2024
Immunological and microbial shifts in the aging rhesus macaque lung during nontuberculous mycobacterial infection
Cinco I, Napier E, Rhoades N, Davies M, Allison D, Kohama S, Bermudez L, Winthrop K, Fuss C, Spindel E, Messaoudi I. Immunological and microbial shifts in the aging rhesus macaque lung during nontuberculous mycobacterial infection. MBio 2024, 15: e00829-24. PMID: 38771046, PMCID: PMC11237422, DOI: 10.1128/mbio.00829-24.Peer-Reviewed Original ResearchConceptsNTM pulmonary diseaseIncreased disease severityNontuberculous mycobacteriaDisease severityBacterial DNAAged animalsAntigen-specific T cellsPulmonary diseaseAssociated with increased disease severityDysregulated macrophage responsePersistence of bacterial DNALack of animal modelsRhesus macaquesSingle-cell RNA sequencingNontuberculous mycobacterial infectionsImmune cell infiltrationRhesus macaque modelBacterial loadAged rhesus macaquesTesting novel therapeuticsRight caudal lobeLower respiratory microbiomeYears of ageMAH infectionMicrobial communities
2020
Surgical Outcome of Resectional Thoracic Surgery for the Treatment of Nontuberculous Mycobacterial Pulmonary Disease in 98 U.S. Patients
Ku J, Siegel S, Schipper P, Tieu B, Hendrick M, Sigler C, Strnad L, Fuss C, Philley J, Winthrop K, Caccitolo J. Surgical Outcome of Resectional Thoracic Surgery for the Treatment of Nontuberculous Mycobacterial Pulmonary Disease in 98 U.S. Patients. 2020, a4497-a4497. DOI: 10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a4497.Peer-Reviewed Original Research