2018
Radiotracer Imaging Allows for Noninvasive Detection and Quantification of Abnormalities in Angiosome Foot Perfusion in Diabetic Patients With Critical Limb Ischemia and Nonhealing Wounds
Alvelo JL, Papademetris X, Mena-Hurtado C, Jeon S, Sumpio BE, Sinusas AJ, Stacy MR. Radiotracer Imaging Allows for Noninvasive Detection and Quantification of Abnormalities in Angiosome Foot Perfusion in Diabetic Patients With Critical Limb Ischemia and Nonhealing Wounds. Circulation Cardiovascular Imaging 2018, 11: e006932. PMID: 29748311, PMCID: PMC5951395, DOI: 10.1161/circimaging.117.006932.Peer-Reviewed Original ResearchMeSH KeywordsAnkle Brachial IndexCase-Control StudiesCritical IllnessDiabetic FootHumansIschemiaMicrocirculationOrganophosphorus CompoundsOrganotechnetium CompoundsPerfusion ImagingPredictive Value of TestsRadiopharmaceuticalsRegional Blood FlowSingle Photon Emission Computed Tomography Computed TomographyWound HealingConceptsCritical limb ischemiaAnkle-brachial indexStandardized uptake valueSPECT/CT imagingDiabetic patientsHealthy subjectsSPECT/CTFoot perfusionUptake valueLimb ischemiaMicrovascular perfusionSkeletal muscle microvascular perfusionCT imagingDiabetic CLI patientsMuscle microvascular perfusionPeripheral artery diseaseSingle photon emissionIntraclass correlation coefficientAngiosome perfusionCLI subjectsCLI patientsArtery diseaseDiabetes mellitusCT perfusionVascular territories
2017
Management of Chronic Wounds: Diagnosis, Preparation, Treatment, and Follow-up.
Gupta S, Andersen C, Black J, de Leon J, Fife C, Lantis Ii JC, Niezgoda J, Snyder R, Sumpio B, Tettelbach W, Treadwell T, Weir D, Silverman RP. Management of Chronic Wounds: Diagnosis, Preparation, Treatment, and Follow-up. WOUNDS A Compendium Of Clinical Research And Practice 2017, 29: s19-s36. PMID: 28862980.Peer-Reviewed Original ResearchConceptsChronic wound typesChronic woundsWound typesCare settingsAccurate diagnosisCurrent evidence-based guidelinesPressure ulcers/injuriesVenous leg ulcersEvidence-based guidelinesEvidence-based criteriaTerms of prevalenceLeg ulcersPatient adherenceTreatment algorithmDiabetic footTherapy optionsWound recurrenceSurgical woundsCare plansHolistic careTherapy selectionChronic wound diagnosisAppropriate managementDiagnosisExpert panel
2016
Percutaneous endovascular aneurysm repair in morbidly obese patients
Chin JA, Skrip L, Sumpio BE, Cardella JA, Indes JE, Sarac TP, Dardik A, Chaar C. Percutaneous endovascular aneurysm repair in morbidly obese patients. Journal Of Vascular Surgery 2016, 65: 643-650.e1. PMID: 28034584, DOI: 10.1016/j.jvs.2016.06.115.Peer-Reviewed Original ResearchMeSH KeywordsAdultAneurysmCatheterization, PeripheralChi-Square DistributionDatabases, FactualEndovascular ProceduresFemaleFemoral ArteryHumansMaleMiddle AgedObesity, MorbidOperative TimePostoperative ComplicationsPuncturesRetrospective StudiesRisk FactorsTime FactorsTreatment OutcomeUnited StatesWound HealingConceptsEndovascular aneurysm repairMO patientsSuperobese patientsObese patientsAneurysm repairSurgical outcomesSevere chronic obstructive pulmonary diseaseShorter total operation timeTotal endovascular aneurysm repairChronic obstructive pulmonary diseasePercutaneous endovascular aneurysm repairSurgeons National Surgical Quality Improvement Program filesMorbidly obese patientsObstructive pulmonary diseaseSimilar baseline characteristicsPercutaneous femoral accessCurrent Procedural TerminologyPEVAR groupBaseline comorbiditiesWound complicationsBaseline characteristicsFemoral accessPulmonary diseaseTotal operation timeFemoral cutdown
2015
Venous Ulcer: Late Complication of a Traumatic Arteriovenous Fistula
Young CJ, Dardik A, Sumpio B, Indes J, Muhs B, Chaar C. Venous Ulcer: Late Complication of a Traumatic Arteriovenous Fistula. Annals Of Vascular Surgery 2015, 29: 836.e1-836.e3. PMID: 25725283, DOI: 10.1016/j.avsg.2014.11.020.Peer-Reviewed Case Reports and Technical NotesConceptsTraumatic AVFsLate complicationsArteriovenous fistula formationCongestive heart failureTraumatic arteriovenous fistulaDistal ischemiaHard signsVenous dilatationHeart failureInitial presentationOpen repairFistula formationVenous congestionArteriovenous fistulaVascular injuryCase reportAVFOperating roomComplicationsInjurySignsFistulaIschemiaUlcersPatients
2013
Fundamentals of randomized clinical trials in wound care: Reporting standards
Brölmann FE, Eskes AM, Sumpio BE, Mayer DO, Moore Z, Ågren M, Hermans M, Cutting K, Legemate DA, Vermeulen H, Ubbink DT. Fundamentals of randomized clinical trials in wound care: Reporting standards. Wound Repair And Regeneration 2013, 21: 641-647. PMID: 23937172, DOI: 10.1111/wrr.12087.Peer-Reviewed Original ResearchA Comparison of Immediate Postoperative Rigid and Soft Dressings for Below-Knee Amputations
Sumpio B, Shine SR, Mahler D, Sumpio BE. A Comparison of Immediate Postoperative Rigid and Soft Dressings for Below-Knee Amputations. Annals Of Vascular Surgery 2013, 27: 774-780. PMID: 23880455, DOI: 10.1016/j.avsg.2013.03.007.Peer-Reviewed Original ResearchConceptsRigid dressingSoft dressingsDressing groupHealing timeYale-New Haven HospitalSoft dressing groupKaplan-Meier analysisBelow knee amputationEvidence-based guidelinesQuicker healing timeNew Haven HospitalInitial castingPlastic dressingEarly ambulationPatient demographicsDiabetes mellitusKnee amputationPostoperative dressingKnee immobilizerRetrospective analysisAverage agePatientsPostsurgical dressingsRigid plasterKnee amputees
2012
Fundamentals of randomized clinical trials in wound care: Design and conduct
Eskes AM, Brölmann FE, Sumpio BE, Mayer D, Moore Z, Ågren M, Hermans M, Cutting K, Legemate DA, Ubbink DT, Vermeulen H. Fundamentals of randomized clinical trials in wound care: Design and conduct. Wound Repair And Regeneration 2012, 20: 449-455. PMID: 22642397, DOI: 10.1111/j.1524-475x.2012.00799.x.Peer-Reviewed Original ResearchConceptsRandomized clinical trialsClinical trialsAdequate allocation concealmentWound care interventionsPatient-oriented outcomesStrong scientific evidenceQuality of studiesConduct of futureOutcome assessorsWound care productsTreat analysisCare decision makingAllocation concealmentCare interventionsWound careLower riskAcute woundsStudy designEvidence baseTrialsScientific evidenceTreatment effectsRobust comparative studiesCareSources of bias
2010
Retrospective evaluation of clinical outcomes in subjects with split‐thickness skin graft: comparing V.A.C.® therapy and conventional therapy in foot and ankle reconstructive surgeries
Blume PA, Key JJ, Thakor P, Thakor S, Sumpio B. Retrospective evaluation of clinical outcomes in subjects with split‐thickness skin graft: comparing V.A.C.® therapy and conventional therapy in foot and ankle reconstructive surgeries. International Wound Journal 2010, 7: 480-487. PMID: 20825510, PMCID: PMC7951281, DOI: 10.1111/j.1742-481x.2010.00728.x.Peer-Reviewed Original ResearchConceptsAnkle reconstructive surgeryConventional therapyGraft survivalNPWT/ROCFClinical outcomesReconstructive surgerySplit-thickness skin graft survivalSplit-thickness skin graftNegative pressure wound therapyDuration of graftImproved graft survivalOverall graft takeVacuum-Assisted TherapySkin graft survivalPressure wound therapyGraft failureRetrospective reviewRetrospective studyOutpatient treatmentGraft takeSkin graftsCT groupWound therapyRetrospective evaluationLevel I
2009
The mechanisms of action of vacuum assisted closure: More to learn
Orgill DP, Manders EK, Sumpio BE, Lee RC, Attinger CE, Gurtner GC, Ehrlich HP. The mechanisms of action of vacuum assisted closure: More to learn. Surgery 2009, 146: 40-51. PMID: 19541009, DOI: 10.1016/j.surg.2009.02.002.Peer-Reviewed Original Research
2008
Role of Negative Pressure Wound Therapy in Treating Peripheral Vascular Graft Infections
Sumpio BE, Allie DE, Horvath KA, Marston WA, Meites HL, Mills JL, Orgill DP, Salazar JD, Song DH, Toursarkissian B. Role of Negative Pressure Wound Therapy in Treating Peripheral Vascular Graft Infections. Vascular 2008, 16: 194-200. PMID: 18845099, DOI: 10.2310/6670.2008.00041.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, TopicalAnti-Infective AgentsDiabetic FootFemaleGroinHumansMaleNegative-Pressure Wound TherapyOcclusive DressingsPeripheral Vascular DiseasesPractice Guidelines as TopicProsthesis-Related InfectionsSurgical FlapsSurgical Wound InfectionVascular Surgical ProceduresWound HealingConceptsNegative pressure wound therapyPressure wound therapyGroin infectionWound therapyRole of NPWTLarger subcutaneous vesselsVascular graft infectionVascular surgical proceduresDiabetic foot ulcersOpen abdominal woundsGraft infectionWound complicationsFoot ulcersSurgical closureTreatment modalitiesBody of evidenceVascular surgeryAbdominal woundsLarge blood vesselsConsensus panelSurgical proceduresSubcutaneous vesselsComplex woundsProblematic woundsClinical practice
2007
Effect of different frequencies of tensile strain on human dermal fibroblast proliferation and survival
Nishimura K, Blume P, Ohgi S, Sumpio BE. Effect of different frequencies of tensile strain on human dermal fibroblast proliferation and survival. Wound Repair And Regeneration 2007, 15: 646-656. PMID: 17971010, DOI: 10.1111/j.1524-475x.2007.00295.x.Peer-Reviewed Original ResearchConceptsMitogen-activated protein kinaseP38 mitogen-activated protein kinaseMAPK/ERK kinaseExtracellular signal-regulated kinaseDominant-negative AktHuman dermal fibroblastsSignal-regulated kinaseCell numberERK kinaseProtein kinaseTransduction pathwaysDermal fibroblastsRelevant transduction pathwaysRelevant signal pathwaysDermal fibroblast proliferationHuman dermal fibroblast proliferationCultured human dermal fibroblastsSurvival of fibroblastsSignal pathwayKinaseNecrotic fibroblastsDNA synthesisCell proliferationAktTransferase-mediated dUTP nick-end labeling stainingPredictors for the Healing of Transmetatarsal Amputations: Retrospective Study of 91 Amputations
Blume P, Salonga C, Garbalosa J, Pierre-Paul D, Key J, Gahtan V, Sumpio BE. Predictors for the Healing of Transmetatarsal Amputations: Retrospective Study of 91 Amputations. Vascular 2007, 15: 126-133. PMID: 17573017, DOI: 10.2310/6670.2007.00035.Peer-Reviewed Original Research
2006
The management of deep sternal wound infections using vacuum assisted closure™ (V.A.C.®) therapy
Fleck T, Gustafsson R, Harding K, Ingemansson R, Lirtzman MD, Meites HL, Moidl R, Price P, Ritchie A, Salazar J, Sjögren J, Song DH, Sumpio BE, Toursarkissian B, Waldenberger F, Wetzel‐Roth W. The management of deep sternal wound infections using vacuum assisted closure™ (V.A.C.®) therapy. International Wound Journal 2006, 3: 273-280. PMID: 17199763, PMCID: PMC7951489, DOI: 10.1111/j.1742-481x.2006.00273.x.Peer-Reviewed Original ResearchMeSH KeywordsHumansPostoperative CareSternumSurgical Wound InfectionTreatment OutcomeVacuumWound HealingConceptsDeep sternal wound infectionSternal wound infectionWound infectionV.A.C. therapyThorough wound irrigationPrinciples of treatmentVacuum-assisted closureTreatment of infectionsSurgical debridementClinical guidelinesEarly recognitionWound irrigationAssisted closureCurrent evidenceSurgical supervisionTherapyInfectionAdequate experienceInternational expertsTreatmentInternational groupDebridementGroupGroup discussionsClinicians
2004
The role of thrombospondin-1 in human disease1
Esemuede N, Lee T, Pierre-Paul D, Sumpio BE, Gahtan V. The role of thrombospondin-1 in human disease1. Journal Of Surgical Research 2004, 122: 135-142. PMID: 15522326, DOI: 10.1016/j.jss.2004.05.015.Peer-Reviewed Original Research
2002
Single-Stage Surgical Treatment of Noninfected Diabetic Foot Ulcers
Blume PA, Paragas LK, Sumpio BE, Attinger CE. Single-Stage Surgical Treatment of Noninfected Diabetic Foot Ulcers. Plastic & Reconstructive Surgery 2002, 109: 601-609. PMID: 11818842, DOI: 10.1097/00006534-200202000-00029.Peer-Reviewed Original ResearchConceptsSingle-stage surgical treatmentHospital staySurgical treatmentRecurrence rateSingle-stage approachPerioperative hospital stayAdditional surgical proceduresDiabetic foot woundsLevel of ambulationDiabetic foot ulcersImmediate primary closureLocal random flapsMedian total timeExpedient returnPedal ulcersAmbulatory statusPostoperative complicationsChart reviewFoot ulcersFoot woundsPathologic findingsTotal excisionRetrospective studyPrimary closureOsseous deformities
1996
The pathobiology of diabetes mellitus: implications for surgeons.
Kamal K, Powell RJ, Sumpio BE. The pathobiology of diabetes mellitus: implications for surgeons. Journal Of The American College Of Surgeons 1996, 183: 271-89. PMID: 8784324.Peer-Reviewed Original Research