2024
Immunological and microbial shifts in the aging rhesus macaque lung during nontuberculous mycobacterial infection
Cinco I, Napier E, Rhoades N, Davies M, Allison D, Kohama S, Bermudez L, Winthrop K, Fuss C, Spindel E, Messaoudi I. Immunological and microbial shifts in the aging rhesus macaque lung during nontuberculous mycobacterial infection. MBio 2024, 15: e00829-24. PMID: 38771046, PMCID: PMC11237422, DOI: 10.1128/mbio.00829-24.Peer-Reviewed Original ResearchConceptsNTM pulmonary diseaseIncreased disease severityNontuberculous mycobacteriaDisease severityBacterial DNAAged animalsAntigen-specific T cellsPulmonary diseaseAssociated with increased disease severityDysregulated macrophage responsePersistence of bacterial DNALack of animal modelsRhesus macaquesSingle-cell RNA sequencingNontuberculous mycobacterial infectionsImmune cell infiltrationRhesus macaque modelBacterial loadAged rhesus macaquesTesting novel therapeuticsRight caudal lobeLower respiratory microbiomeYears of ageMAH infectionMicrobial communitiesTransthoracic Echocardiography–Guided Placement of a Pulmonary Artery Catheter in a Patient With a Known Persistent Left but Unknown Absent Right Superior Vena Cava
Leclerc J, Clemes R, Fuss C, Macon C, Schulman P. Transthoracic Echocardiography–Guided Placement of a Pulmonary Artery Catheter in a Patient With a Known Persistent Left but Unknown Absent Right Superior Vena Cava. Circulation Cardiovascular Imaging 2024, 17: e016301. PMID: 38469718, DOI: 10.1161/circimaging.123.016301.Peer-Reviewed Original Research
2023
Imaging Acute and Chronic Cardiac Complications of COVID-19 and after COVID-19 Vaccination.
Sánchez Tijmes F, Marschner C, de Matos J, Urzua Fresno C, Gutiérrez Chacoff J, Thavendiranathan P, Fuss C, Hanneman K. Imaging Acute and Chronic Cardiac Complications of COVID-19 and after COVID-19 Vaccination. Radio Graphics 2023, 43: e230044. PMID: 37616171, DOI: 10.1148/rg.230044.Peer-Reviewed Original ResearchConceptsLate gadolinium enhancementGadolinium enhancementCardiac MRICOVID-19 vaccinePattern of late gadolinium enhancementCardiac complications of COVID-19MRNA-based COVID-19 vaccinesPresence of cardiovascular diseaseStress-induced cardiomyopathyMultimodality cardiac imagingBasal inferolateral wallMinority of patientsPersistent cardiac symptomsAdverse cardiovascular eventsComplications of COVID-19Chronic cardiac complicationsManifestations of COVID-19Potential mechanisms of injuryMechanism of injuryCardiovascular manifestations of COVID-19Messenger ribonucleic acidAcute COVID-19Cardiac symptomsCardiovascular manifestationsImaging findingsOpen-Label Trial of Amikacin Liposome Inhalation Suspension in Mycobacterium abscessus Lung Disease
Siegel S, Griffith D, Philley J, Brown-Elliott B, Brunton A, Sullivan P, Fuss C, Strnad L, Wallace R, Winthrop K. Open-Label Trial of Amikacin Liposome Inhalation Suspension in Mycobacterium abscessus Lung Disease. CHEST Journal 2023, 164: 846-859. PMID: 37419144, PMCID: PMC10645596, DOI: 10.1016/j.chest.2023.05.036.Peer-Reviewed Original ResearchConceptsAmikacin liposome inhalation suspensionAmikacin resistanceCulture conversionInhalation suspensionMycobacterium abscessus lung diseasePresence of macrolide resistanceEnd pointsMicrobiological end pointsMonthly sputum culturesSputum culture conversionTreatment-refractory diseaseOpen-label protocolSecondary end pointsOpen-label trialCohort of patientsCavitary diseaseSputum culturePretreatment isolatesM abscessusOpen-labelOral antimicrobialsParenteral antibioticsCompanion therapyMacrolide resistanceMultidrug therapy
2022
Pulmonary Vascular Complication Associated With Coronavirus Infection and Role of Lung Resection
Wong L, Sukumar M, Fuss C, Thanawala R. Pulmonary Vascular Complication Associated With Coronavirus Infection and Role of Lung Resection. The Annals Of Thoracic Surgery 2022, 115: e89-e91. PMID: 35472408, PMCID: PMC9035613, DOI: 10.1016/j.athoracsur.2022.04.016.Peer-Reviewed Original ResearchConceptsPulmonary artery pseudoaneurysmArtery pseudoaneurysmAcute hypoxic respiratory failureHypoxic respiratory failureThoracic surgical proceduresLife-threatening complicationsComplication of ruptureCOVID-19 pneumoniaLung resectionStress cardiomyopathyRespiratory failurePulmonary vasculaturePerioperative planningSurgical proceduresPseudoaneurysmGranulomaPatientsCoronavirus infectionCOVID-19BacteremiaResectionHemothoraxBleedingCardiomyopathyPneumoniaFunctional, transcriptional, and microbial shifts associated with healthy pulmonary aging in rhesus macaques
Rhoades N, Davies M, Lewis S, Cinco I, Kohama S, Bermudez L, Winthrop K, Fuss C, Mattison J, Spindel E, Messaoudi I. Functional, transcriptional, and microbial shifts associated with healthy pulmonary aging in rhesus macaques. Cell Reports 2022, 39: 110725. PMID: 35443183, PMCID: PMC9096119, DOI: 10.1016/j.celrep.2022.110725.Peer-Reviewed Original ResearchConceptsT cellsCD8<sup>+</sup> T cellsCD8<sup>+</sup> TRhesus macaque modelPulmonary function testsSevere respiratory infectionsSeverity of respiratory diseasePulmonary ageCross-sectional studyMacaque modelInfiltrating macrophagesImmunological landscapeRespiratory infectionsImpact of ageComprehensive cross-sectional studyIncreased riskAge-related changesFunction testsAged animalsIncreased prevalenceHealthy humansRespiratory tractRhesus macaquesConsequence of agingLung
2021
Outcomes of Resectional Thoracic Surgery for the Treatment of Pulmonary Nontuberculous Mycobacterial Disease in 105 Patients in the United States
Ku J, Siegel S, Philley J, Schipper P, Thanawala R, Hendrick M, Sigler C, Strnad L, McShane P, Griffith D, Tieu B, Caccitolo J, Fuss C, Le A, Winthrop K. Outcomes of Resectional Thoracic Surgery for the Treatment of Pulmonary Nontuberculous Mycobacterial Disease in 105 Patients in the United States. CHEST Journal 2021, 161: 365-369. PMID: 34390707, DOI: 10.1016/j.chest.2021.08.004.Peer-Reviewed Original Research
2020
Asymptomatic COVID-19: What the Neuroradiologist Needs to Know about Pulmonary Manifestations
Barajas R, Rufener G, Starkey J, Duncan T, Fuss C. Asymptomatic COVID-19: What the Neuroradiologist Needs to Know about Pulmonary Manifestations. American Journal Of Neuroradiology 2020, 41: 966-968. PMID: 32409313, PMCID: PMC7342749, DOI: 10.3174/ajnr.a6561.Peer-Reviewed Original Research
2018
VIDEO: Rethinking "Mural Thickening:" Vasculitis or Aortic Dissection?
Harrington C, Brescia A, Tieu B, Fuss C. VIDEO: Rethinking "Mural Thickening:" Vasculitis or Aortic Dissection? American Journal Of Roentgenology 2018, 210: w240-w241. PMID: 29683349, DOI: 10.2214/ajr.17.19090.Peer-Reviewed Original Research