Urinary excretion of interferon, albumin, and beta 2-microglobulin during interferon treatment.
Sumpio BE, Ernstoff MS, Kirkwood JM. Urinary excretion of interferon, albumin, and beta 2-microglobulin during interferon treatment. Cancer Research 1984, 44: 3599-603. PMID: 6378373.Peer-Reviewed Original ResearchConceptsInterferon therapyUrinary excretionInterferon activityPhase I trialSerum interferon activityUrinary betaInterferon administrationI trialSignificant nephrotoxicityTubular lesionsUrinary levelsInterferon treatmentHighest dosing levelDosing levelsTherapyInterferonExcretionTreatmentLow affinityAlbuminBetaNephrotoxicityPatientsLesionsPharmacokinetics