Bateman TM, Dorbala S, Di Carli M, Liang JX, Eisenberg E, Dey D, Berman DS, Slomka PJ. Prognostically safe stress-only single-photon emission computed tomography myocardial perfusion imaging guided by machine learning: report from REFINE SPECT. European Heart Journal - Cardiovascular Imaging 2020, 22: 705-714. PMID: 32533137, DOI: 10.1093/ehjci/jeaa134.Peer-Reviewed Original ResearchConceptsMajor adverse cardiac eventsPhysician interpretationMACE rateCancellation rateTomography myocardial perfusion imagingAdverse cardiac eventsInternational multicentre registryCause mortality ratesMyocardial perfusion imagingCurrent clinical approachesSingle photon emissionMulticentre registryCardiac eventsClinical dataMortality ratePerfusion imagingClinical approachPatientsML thresholdsRadiation exposureMPI scansPhoton emissionML scoreMLSafety
2018
Rationale and design of the REgistry of Fast Myocardial Perfusion Imaging with NExt generation SPECT (REFINE SPECT)
Slomka PJ, Betancur J, Liang JX, Otaki Y, Hu LH, Sharir T, Dorbala S, Di Carli M, Fish MB, Ruddy TD, Bateman TM, Einstein AJ, Kaufmann PA, Miller EJ, Sinusas AJ, Azadani PN, Gransar H, Tamarappoo BK, Dey D, Berman DS, Germano G. Rationale and design of the REgistry of Fast Myocardial Perfusion Imaging with NExt generation SPECT (REFINE SPECT). Journal Of Nuclear Cardiology 2018, 27: 1010-1021. PMID: 29923104, PMCID: PMC6301135, DOI: 10.1007/s12350-018-1326-4.Peer-Reviewed Original ResearchMeSH KeywordsAgedArtificial IntelligenceAutomationCoronary AngiographyCoronary Artery DiseaseData CollectionDatabases, FactualFemaleFollow-Up StudiesHumansImage Processing, Computer-AssistedMachine LearningMaleMiddle AgedMyocardial Perfusion ImagingPrognosisRegistriesReproducibility of ResultsSoftwareTomography, Emission-Computed, Single-PhotonConceptsMyocardial perfusion imagingPharmacologic stressMajor adverse cardiac eventsAdverse cardiac eventsRevascularization resultsMulticenter registryCardiac eventsClinical variablesPrognostic outcomesResultsTo dateClinical dataPrognostic dataDiagnostic cohortSPECT-MPIImaging variablesMyocardial perfusionPrognostic cohortPerfusion imagingPatientsRegistryArtificial intelligence toolsNew artificial intelligence toolsQuantitative softwareCohortClinical image database