2003
Immunobiologic analysis of arterial tissue in Buerger's disease
Lee T, Seo J, Sumpio BE, Kim SJ. Immunobiologic analysis of arterial tissue in Buerger's disease. European Journal Of Vascular And Endovascular Surgery 2003, 25: 451-457. PMID: 12713785, DOI: 10.1053/ejvs.2002.1869.Peer-Reviewed Original ResearchConceptsThromboangiitis obliteransT cellsVaso vasorumI-NOSVCAM-1Endothelial cellsDegree of recanalizationT lymphocyte infiltrationCD4 T cellsInflammatory cytokine detectionInterferon-gamma mRNABuerger's diseasePatent arteriesCD8 cellsImmunologic injuryLymphocyte infiltrationImmune inflammationImmune injuryLuminal obliterationEtiologic mechanismsTUNEL studiesCell activationArterial wallRT-PCRCytokine detection
1998
Induction of interleukin (IL)‐1α and β gene expression in human keratinocytes exposed to repetitive strain: Their role in strain‐induced keratinocyte proliferation and morphological change
Takei T, Kito H, Du W, Mills I, Sumpio B. Induction of interleukin (IL)‐1α and β gene expression in human keratinocytes exposed to repetitive strain: Their role in strain‐induced keratinocyte proliferation and morphological change. Journal Of Cellular Biochemistry 1998, 69: 95-103. PMID: 9548558, DOI: 10.1002/(sici)1097-4644(19980501)69:2<95::aid-jcb1>3.0.co;2-p.Peer-Reviewed Original ResearchConceptsIL-1 antibodyIL-1 alphaIL-1Keratinocyte proliferationIL-1 mRNA expressionKeratinocyte biologyIL-1 gene expressionInduction of interleukinIL-1 betaIL-1 expressionMorphological changesΒ gene expressionAutocrine regulationMRNA expressionBeta mRNAGene expressionBasal rateBasic cellular propertiesHuman keratinocytesAntibodiesKeratinocyte functionRepetitive strainNorthern blot analysisBlot analysisProliferation
1997
Cyclic strain stimulates isoform‐specific PKC activation and translocation in cultured human keratinocytes
Takei T, Han O, Ikeda M, Male P, Mills I, Sumpio B. Cyclic strain stimulates isoform‐specific PKC activation and translocation in cultured human keratinocytes. Journal Of Cellular Biochemistry 1997, 67: 327-337. PMID: 9361188, DOI: 10.1002/(sici)1097-4644(19971201)67:3<327::aid-jcb5>3.0.co;2-y.Peer-Reviewed Original ResearchEffect of strain on human keratinocytes in vitro
Takei T, Rivas‐Gotz C, Delling C, Koo J, Mills I, McCarthy T, Centrella M, Sumpio B. Effect of strain on human keratinocytes in vitro. Journal Of Cellular Physiology 1997, 173: 64-72. PMID: 9326450, DOI: 10.1002/(sici)1097-4652(199710)173:1<64::aid-jcp8>3.0.co;2-h.Peer-Reviewed Original Research
1995
Cyclic strain causes heterogeneous induction of transcription factors, AP-1, CRE binding protein and NF-kB, in endothelial cells: Species and vascular bed diversity
Du W, Mills I, Sumpio B. Cyclic strain causes heterogeneous induction of transcription factors, AP-1, CRE binding protein and NF-kB, in endothelial cells: Species and vascular bed diversity. Journal Of Biomechanics 1995, 28: 1485-1491. PMID: 8666588, DOI: 10.1016/0021-9290(95)00096-8.Peer-Reviewed Original ResearchMeSH KeywordsActivating Transcription Factor 2AnimalsAortaCattleCell DivisionCyclic AMP Response Element-Binding ProteinEndothelium, VascularEpoprostenolGene Expression RegulationGenes, Immediate-EarlyHumansNF-kappa BNuclear ProteinsPhenotypeProtein Kinase CSpecies SpecificityStress, MechanicalTime FactorsTranscription Factor AP-1Transcription FactorsUmbilical VeinsConceptsHuman umbilical vein endothelial cellsBovine aortic endothelial cellsActivator protein-1NF-kBEndothelial cellsVascular bedDifferent vascular bedsUmbilical vein endothelial cellsAortic endothelial cellsCultured endothelial cellsTranscription factor activator protein-1Vein endothelial cellsProstacyclin secretionStretch-induced activationImmediate early genesEC exposureNuclear factorTime pointsHeterogeneous inductionCAMP response elementProtein 1Biphasic mannerSignificant inductionDivergent effectsHuman aorta
1991
Effect of cyclic stretch on endothelial cells from different vascular beds.
Iba T, Maitz S, Furbert T, Rosales O, Widmann MD, Spillane B, Shin T, Sonoda T, Sumpio BE. Effect of cyclic stretch on endothelial cells from different vascular beds. Journal Of Inflammation 1991, 35: 193-8. PMID: 1777956.Peer-Reviewed Original Research