2014
A clinical decision model for selecting the most appropriate therapy for uncomplicated chronic dissections of the descending aorta
Hogendoorn W, Hunink MG, Schlösser FJ, Moll FL, Sumpio BE, Muhs BE. A clinical decision model for selecting the most appropriate therapy for uncomplicated chronic dissections of the descending aorta. Journal Of Vascular Surgery 2014, 60: 20-30. PMID: 24613191, DOI: 10.1016/j.jvs.2014.01.054.Peer-Reviewed Original ResearchConceptsInitial aortic diameterOptimal medical therapyOpen surgical repairHigh-risk patientsLow-risk patientsLarger aortic diametersAortic diameterPreferred treatment optionElderly patientsClinical decision modelDecision analysis modelYounger patientsPatient cohortTreatment optionsChronic Stanford type B aortic dissectionStanford type B aortic dissectionImmediate open surgical repairType B aortic dissectionAortic diameter thresholdSmaller aortic diametersB aortic dissectionEndovascular aortic repairMaximum aortic diameterMarkov decision analysis modelBest available evidence
2013
Thoracic endovascular aortic repair with the chimney graft technique
Hogendoorn W, Schlösser FJ, Moll FL, Sumpio BE, Muhs BE. Thoracic endovascular aortic repair with the chimney graft technique. Journal Of Vascular Surgery 2013, 58: 502-511. PMID: 23697513, DOI: 10.1016/j.jvs.2013.03.043.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAorta, ThoracicAortic DiseasesBlood Vessel ProsthesisBlood Vessel Prosthesis ImplantationChildElective Surgical ProceduresEmergenciesEndoleakEndovascular ProceduresFemaleHumansMaleMiddle AgedRisk FactorsStentsStrokeTime FactorsTreatment OutcomeVascular PatencyYoung AdultConceptsThoracic endovascular aortic repairChimney graft techniqueEndovascular aortic repairElective settingChimney stentsChimney techniqueAortic repairTreatment strategiesGraft techniqueLeft common carotid arteryAortic arch branchesOverall perioperative mortalityAortic side branchesLeft subclavian arteryThoracic aortic pathologyViable treatment optionCommon carotid arterySelf-expandable stentsBalloon-expandable stentsPerioperative mortalityAortic pathologySubclavian arteryArch branchesBrachiocephalic arteryEmergent setting
2010
Endograft Collapse after Thoracic Endovascular Aortic Repair
Jonker FH, Schlosser FJ, Geirsson A, Sumpio BE, Moll FL, Muhs BE. Endograft Collapse after Thoracic Endovascular Aortic Repair. Journal Of Endovascular Therapy 2010, 17: 725-734. PMID: 21142480, DOI: 10.1583/10-3130.1.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAorta, ThoracicAortic Aneurysm, ThoracicAortic DiseasesAortic DissectionAortographyBlood Vessel ProsthesisBlood Vessel Prosthesis ImplantationEndovascular ProceduresFemaleHumansKaplan-Meier EstimateMaleMiddle AgedPostoperative ComplicationsProsthesis DesignProsthesis FailureReoperationRisk AssessmentRisk FactorsStentsTime FactorsTreatment OutcomeYoung AdultConceptsEndograft collapseEndovascular aortic repairAortic injuryAortic repairChronic type B aortic dissectionTraumatic thoracic aortic injuryThoracic endovascular aortic repairType B aortic dissectionProcedure-related deathsThoracic aortic injuryTraumatic aortic injuryCochrane Library CENTRALB aortic dissectionMedian time intervalLong-term outcomesStent-graft collapseAsymptomatic patientsEndovascular repairAortic dissectionAortic archTEVARCurrent endovascular devicesExcessive oversizingPatientsOptimal management
2008
Synergistic Effect of Cool/Thaw Cycles on Vascular Cells in an In Vitro Model of Cryoplasty
Yiu WK, Cheng SW, Sumpio BE. Synergistic Effect of Cool/Thaw Cycles on Vascular Cells in an In Vitro Model of Cryoplasty. Journal Of Vascular And Interventional Radiology 2008, 19: 925-930. PMID: 18503909, DOI: 10.1016/j.jvir.2008.02.007.Peer-Reviewed Original ResearchConceptsSmooth muscle cellsAkt activationEndothelial cellsApoptotic smooth muscle cellsActivation of AktBovine aortic smooth muscle cellsAortic smooth muscle cellsSurvival responseDeoxynucleotidyl transferase-mediated dUTP nick end labelingFetal bovine serumTerminal deoxynucleotidyl transferase-mediated dUTP nick end labelingTransferase-mediated dUTP nick end labelingImmunoblot analysisDUTP nick end labelingHigher apoptotic rateVascular cells
2007
Direct comparison of endothelial cell and smooth muscle cell response to supercooling and rewarming
Yiu WK, Cheng SW, Sumpio BE. Direct comparison of endothelial cell and smooth muscle cell response to supercooling and rewarming. Journal Of Vascular Surgery 2007, 46: 557-564.e2. PMID: 17826245, DOI: 10.1016/j.jvs.2007.04.072.Peer-Reviewed Original ResearchAnimalsAorta, ThoracicApoptosisBlotting, WesternCattleCell ProliferationCells, CulturedCryopreservationDensitometryEndothelial CellsEnzyme ActivationIn Situ Nick-End LabelingMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Muscle, Smooth, VascularPhosphorylationProto-Oncogene Proteins c-aktRewarming
2006
Vascular Smooth Muscle Cell Apoptosis Induced by “Supercooling” and Rewarming
Yiu WK, Cheng SW, Sumpio BE. Vascular Smooth Muscle Cell Apoptosis Induced by “Supercooling” and Rewarming. Journal Of Vascular And Interventional Radiology 2006, 17: 1971-1977. PMID: 17185696, DOI: 10.1097/01.rvi.0000244868.65867.fb.Peer-Reviewed Original Research
2005
Resveratrol inhibits vascular smooth muscle cell proliferation and induces apoptosis
Poussier B, Cordova AC, Becquemin JP, Sumpio BE. Resveratrol inhibits vascular smooth muscle cell proliferation and induces apoptosis. Journal Of Vascular Surgery 2005, 42: 1190-1190.e14. PMID: 16376213, DOI: 10.1016/j.jvs.2005.08.014.Peer-Reviewed Original ResearchMeSH KeywordsAngiogenesis InhibitorsAnimalsAnimals, NewbornAntioxidantsAorta, ThoracicApoptosisBlotting, WesternCattleCell ProliferationCells, CulturedDNADose-Response Relationship, DrugFlow CytometryIn Situ Nick-End LabelingIn Vitro TechniquesMuscle, Smooth, VascularProliferating Cell Nuclear AntigenResveratrolStilbenesConceptsSmooth muscle cell proliferationMuscle cell proliferationVascular smooth muscle cell proliferationDose-dependent mannerSMC proliferationCell proliferationG1-S phaseBeneficial effectsFrench paradoxDose-dependent apoptotic effectTerminal deoxynucleotidyl transferase-mediated dUTP-biotin nickTransferase-mediated dUTP-biotin nickCardiovascular death ratesRed wine intakeRed wine consumptionEffects of resveratrolAortic SMC proliferationEnd labeling stainingVascular SMC proliferationDUTP-biotin nickMajor polyphenol componentHealthy life styleCell cycle analysisCardiovascular mortalityFlow-activated cell sorting
2001
Cyclic strain activates the pro-survival Akt protein kinase in bovine aortic smooth muscle cells
Chen A, Gortler D, Kilaru S, Araim O, Frangos S, Sumpio B. Cyclic strain activates the pro-survival Akt protein kinase in bovine aortic smooth muscle cells. Surgery 2001, 130: 378-381. PMID: 11490374, DOI: 10.1067/msy.2001.116668.Peer-Reviewed Original ResearchConceptsBovine aortic smooth muscle cellsAortic smooth muscle cellsSmooth muscle cellsProtein kinaseSerine/threonine protein kinaseThreonine protein kinasePro-survival functionAkt protein kinasePro-survival Akt kinaseMuscle cellsPhosphorylation of AktPlatelet-derived growth factorInhibition of apoptosisAkt kinasePrevalence of apoptosisArterial endothelial cellsWestern blot analysisCell survivalAkt phosphorylationKinaseBlot analysisApoptosisCyclic strainPhosphorylationArterial SMC proliferationCyclic Stretch Induces the Expression of Vascular Endothelial Growth Factor in Vascular Smooth Muscle Cells
Smith JD, Davies N, Willis AI, Sumpio BE, Zilla P. Cyclic Stretch Induces the Expression of Vascular Endothelial Growth Factor in Vascular Smooth Muscle Cells. Endothelium 2001, 8: 41-48. PMID: 11409850, DOI: 10.3109/10623320109063156.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAorta, ThoracicCattleCells, CulturedCoculture TechniquesCulture MediaEndothelial Growth FactorsEndothelium, VascularGene Expression RegulationLymphokinesMuscle, Smooth, VascularPhosphorylationReceptor Protein-Tyrosine KinasesReceptors, Growth FactorReceptors, Vascular Endothelial Growth FactorStress, MechanicalVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsVasodilationConceptsVascular smooth muscle cellsVascular endothelial growth factorSmooth muscle cellsEndothelial growth factorExposure of VSMCsMuscle cellsGrowth factorMigration of ECsBovine vascular smooth muscle cellsSteady-state levelsCyclic stretchNormal endothelial cell functionEndothelial cell functionVEGF receptor KDRRelease of VEGFVEGF receptor phosphorylationVEGF secretionMRNA steady-state levelsVEGF receptorsReceptor KDRVEGF mRNACell functionReceptor phosphorylationSignificant increaseEC survival
1997
Regulation of tPA in endothelial cells exposed to cyclic strain: role of CRE, AP-2, and SSRE binding sites
Sumpio B, Chang R, Xu W, Wang X, Du W. Regulation of tPA in endothelial cells exposed to cyclic strain: role of CRE, AP-2, and SSRE binding sites. American Journal Of Physiology 1997, 273: c1441-c1448. PMID: 9374627, DOI: 10.1152/ajpcell.1997.273.5.c1441.Peer-Reviewed Original ResearchAnimalsAorta, ThoracicBase SequenceBinding SitesCattleCell CycleCell NucleusCells, CulturedChloramphenicol O-AcetyltransferaseCyclic AMP Response Element-Binding ProteinDNA-Binding ProteinsEndothelium, VascularGene Expression Regulation, EnzymologicHumansKineticsMutagenesis, Site-DirectedOligodeoxyribonucleotidesPromoter Regions, GeneticRecombinant Fusion ProteinsStress, MechanicalTime FactorsTissue Plasminogen ActivatorTranscription Factor AP-2Transcription FactorsTransfectionExposure of endothelial cells to cyclic strain induces elevations of cytosolic Ca2+ concentration through mobilization of intracellular and extracellular pools
ROSALES O, ISALES C, BARRETT P, BROPHY C, SUMPIO B. Exposure of endothelial cells to cyclic strain induces elevations of cytosolic Ca2+ concentration through mobilization of intracellular and extracellular pools. Biochemical Journal 1997, 326: 385-392. PMID: 9291109, PMCID: PMC1218682, DOI: 10.1042/bj3260385.Peer-Reviewed Original ResearchConceptsMicroM GdCl3Endothelial cellsIP3 formationLate-phase componentsInitiation of stretchExtracellular poolConfluent bovine aortic endothelial cellsMobilization of intracellularAortic endothelial cellsBovine aortic endothelial cellsNM charybdotoxinCycles/minIP3 generationIntracellular Ca2Sustained phaseCytosolic Ca2Confluent endothelial cellsBenzohydroquinoneFree mediumTemporal relationshipMicroM NiCl2Ca2PreincubationCellsInitial rise
1996
Involvement of rho p21 in Cyclic Strain-Induced Tyrosine Phosphorylation of Focal Adhesion Kinase (pp125FAK), Morphological Changes and Migration of Endothelial Cells
Yano Y, Saito Y, Narumiya S, Sumpio B. Involvement of rho p21 in Cyclic Strain-Induced Tyrosine Phosphorylation of Focal Adhesion Kinase (pp125FAK), Morphological Changes and Migration of Endothelial Cells. Biochemical And Biophysical Research Communications 1996, 224: 508-515. PMID: 8702419, DOI: 10.1006/bbrc.1996.1057.Peer-Reviewed Original ResearchAdenosine Diphosphate RiboseADP Ribose TransferasesAnimalsAorta, ThoracicBotulinum ToxinsCattleCell Adhesion MoleculesCell MovementCells, CulturedCytoskeletal ProteinsEndothelium, VascularFocal Adhesion Kinase 1Focal Adhesion Protein-Tyrosine KinasesGTP-Binding ProteinsMitomycinsPaxillinPhosphoproteinsPhosphorylationPhosphotyrosineProtein-Tyrosine KinasesRho GTP-Binding ProteinsStress, Mechanical
1993
Phospholipase C: A Putative Mechanotransducer for Endothelial Cell Response to Acute Hemodynamic Changes
Brophy CM, Mills I, Rosales O, Isales C, Sumpio BE. Phospholipase C: A Putative Mechanotransducer for Endothelial Cell Response to Acute Hemodynamic Changes. Biochemical And Biophysical Research Communications 1993, 190: 576-581. PMID: 8427600, DOI: 10.1006/bbrc.1993.1087.Peer-Reviewed Original ResearchConceptsEndothelial cellsAcute hemodynamic changesPhospholipase C activationHemodynamic changesProduction of inositolAcute decreaseAcute increaseIP3 generationEndothelial cell responsesCell responsesIP3 productionPutative mechanotransducersTransient increaseSpecific signal transduction pathwaysOngoing studiesCardiac cycleC activationSignal transduction pathwaysTransduction pathways
1988
Prostacyclin synthetic activity in cultured aortic endothelial cells undergoing cyclic mechanical deformation.
Sumpio BE, Banes AJ. Prostacyclin synthetic activity in cultured aortic endothelial cells undergoing cyclic mechanical deformation. Surgery 1988, 104: 383-9. PMID: 3135629.Peer-Reviewed Original ResearchAlterations in aortic endothelial cell morphology and cytoskeletal protein synthesis during cyclic tensional deformation
Sumpio B, Banes A, Buckley M, Johnson G. Alterations in aortic endothelial cell morphology and cytoskeletal protein synthesis during cyclic tensional deformation. Journal Of Vascular Surgery 1988, 7: 130-138. PMID: 3336119, DOI: 10.1016/0741-5214(88)90386-2.Peer-Reviewed Original Research
1987
Mechanical stress stimulates aortic endothelial cells to proliferate
Sumpio B, Banes A, Levin L, Johnson G. Mechanical stress stimulates aortic endothelial cells to proliferate. Journal Of Vascular Surgery 1987, 6: 252-256. PMID: 3625881, DOI: 10.1016/0741-5214(87)90037-1.Peer-Reviewed Original Research