2003
Abdominal aortic aneurysm in association with a congenital pelvic horseshoe kidney: sentinel report and technical consideration
Renzulli JF, Borromeo JR, Barkhordarian S, Sumpio BE. Abdominal aortic aneurysm in association with a congenital pelvic horseshoe kidney: sentinel report and technical consideration. Vascular Medicine 2003, 8: 197-199. PMID: 14989561, DOI: 10.1191/1358863x03vm495cr.Peer-Reviewed Original Research
1995
Endothelins: polyfunctional cytokines.
McMillen MA, Sumpio BE. Endothelins: polyfunctional cytokines. Journal Of The American College Of Surgeons 1995, 180: 621-37. PMID: 7749544.Peer-Reviewed Original ResearchAdrenal GlandsAmino Acid SequenceCell Transformation, NeoplasticCytokinesDigestive SystemEndothelinsEndothelium, VascularHumansInsulinKidneyLiverLungMacrophagesMolecular Sequence DataMonocytesMuscle, Smooth, VascularMyocardiumNeutrophilsParathyroid GlandsPeripheral Vascular DiseasesPituitary Gland, AnteriorProtein BindingReceptors, EndothelinThyroid Gland
1993
Captopril renal scintigraphy: A new standard for predicting outcome after renal revascularization
Meier G, Sumpio B, Setaro J, Black H, Gusberg R. Captopril renal scintigraphy: A new standard for predicting outcome after renal revascularization. Journal Of Vascular Surgery 1993, 17: 280-287. PMID: 8433423, DOI: 10.1016/0741-5214(93)90413-g.Peer-Reviewed Original ResearchConceptsCaptopril renal scintigraphyCaptopril-induced changesRenal revascularizationHypertension responseBlood pressureAmerican Heart Association criteriaDose of captoprilGlomerular filtration rateCessation of administrationNuclear medicine techniquesCaptopril administrationStandard renogramRenovascular diseaseBalloon angioplastyVascular toneRenal scintigraphyFiltration rateBaseline scanRevascularizationStudy groupAssociation criteriaPatientsEnzyme inhibitorsMedicine techniquesRenogram
1991
Nephrotoxic potential of FK 506.
Sumpio BE, Phan S. Nephrotoxic potential of FK 506. Transplantation Proceedings 1991, 23: 2789-90. PMID: 1721278.Peer-Reviewed Original ResearchAmelioration of renal ischemic injury by phosphocreatine
Rodriguez R, Stepke M, Maitz S, Cuono C, Sumpio B. Amelioration of renal ischemic injury by phosphocreatine. Journal Of Surgical Research 1991, 51: 271-274. PMID: 1921364, DOI: 10.1016/0022-4804(91)90106-v.Peer-Reviewed Original ResearchConceptsRenal ischemic injuryInitial ischemic insultPerfusion of kidneysKrebs-bicarbonate solutionMin of normothermicMM phosphocreatineRenal functionIschemic injuryKidney functionIschemic insultRenal arteryVivo ischemiaWarm ischemiaKrebs solutionKidneyPhosphocreatineAddition of phosphocreatineIschemiaSignificant improvementRegeneration of ATPGFRArteryNormothermicUreterInjury
1990
Captopril renal scintigraphy—An advance in the detection and treatment of renovascular hypertension
Meier G, Sumpio B, Black H, Gusberg R. Captopril renal scintigraphy—An advance in the detection and treatment of renovascular hypertension. Journal Of Vascular Surgery 1990, 11: 770-777. DOI: 10.1016/0741-5214(90)90072-i.Peer-Reviewed Original ResearchConceptsCaptopril renal scintigraphyRenovascular hypertensionRenal scintigraphyDiethylenetriaminepentaacetic acid renal scanSignificant renal artery stenosisRenal scan resultsNoninvasive techniqueRenal artery stenosisDetection of patientsNew noninvasive techniqueHypertension responseUnderwent revascularizationBypass surgerySurgical bypassAbnormal findingsRenal scanScintigraphy scanArtery stenosisInterventional therapyScan outcomesHypertensionDurable benefitRevascularizationScintigraphyPatientsCaptopril renal scintigraphy--an advance in the detection and treatment of renovascular hypertension.
Meier G, Sumpio B, Black H, Gusberg R. Captopril renal scintigraphy--an advance in the detection and treatment of renovascular hypertension. Journal Of Vascular Surgery 1990, 11: 770-6; discussion 776-7. PMID: 2101580, DOI: 10.1067/mva.1990.20329.Peer-Reviewed Original ResearchConceptsCaptopril renal scintigraphyRenovascular hypertensionRenal scintigraphyDiethylenetriaminepentaacetic acid renal scanSignificant renal artery stenosisRenal scan resultsNoninvasive techniqueRenal artery stenosisDetection of patientsNew noninvasive techniqueHypertension responseUnderwent revascularizationBypass surgerySurgical bypassAbnormal findingsRenal scanScintigraphy scanArtery stenosisInterventional therapyScan outcomesHypertensionDurable benefitRevascularizationScintigraphyPatients
1989
The influence of perfusate viscosity, RBC deformability and drag on the function of an isolated perfused rat kidney
Sumpio B, Upchurch G, Johnson G. The influence of perfusate viscosity, RBC deformability and drag on the function of an isolated perfused rat kidney. Journal Of Surgical Research 1989, 46: 4-8. PMID: 2915534, DOI: 10.1016/0022-4804(89)90174-1.Peer-Reviewed Original ResearchConceptsRenal functionMean renal arterial pressureRat kidneyKrebs-HCO3 bufferRenal arterial pressureReabsorption of sodiumArterial pressureUrine flowOrgan functionClinical interestHCO3- bufferPerfusate solutionHematocritBlood rheologyFunctional parametersPerfusate viscosityRBC deformabilityKidneyPerfusateDegrees CRBCsDrag-reducing agentsGFRCreatinineAgents
1988
Cyclosporine toxicity in the isolated perfused rat kidney.
Sumpio BE. Cyclosporine toxicity in the isolated perfused rat kidney. Transplantation Proceedings 1988, 20: 712-6. PMID: 3388509.Peer-Reviewed Original Research
1987
Mitochondrial Respiratory and Calcium Studies
SUMPIO B, BAUE A, CHAUDRY I. Mitochondrial Respiratory and Calcium Studies. Annals Of Surgery 1987, 206: 655-660. PMID: 3499878, PMCID: PMC1493310, DOI: 10.1097/00000658-198711000-00017.Peer-Reviewed Original ResearchConceptsRespiratory control ratioVerapamil pretreatmentTotal tissue Ca2Tissue ATP levelsCyA-induced nephrotoxicityCyA treatmentPharmacologic regimenRenal functionMitochondrial respiratory functionSimultaneous administrationCalcium studiesRespiratory functionKrebs bufferCortical mitochondriaMumol/Tissue Ca2Rat kidneyADP/O ratioCyANephrotoxicityATP levelsControl ratioVerapamilMitochondrial respiratoryCa2Treatment with verapamil and adenosine triphosphate-MgCl2 reduces cyclosporine nephrotoxicity.
Sumpio B, Baue A, Chaudry I. Treatment with verapamil and adenosine triphosphate-MgCl2 reduces cyclosporine nephrotoxicity. Surgery 1987, 101: 315-22. PMID: 2950608.Peer-Reviewed Original ResearchConceptsGlomerular filtration rateRenal perfusate flowTubular absorptionPerfusate flowUrine outputImmunosuppressive agentsVerapamil pretreatmentClearance periodMicrograms/ATP-MgCl2 treatmentControl clearance periodsUse of cyclosporineCombination of verapamilSerious side effectsTissue ATP levelsEffects of adenosineCyA treatmentCyA nephrotoxicityCyclosporine nephrotoxicityVerapamil treatmentTubular functionRenal flowNephrotoxic potentialFiltration rateATP-MgCl2Comparison of effects of ATP-MgCl2 and adenosine-MgCl2 on renal function following ischemia
Sumpio BE, Hull MJ, Baue AE, Chaudry IH. Comparison of effects of ATP-MgCl2 and adenosine-MgCl2 on renal function following ischemia. American Journal Of Physiology 1987, 252: r388-r393. PMID: 3492930, DOI: 10.1152/ajpregu.1987.252.2.r388.Peer-Reviewed Original ResearchConceptsRenal functionATP-MgCl2Warm ischemiaATP-MgCl2 treatmentKrebs-HCO3 bufferMM ATP-MgCl2Comparison of effectsNormothermic ischemiaTransient improvementIschemiaSalutary effectsControl valuesUrine samplesFunctional parametersKidneyMajor breakdown productAdenosineTreatmentBreakdown productsMmHgPerfusateMinAdministration
1986
Effects of ATP-MgCl2 and adenosine-MgCl2 administration on intracellular ATP levels in the kidney
Sumpio B, Hull M, Bauer A, Chaudry I. Effects of ATP-MgCl2 and adenosine-MgCl2 administration on intracellular ATP levels in the kidney. Biochimica Et Biophysica Acta 1986, 862: 303-308. PMID: 3778894, DOI: 10.1016/0005-2736(86)90232-4.Peer-Reviewed Original ResearchConceptsATP-MgCl2 administrationColloid oncotic pressureIntracellular ATPATP-MgCl2Exogenous administrationIntracellular ATP levelsRat kidneyOncotic pressureAdministrationTotal intracellular ATPPerfusate solutionKidneyIntracellular accumulationATP levelsAdenine nucleotidesSignificant accumulationATPPerfusate
1985
Renal handling of proteins in normal and disease states.
Sumpio B, Hayslett J. Renal handling of proteins in normal and disease states. QJM 1985, 57: 611-35. PMID: 4080952.Peer-Reviewed Original ResearchReduction of the drug-induced nephrotoxicity by ATP-MgCl2. 1. Effects on the cis-Diamminedichloroplatinum-treated isolated perfused kidneys
Sumpio B, Chaudry I, Baue A. Reduction of the drug-induced nephrotoxicity by ATP-MgCl2. 1. Effects on the cis-Diamminedichloroplatinum-treated isolated perfused kidneys. Journal Of Surgical Research 1985, 38: 429-437. PMID: 3872963, DOI: 10.1016/0022-4804(85)90058-7.Peer-Reviewed Original ResearchConceptsAcute renal failureATP-MgCl2Hr of perfusionCis-DiamminedichloroplatinumNephrotoxic effectsReabsorptive capacityCDDP treatmentRat kidneyATP-MgCl2 treatmentIsolated rat kidneyDrug-induced nephrotoxicityDirect nephrotoxic effectNew therapeutic modalitiesProximal tubule cellsCancer chemotherapeutic agentsCDDP therapyRenal failureMarked diuresisProtein reabsorptionTherapeutic modalitiesTubule cellsChemotherapeutic agentsMicrograms/KidneyMarked inhibitionReduction of the drug-induced nephrotoxicity by ATP-MgCl2. II. Effects on gentamicin-treated isolated perfused kidneys
Sumpio B, Chaudry I, Baue A. Reduction of the drug-induced nephrotoxicity by ATP-MgCl2. II. Effects on gentamicin-treated isolated perfused kidneys. Journal Of Surgical Research 1985, 38: 438-445. PMID: 3872964, DOI: 10.1016/0022-4804(85)90059-9.Peer-Reviewed Original ResearchConceptsDrug-induced nephrotoxicityGlomerular filtration rateRenal perfusate flowATP-MgCl2Filtration ratePerfusate flowMM ATP-MgCl2Prevention of nephrotoxicityGentamicin-induced nephrotoxicitySignificant clinical problemNon-pulsatile perfusionIsolated kidney preparationMin of perfusionHr of perfusionDose-dependent mannerTubular absorptionUrinary flowGentamicin treatmentProtein reabsorptionClinical problemNephrotoxicityPerfusate concentrationFractional clearanceClearance periodSodium absorptionAdenosine Triphosphate—Magnesium Chloride Ameliorates Reperfusion Injury Following Ischemia as Determined by Phosphorus Nuclear Magnetic Resonance
Sumpio B, Chaudry I, Baue A. Adenosine Triphosphate—Magnesium Chloride Ameliorates Reperfusion Injury Following Ischemia as Determined by Phosphorus Nuclear Magnetic Resonance. JAMA Surgery 1985, 120: 233-240. PMID: 3872113, DOI: 10.1001/archsurg.1985.01390260091013.Peer-Reviewed Original ResearchConceptsIntracellular acidosisPerfusate flowATP levelsAdenosine triphosphate-magnesium chlorideRenal ATP levelsMinutes of reperfusionTissue ATP levelsEffects of ischemiaAdenosine triphosphateML/minPostischemic administrationReperfusion injuryRenal ischemiaWarm ischemiaATP-MgCl2ReperfusionIschemiaInorganic phosphate peakIntracellular adenosine triphosphatePi peakRat kidneyAcidosisATP depletionMinutesMagnetic resonance
1984
Accelerated functional recovery of isolated rat kidney with ATP-MgCl2 after warm ischemia
Sumpio BE, Chaudry IH, Clemens MG, Baue AE. Accelerated functional recovery of isolated rat kidney with ATP-MgCl2 after warm ischemia. American Journal Of Physiology 1984, 247: r1047-r1053. PMID: 6334446, DOI: 10.1152/ajpregu.1984.247.6.r1047.Peer-Reviewed Original ResearchConceptsRenal perfusate flow rateMM ATP-MgCl2Min of perfusionIsolated rat kidneyATP-MgCl2Renal functionWarm ischemiaWhole kidney inulin clearanceRat kidneyAccelerated functional recoveryMin of reperfusionMin of ischemiaUrine flow rateTissue ATP levelsFractional absorptionFunctional recoveryNormothermic ischemiaIschemia resultsMin ischemiaPerfusate flow rateInulin clearanceEarly recoverySystemic effectsIschemiaSodium valuesRenal hydrolysis of absorbed protein: influence of load and lysosomal pH
Camargo MJ, Sumpio BE, Maack T. Renal hydrolysis of absorbed protein: influence of load and lysosomal pH. American Journal Of Physiology 1984, 247: f656-f664. PMID: 6093557, DOI: 10.1152/ajprenal.1984.247.4.f656.Peer-Reviewed Original ResearchConceptsNormal filtered loadEfflux of radioactivityRenal tubular cellsEffect of alkalinizationProtein absorption dropletsRenal catabolismNormal lysosomal functionLysosomotropic weak basesFiltered loadTubular cellsKidney 1Abnormal depositionRat kidneyKidneyAbsorption dropletsSaturable processIntracellular hydrolysisSaturable functionLysosomal functionPerfusateLysosomal pHLow uptake rateSephadex chromatographyReversible mannerHalf timesKinetics of Renal Catabolism of Absorbed Proteins: Influence of Lysosomal pH
Camargo M, Sumpio B, Maack T. Kinetics of Renal Catabolism of Absorbed Proteins: Influence of Lysosomal pH. Contributions To Nephrology 1984, 42: 19-29. PMID: 6099789, DOI: 10.1159/000409957.Peer-Reviewed Original Research