2007
Effects of different types of fluid shear stress on endothelial cell proliferation and survival
Kadohama T, Nishimura K, Hoshino Y, Sasajima T, Sumpio BE. Effects of different types of fluid shear stress on endothelial cell proliferation and survival. Journal Of Cellular Physiology 2007, 212: 244-251. PMID: 17323381, DOI: 10.1002/jcp.21024.Peer-Reviewed Original Research
2001
Intermittent Pneumatic Compression Devices – Physiological Mechanisms of Action
Chen AH, Frangos SG, Kilaru S, Sumpio BE. Intermittent Pneumatic Compression Devices – Physiological Mechanisms of Action. European Journal Of Vascular And Endovascular Surgery 2001, 21: 383-392. PMID: 11352511, DOI: 10.1053/ejvs.2001.1348.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomechanical PhenomenaBlood CirculationBlood VesselsGravity SuitsHumansVenous ThrombosisConceptsLower extremity arterial diseaseDeep venous thrombosisExtremity arterial diseaseImprovement of circulationUse of IPCExact physiological mechanismsCultured endothelial cellsVenous thrombosisVenous ulcersArterial diseaseLower extremitiesTherapeutic effectClinical utilityClinical relevanceClinical settingBeneficial effectsEndothelial cellsSubsequent biochemical changesPutative mechanismsBiochemical changesPhysiological mechanismsThrombosisUlcersPatientsLymphoedema
2000
Foot Ulcers
Sumpio BE. Foot Ulcers. New England Journal Of Medicine 2000, 343: 787-793. PMID: 10984568, DOI: 10.1056/nejm200009143431107.Peer-Reviewed Original ResearchMeSH KeywordsBiomechanical PhenomenaDiabetes ComplicationsFootFoot DeformitiesFoot UlcerGaitHumansIschemiaNervous System DiseasesRisk FactorsWound InfectionConceptsPrimary care physiciansComprehensive treatment protocolMajor amputationPedal woundsAggressive treatmentFoot complicationsCare physiciansFoot ulcersVascular diseaseEarly recognitionRisk factorsPatient educationBiomechanical abnormalitiesTreatment protocolPrevents infectionOptimal managementSkin integrityCareful assessmentMultidisciplinary approachInfectionUlcerationComplicationsUlcersAmputationManagement
1997
Tissue plasminogen activator-biologic perspective for surgeons.
Chang R, Powell RJ, Sumpio BE. Tissue plasminogen activator-biologic perspective for surgeons. Journal Of The American College Of Surgeons 1997, 184: 529-39. PMID: 9145078.Peer-Reviewed Original Research
1993
Phospholipase C: A Putative Mechanotransducer for Endothelial Cell Response to Acute Hemodynamic Changes
Brophy CM, Mills I, Rosales O, Isales C, Sumpio BE. Phospholipase C: A Putative Mechanotransducer for Endothelial Cell Response to Acute Hemodynamic Changes. Biochemical And Biophysical Research Communications 1993, 190: 576-581. PMID: 8427600, DOI: 10.1006/bbrc.1993.1087.Peer-Reviewed Original ResearchConceptsEndothelial cellsAcute hemodynamic changesPhospholipase C activationHemodynamic changesProduction of inositolAcute decreaseAcute increaseIP3 generationEndothelial cell responsesCell responsesIP3 productionPutative mechanotransducersTransient increaseSpecific signal transduction pathwaysOngoing studiesCardiac cycleC activationSignal transduction pathwaysTransduction pathways