1999
Localization of Atherosclerosis: Role of Hemodynamics
Frangos S, Gahtan V, Sumpio B. Localization of Atherosclerosis: Role of Hemodynamics. JAMA Surgery 1999, 134: 1142-1149. PMID: 10522862, DOI: 10.1001/archsurg.134.10.1142.Peer-Reviewed Original ResearchConceptsEndothelial cell structureCoronary arteryAortic archRisk factorsAbdominal aortaChronic diseasesVascular endotheliumCircumferential strainRole of hemodynamicsLesionsHemodynamic forcesCyclic circumferential strainMajor branchesSusceptible sitesAtherosclerosisArteryAortaHemodynamicsAtherogenesisEndotheliumDisease
1994
Chronic Cyclic Strain Reduces Adenylate Cyclase Activity and Stimulatory G Protein Subunit Levels in Coronary Smooth Muscle Cells
Wiersbitzky M, Mills I, Sumpio B, Gewirtz H. Chronic Cyclic Strain Reduces Adenylate Cyclase Activity and Stimulatory G Protein Subunit Levels in Coronary Smooth Muscle Cells. Experimental Cell Research 1994, 210: 52-55. PMID: 8269996, DOI: 10.1006/excr.1994.1008.Peer-Reviewed Original ResearchConceptsVascular smooth muscle cellsSmooth muscle cellsAdenylate cyclase activityCoronary vascular smooth muscle cellsMuscle cellsCyclase activityChronic cyclic strainG protein subunit levelsCoronary smooth muscle cellsProtein steady-state levelsCoronary smooth muscleCultured smooth muscle cellsSteady-state levelsPorcine coronary arteriesCoronary arteryCoronary circulationBeta levelsCycles/minProtein subunit levelsSmooth muscleGi alphaIntravascular pressureEffector pathwaysUnstretched cellsSubunit levels