2015
Surgical Treatment Principles for Diabetic Wounds Complicated by Osteomyelitis
Gates L, Blume P, Sumpio B. Surgical Treatment Principles for Diabetic Wounds Complicated by Osteomyelitis. 2015, 99-111. DOI: 10.1007/978-3-319-18926-0_10.Peer-Reviewed Original ResearchLower extremity amputationExtremity amputationSubsequent lower extremity amputationEradication of osteomyelitisOverall surgical treatmentSurgical reconstruction strategiesSurgical treatment principlesSoft tissue infectionsDiabetic osteomyelitisAdjuvant therapyOverall morbidityDevastating complicationRevascularization techniquesFoot ulcerationLimb preservationSurgical treatmentTissue infectionsSurgical eradicationTreatment principlesDiabetic woundsOsteomyelitisFunctioning limbDevastating mortalityTissue reconstructionAmputation
2014
Contemporary assessment of foot perfusion in patients with critical limb ischemia
Benitez E, Sumpio BJ, Chin J, Sumpio BE. Contemporary assessment of foot perfusion in patients with critical limb ischemia. Seminars In Vascular Surgery 2014, 27: 3-15. PMID: 25812754, DOI: 10.1053/j.semvascsurg.2014.12.001.Peer-Reviewed Original ResearchConceptsCritical limb ischemiaLimb ischemiaFoot perfusionLower extremity perfusionPeripheral arterial diseaseTranscutaneous oxygen monitoringRevascularization techniquesArterial diseaseFoot ulcerationLimb salvageRevascularization therapyFluorescent angiographyPatient outcomesEndovascular proceduresDisease processPatient careIschemiaDiagnostic imagingPatientsPerfusionImaging modalitiesLaser DopplerOxygen monitoringPlanning interventionsModalities
2012
Diabetic Foot Ulceration and Management
Blume P, Jain A, Sumpio B. Diabetic Foot Ulceration and Management. Contemporary Diabetes 2012, 63-91. DOI: 10.1007/978-1-62703-158-5_6.Peer-Reviewed Original ResearchFoot ulcersMajor public health issueGrowth factorDiabetic foot diseaseDiabetic foot ulcerationHospitalization of patientsGood clinical careTreatment of infectionsMoist wound carePublic health issueComplex clinical problemWidespread clinical practiceAbnormal foot structureAdjuvant therapySuperimposed infectionFoot ulcerationFrequent debridementLimb salvagePathophysiologic mechanismsChronic inflammationDiabetic footCostly complicationFoot problemsIschemic limbsClinical trials
2010
The Semmes Weinstein monofilament examination is a significant predictor of the risk of foot ulceration and amputation in patients with diabetes mellitus
Feng Y, Schlösser FJ, Sumpio BE. The Semmes Weinstein monofilament examination is a significant predictor of the risk of foot ulceration and amputation in patients with diabetes mellitus. Journal Of Vascular Surgery 2010, 53: 220-226.e5. PMID: 20692793, DOI: 10.1016/j.jvs.2010.06.100.Peer-Reviewed Original ResearchConceptsSemmes-Weinstein monofilament examinationLower extremity amputationDiabetes mellitusFoot ulcerationRelative riskMonofilament examinationDiabetic footPrognostic valueRisk of LEADiabetic peripheral neuropathyMEDLINE/PubMed databasePrognosis of patientsDiabetic foot ulcerationPublication date restrictionsEvidence-based toolsIndependent predictorsMajor complicationsPeripheral neuropathyPatient selectionExtremity amputationAbsolute riskDate restrictionsPrognostic studiesCurrent evidenceUlceration
2003
Charcot Joint Disease in Diabetes Mellitus
Lee L, Blume PA, Sumpio B. Charcot Joint Disease in Diabetes Mellitus. Annals Of Vascular Surgery 2003, 17: 571-580. PMID: 14508661, DOI: 10.1007/s10016-003-0039-5.Peer-Reviewed Original ResearchConceptsCharcot joint diseaseDiabetes mellitusJoint diseaseCharcot neuropathic arthropathyDiabetic foot ulcerationStructural foot deformitiesDevastating deformitiesNeuropathic arthropathyCharcot arthropathyDiabetic patientsFoot ulcerationClinical presentationDegenerative arthropathyPedal ulcerationFoot deformityFoot problemsTreatment modalitiesImmediate treatmentVascular surgeonsNeuropathic diseasePatientsMellitusArthropathyEarly signsStructural deformity
2002
Classification of Diabetic Foot Ulcers: Improving Communication
Frangos S, Kilaru S, Blume P, Shin J, Sumpio B. Classification of Diabetic Foot Ulcers: Improving Communication. International Journal Of Angiology 2002, 11: 158-164. DOI: 10.1007/s00547-002-0180-y.Peer-Reviewed Original ResearchDiabetic footCause of hospitalizationDiabetic foot ulcersAccepted classification systemDiabetic patientsFoot ulcerationFoot ulcersClassification systemWound specialistsCare providersHealthcare strategiesMultidisciplinary approachFootHospitalizationMorbidityUlcerationComplicationsUlcersPatientsAmputationMortalityClassification of diabetic foot ulcers: Improving communication
Frangos S, Kilaru S, Blume P, Shin J, Sumpio B. Classification of diabetic foot ulcers: Improving communication. International Journal Of Angiology 2002, 158-164. DOI: 10.1055/s-0031-1276359.Peer-Reviewed Original ResearchDiabetic footCause of hospitalizationDiabetic foot ulcersAccepted classification systemDiabetic patientsFoot ulcerationFoot ulcersClassification systemWound specialistsCare providersHealthcare strategiesMultidisciplinary approachFootHospitalizationMorbidityUlcerationComplicationsUlcersPatientsAmputationMortality
1998
Antiproliferative effect of elevated glucose in human microvascular endothelial cells
Kamal K, Du W, Mills I, Sumpio B. Antiproliferative effect of elevated glucose in human microvascular endothelial cells. Journal Of Cellular Biochemistry 1998, 71: 491-501. PMID: 9827695, DOI: 10.1002/(sici)1097-4644(19981215)71:4<491::aid-jcb4>3.0.co;2-p.Peer-Reviewed Original ResearchConceptsMicrovascular endothelial cellsElevated glucoseHMEC-1Endothelial cellsAntiproliferative effectsDiabetic microangiopathyDiabetic foot ulcerationHuman dermal microvascular endothelial cellsCyclic AMP accumulationMicrovascular endothelial cell lineDermal microvascular endothelial cellsHuman microvascular endothelial cellsImmortalized human dermal microvascular endothelial cell lineHigh D-glucoseDeleterious effectsHuman dermal microvascular endothelial cell linePrimary cultured cellsEndothelial cell lineFoot ulcerationHMEC-1 proliferationProliferative responseAMP accumulationPathological complicationsMolecular pathophysiologyRp-cAMPS